Abstract: The disclosure relates to RNA agents targeting LRP1 receptor modified for targeted delivery to the brain and/or the eye. The present invention provides modified double stranded ribonucleic acid (dsRNAi) agents conjugated to a peptide ligand, as well as methods of modulating the expression of a target gene in a CNS cell or tissue and/or an ocular cell or tissue and methods of treating subjects having a CNS and/or an ocular disease or disorder using such dsRNAi agents.

Abstract: A system includes a collar that is worn around a neck of the user. A stimulator is coupled to the collar such that the stimulator is positioned adjacent to an airway of the user. The sensor is coupled to the collar and configured to generate data associated with the airway of the user. The memory is coupled to the collar and storing machine-readable instructions. The control system is coupled to the collar and includes one or more processors configured to execute the machine-readable instructions to determine, based at least on an analysis of the generated data, that the user is currently experiencing an apnea event. In response to the determination, the control system causes the stimulator to provide electrical stimulation, at a first intensity level, to one or more muscles of the user that are adjacent to the airway to aid in stopping the apnea event.

Abstract: The disclosure relates to RNA agents modified for targeted delivery to the eye. The present invention provides modified double stranded ribonucleic acid (dsRNAi) agents conjugated to an integrin targeting ligand, as well as methods of modulating the expression of a target gene in an ocular cell or tissue and methods of treating subjects having an ocular disease or disorder using such dsRNAi agents.

Abstract: An electrical connector assembly quickly and easily provides mechanical and electrical connections between two flat flexible conductors, each having multiple electrically conductive traces provided thereon, in a sealed environment that resists the entry of contaminants therein. The electrical connector assembly includes an electrically conductive structure, a wire contact wedge supporting the electrically conductive structure, a connector housing supporting the wire contact wedge and the electrically conductive structure, and a front cover supported on the connector housing.

Abstract: A laundry treatment apparatus including a plurality of swivel casters. Two of the swivel casters are braked swivel casters. One of the swivel casters other than the braked swivel casters is a vertically adjustable swivel caster. The braked swivel casters restrain translational movement of the laundry treatment apparatus across a floor. The vertically adjustable swivel caster can help fix the position of the laundry treatment apparatus so as to restrain rocking and twisting of the laundry treatment apparatus.

Abstract: A system includes a collar that is worn around a neck of the user. A stimulator is coupled to the collar such that the stimulator is positioned adjacent to an airway of the user. The sensor is coupled to the collar and configured to generate data associated with the airway of the user. The memory is coupled to the collar and storing machine-readable instructions. The control system is coupled to the collar and includes one or more processors configured to execute the machine-readable instructions to determine, based at least on an analysis of the generated data, that the user is currently experiencing an apnea event. In response to the determination, the control system causes the stimulator to provide electrical stimulation, at a first intensity level, to one or more muscles of the user that are adjacent to the airway to aid in stopping the apnea event.

Abstract: A system and an apparatus capable of independently driving movers are described herein. The system and apparatus includes: a track that forms a path for movers; a plurality of movers movably mounted on the track for moving along the path; and a plurality of drive elements fixedly arranged along the track. The drive elements each have a surface that is oriented to contact a driven member of the movers. The drive elements are configured to sequentially engage the driven member of a plurality of the movers to provide controlled independent motion of the movers along the track. The drive elements may be driven by rotary motors. A method of independently driving movers is also described herein.

Abstract: A system and an apparatus capable of independently driving movers are described herein. The system and apparatus includes: a track that forms a path for movers; a plurality of movers movably mounted on the track for moving along the path; and a plurality of drive elements fixedly arranged along the track. The drive elements each have a surface that is oriented to contact a driven member of the movers. The drive elements are configured to sequentially engage the driven member of a plurality of the movers to provide controlled independent motion of the movers along the track. The drive elements may be driven by rotary motors. A method of independently driving movers is also described herein.

Abstract: A controller for use in an interactive gaming system is described. The controller comprising a player mounting means, a motion detector that provides a means for determining the motion of the controller and an audio code communication module. The audio code communication module provides a means for generating an audio code signal in response to a detected, predetermined motion of the controller. The audio code signals for the controller can be embedded within normal audio output of a gaming system and thereafter be employed to activate a multitude of features within the games. The gaming system may comprise an opponent based on an electronic game running on a computer device or a second controller worn by a second player. The gaming system may further comprise one or more power up toys that provide additional combat moves for the one or more participants.

Abstract: A system for aiding a user includes a stimulator, a sensor, a memory, and a control system. The stimulator is configured to be positioned in the user adjacent to an airway of the user. The sensor is configured to generate data associated with the airway of the user. The memory stores machine-readable instructions. The control system includes one or more processors configured to execute the machine-readable instructions to determine, based at least on an analysis of the generated data, that the user is currently experiencing an apnea event. In response to the determination that the user is currently experiencing an apnea event, the control system causes the stimulator to provide electrical stimulation, at a first intensity level, to one or more muscles of the user that are adjacent to the airway to aid in stopping the apnea event.

Abstract: A laundry treatment apparatus including a plurality of swivel casters. Two of the swivel casters are braked swivel casters. One of the swivel casters other than the braked swivel casters is a vertically adjustable swivel caster. The braked swivel casters restrain translational movement of the laundry treatment apparatus across a floor. The vertically adjustable swivel caster can help fix the position of the laundry treatment apparatus so as to restrain rocking and twisting of the laundry treatment apparatus.

Abstract: A reality viewer is disclosed. The reality viewer comprises a frame suitable for holding a portable electronic device and a viewing aperture. The reality viewer can interchange between a first viewing mode wherein the viewing aperture is closed and a second viewing mode wherein the viewing aperture is open. The first viewing mode is configured for virtual reality operation as a user only observes the screen of the electronic portable device located within the frame. By contrast, in the second viewing mode is configured for augmented reality operation as a user observes the real world through the viewing aperture which is augmented by images generated by the electronic portable device located within the frame. The reality viewer also has the advantage of being mobile; low cost; employs simple technology; produces an immersive, maximised field of view; and provides a real-world view in augmented reality mode of operation.

Abstract: A controller for use in an interactive gaming system is described. The controller comprising a player mounting means, a motion detector that provides a means for determining the motion of the controller and an audio code communication module. The audio code communication module provides a means for generating an audio code signal in response to a detected, predetermined motion of the controller. The audio code signals for the controller can be embedded within normal audio output of a gaming system and thereafter be employed to activate a multitude of features within the games. The gaming system may comprise an opponent based on an electronic game running on a computer device or a second controller worn by a second player. The gaming system may further comprise one or more power up toys that provide additional combat moves for the one or more participants.

Abstract: A system and an apparatus capable of independently driving movers are described herein. The system and apparatus includes: a track that forms a path for movers; a plurality of movers movably mounted on the track for moving along the path; and a plurality of drive elements fixedly arranged along the track. The drive elements each have a surface that is oriented to contact a driven member of the movers. The drive elements are configured to sequentially engage the driven member of a plurality of the movers to provide controlled independent motion of the movers along the track. The drive elements may be driven by rotary motors. A method of independently driving movers is also described herein.

Abstract: Aspects of the subject disclosure may include, a device having a non-conductive body with first and second ports that are electrically insulated from each other; a first antenna coupled to the first port; and a second antenna coupled to the second port. When the first and second ports are coupled to first and second transmission mediums, respectively: the first and second transmission mediums are electrically insulated from each other, a first electromagnetic wave conveying information and propagating along the first transmission medium causes the first antenna to transmit an RF signal to the second antenna, the RF signal conveys the information, the RF signal received at the second antenna causes a communication signal to be communicated via the second transmission medium, the communication signal conveys the information, and the first electromagnetic wave propagates along the first transmission medium without requiring an electrical return path. Other embodiments are disclosed.

Abstract: A controller for use in an interactive gaming system is described. The controller comprising a player mounting means, a motion detector that provides a means for determining the motion of the controller and an audio code communication module. The audio code communication module provides a means for generating an audio code signal in response to a detected, predetermined motion of the controller. The audio code signals for the controller can be embedded within normal audio output of a gaming system and thereafter be employed to activate a multitude of features within the games. The gaming system may comprise an opponent based on an electronic game running on a computer device or a second controller worn by a second player. The gaming system may further comprise one or more power up toys that provide additional combat moves for the one or more participants.

Abstract: A system and an apparatus capable of independently driving movers are described herein. The system and apparatus includes: a track that forms a path for movers; a plurality of movers movably mounted on the track for moving along the path; and a plurality of drive elements fixedly arranged along the track. The drive elements each have a surface that is oriented to contact a driven member of the movers. The drive elements are configured to sequentially engage the driven member of a plurality of the movers to provide controlled independent motion of the movers along the track. The drive elements may be driven by rotary motors. A method of independently driving movers is also described herein.

Abstract: A system and an apparatus capable of independently driving movers are described herein. The system and apparatus includes: a track that forms a path for movers; a plurality of movers movably mounted on the track for moving along the path; and a plurality of drive elements fixedly arranged along the track. The drive elements each have a surface that is oriented to contact a driven member of the movers. The drive elements are configured to sequentially engage the driven member of a plurality of the movers to provide controlled independent motion of the movers along the track. The drive elements may be driven by rotary motors. A method of independently driving movers is also described herein.

Abstract: A reality viewer is disclosed. The reality viewer comprises a frame suitable for holding a portable electronic device and a viewing aperture. The reality viewer can interchange between a first viewing mode wherein the viewing aperture is closed and a second viewing mode wherein the viewing aperture is open. The first viewing mode is configured for virtual reality operation as a user only observes the screen of the electronic portable device located within the frame. By contrast, in the second viewing mode is configured for augmented reality operation as a user observes the real world through the viewing aperture which is augmented by images generated by the electronic portable device located within the frame. The reality viewer also has the advantage of being mobile; low cost; employs simple technology; produces an immersive, maximised field of view; and provides a real-world view in augmented reality mode of operation.

Abstract: A system and an apparatus capable of independently driving movers are described herein. The system and apparatus includes: a track that forms a path for movers; a plurality of movers movably mounted on the track for moving along the path; and a plurality of drive elements fixedly arranged along the track. The drive elements each have a surface that is oriented to contact a driven member of the movers. The drive elements are configured to sequentially engage the driven member of a plurality of the movers to provide controlled independent motion of the movers along the track. The drive elements may be driven by rotary motors. A method of independently driving movers is also described herein.