Abstract: Dysregulation of TAF1 function by various mechanisms can lead to disease in the central nervous system, such as the TAF1 Intellectual Disability (ID) Syndrome which currently has no therapeutic treatments. The present invention indicates that a novel T-type calcium channel enhancer, such as SAK3, has disease-modifying effects in animal models of TAF1 editing. In addition, the present invention provides insights into the molecular mechanism by which SAK3 exerts in pharmacologic effects. Moreover, the present findings imply that the T-Type voltage-gated calcium channels are novel molecular targets to develop therapeutics to treat TAF1 ID syndrome and that SAK3 is an attractive drug candidate to treat TAF1 associated neurologic disorders.

Abstract: A computer-implemented method according to one embodiment includes identifying a creation of a container within a system, selecting a security policy for the container, based on one or more attributes, identifying a key label associated with the security policy for the container, retrieving a data encryption key, utilizing the key label, and encrypting the container, utilizing the data encryption key. This may enable a highly granular level of automatic container-level security within the system that may be transparently implemented within the system, which may streamline container security and reduce an amount of stored data and processing necessary for implementing container security, and may thereby improve the performance of the system.

Abstract: Cancer is the second most common cause of death worldwide, identification of cancer-specific DNA methylation events released by tumors into blood can be used for cost-effective, minimally invasive diagnostics and monitoring of cancer. The present invention clinically tested a set of ten DNA methylation specific qPCR amplicons, designed to detect most common human carcinoma types, in cell free DNA extracted from plasma fraction of blood samples from healthy controls and non-small cell lung cancer (NSCLC) cases. The DNA methylation biomarkers distinguish lung cancer cases from controls with high sensitivity and specificity (AUC=0.956), and furthermore, the signal from the markers depends on the tumor size and decreases after surgical resection of lung tumors. These observations indicate clinical value of these DNA methylation biomarkers for minimally invasive diagnostics and monitoring of NSCLC. It is predicted that these DNA methylation biomarkers will detect additional carcinoma types as well.

Abstract: Embodiments are directed to a computer-implemented method for determining whether a program has been modified. The method can include determining that a first instance of the program is loaded in main memory. The method can further include determining a starting memory location of the first instance of the program. A second instance of the program is loaded into main memory. The second instance of the program is loaded such that memory references in the second instance of the program are resolved as if the second instance were loaded at the starting memory location of the first instance of the program. The first instance of the program is compared with the second instance of the program.

Abstract: Embodiments are directed to a computer-implemented method for determining whether a program has been modified. The method can include determining that a first instance of the program is loaded in main memory. The method can further include determining a starting memory location of the first instance of the program. A second instance of the program is loaded into main memory. The second instance of the program is loaded such that memory references in the second instance of the program are resolved as if the second instance were loaded at the starting memory location of the first instance of the program. The first instance of the program is compared with the second instance of the program.

Abstract: A method to join three panels together for a motor vehicle includes one or more of the following: layering the three panels, the three panels including a first panel, a second panel, and a third panel, the second panel being positioned between the first panel and the third panel, the third panel having a higher electrical conductivity than the first panel and the second panel; joining the first panel and the second panel together; and joining the third panel to the first panel and the second panel.

Abstract: A computer-implemented method according to one embodiment includes identifying a first request from a user to access a container, determining whether the user has a first authorization to access the container, allowing the user to access the container, in response to determining that the user has the first authorization to access the container, identifying a second request from the user to access content within the container, where the content is encrypted, retrieving a key label associated with the container, determining whether the user has a second authorization to access the key label, retrieving a data encryption key, utilizing the key label, in response to determining that the user has the second authorization to access the key label, and allowing the user to access the content that is encrypted by performing one or more decryption actions, utilizing the data encryption key.

Abstract: A system, method, apparatus, and computer program product for a privacy ensured brokered identity federation system. The privacy ensured brokered identity federation system connects a user in a brokered identity federation environment that blinds relying parties (RP) from credential service providers (CSP), blinds CSPs from RPs, and blinds a user's identity and data from the federation middleware hubs. The system utilizes ring signatures to attest to CSPs that a valid RP of the federation is making a request. The process utilizes CSP ring signatures to assure RPs that a valid CSP of the federation has provided a response. The process utilizes per transaction encryption keys created by the RP to ensure the federation has no access to data messages. It can further ensure that only the correct RP can decrypt a CSP response.

Abstract: A method, apparatus, computer-readable medium, and/or system may comprise a user device configured to transmit, to a computing device, data indicative of a first routing network and data indicative of a second routing network. The computing device may comprise a processor and memory storing computer-executable instructions that, when executed by the processor, cause the computing device to receive, from the user device, the data indicative of the first routing network and the data indicative of the second routing network. The computing device may determine, based on the data indicative of the first routing network, a plurality of parameters for the first routing network. The computing device may determine, based on the data indicative of the second routing network, a plurality of parameters for the second routing network. The computing device may generate a secure session connection between the computing device and a server associated with the second routing network.

Abstract: A method, apparatus, computer-readable medium, and/or system may comprise a computing device comprising a processor and memory storing computer-executable instructions that, when executed by the processor, cause the computing device to receive, from a user device, data indicative of an item. The computing device may be located at a first location, and the user device may be located at a second location, where the first location is different from the second location. The computing device may identify the item based on item recognition using the data indicative of the item. The computing device may determine, based on the identified item, one or more routing networks for the user device to use for the identified item. The computing device may generate, for display via the user device, a notification indicating the one or more routing networks for the user device to use for the identified item.

Abstract: A method, apparatus, computer-readable medium, and/or system may comprise a computing device comprising a processor and memory storing computer-executable instructions that, when executed by the processor, cause the computing device to generate a first secure session connection between the computing device and a first server associated with a first routing network. The computing device may receive, from the first server and via the first secure session connection, data associated with the first routing network. The computing device may generate a second secure session connection between the computing device and a second server associated with a second routing network. The computing device may receive, from the second server and via the second secure session connection, data associated with the second routing network. The computing device may analyze the data associated with the first routing network and the data associated with the second routing network.

Abstract: A method, apparatus, computer-readable medium, and/or system may comprise a computing device comprising a processor and memory storing computer-executable instructions that, when executed by the processor, cause the computing device to generate a secure session connection between the computing device and a server associated with one or more routing networks. The computing device may receive, from the server and via the secure session connection, data associated with the one or more routing networks. The computing device may store, at a database, the data associated with the one or more routing networks. The computing device may determine whether new activity associated with a user and involving at least one of the one or more routing networks is detected. In response to determining that new activity associated with the user is detected, the computing device may transmit, to the database, a request for the stored data associated with the one or more routing networks.

Abstract: A user device is configured to transmit, to a computing device, data indicative of a first routing network and data indicative of a second routing network. The computing device determines, based on the received, a plurality of parameters for the first and second routing networks. The computing device may generate a secure session connection between the computing device and a server associated with the second routing network and receive, from the server and via the secure session connection, a modification to one or more parameters of the plurality of parameters for the second routing network. The computing device may determine priorities for the first routing network and the second routing network based at least in part on the plurality of parameters for the first routing network and the modification to the one or more parameters of the plurality of parameters for the second routing network.

Abstract: A method, apparatus, computer-readable medium, and/or system may comprise a computing device comprising a processor and memory storing computer-executable instructions that, when executed by the processor, cause the computing device to generate a first secure session connection between a computing device and a first server associated with a first routing network. The computing device may receive, from the first server and via the first secure session connection, a plurality of pieces of data associated with the first routing network. The computing device may generate a second secure session connection between the computing device and a second server associated with a second routing network. The computing device may receive, from the second server and via the second secure session connection, a plurality of pieces of data associated with the second routing network.

Abstract: A method, apparatus, computer-readable medium, and/or system may comprise a user device configured to transmit, to a computing device, data indicative of a first routing network and data indicative of a second routing network. The computing device may comprise a processor and memory storing computer-executable instructions that, when executed by the processor, cause the computing device to receive, from the user device, the data indicative of the first routing network and the data indicative of the second routing network. The computing device may determine, based on the data indicative of the first routing network, a plurality of parameters for the first routing network. The computing device may determine, based on the data indicative of the second routing network, a plurality of parameters for the second routing network. The computing device may generate a secure session connection between the computing device and a server associated with the second routing network.

Abstract: A computer-implemented method according to one embodiment includes identifying a first request from a user to access a container, determining whether the user has a first authorization to access the container, allowing the user to access the container, in response to determining that the user has the first authorization to access the container, identifying a second request from the user to access content within the container, where the content is encrypted, retrieving a key label associated with the container, determining whether the user has a second authorization to access the key label, retrieving a data encryption key, utilizing the key label, in response to determining that the user has the second authorization to access the key label, and allowing the user to access the content that is encrypted by performing one or more decryption actions, utilizing the data encryption key.

Abstract: A computer-implemented method according to one embodiment includes identifying a creation of a container within a system, selecting a security policy for the container, based on one or more attributes, identifying a key label associated with the security policy for the container, retrieving a data encryption key, utilizing the key label, and encrypting the container, utilizing the data encryption key. This may enable a highly granular level of automatic container-level security within the system that may be transparently implemented within the system, which may streamline container security and reduce an amount of stored data and processing necessary for implementing container security, and may thereby improve the performance of the system.

Abstract: Embodiments include a method, system, and computer program product for acquiring a data repository, the data repository being associated with a log configured to receive metadata. Then, a content of the log with respect to at least one manipulation of the data repository is modified by adding first metadata of the metadata. Further, signatures that identify control statements configured to govern the at least one manipulation of the data repository are collected by adding second metadata of the metadata into the log.

Abstract: Embodiments are directed to a computer-implemented method for determining whether a program has been modified. The method can include determining that a first instance of the program is loaded in main memory. The method can further include determining a starting memory location of the first instance of the program. A second instance of the program is loaded into main memory. The second instance of the program is loaded such that memory references in the second instance of the program are resolved as if the second instance were loaded at the starting memory location of the first instance of the program. The first instance of the program is compared with the second instance of the program.

Abstract: Embodiments are directed to a computer-implemented method for determining whether a program has been modified. The method can include determining that a first instance of the program is loaded in main memory. The method can further include determining a starting memory location of the first instance of the program. A second instance of the program is loaded into main memory. The second instance of the program is loaded such that memory references in the second instance of the program are resolved as if the second instance were loaded at the starting memory location of the first instance of the program. The first instance of the program is compared with the second instance of the program.