Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The system and method of the present invention are directed to providing and managing periodic subscription-based victuals preparation and delivery services to customers thereof, while enabling the customers to selectively alter and/or manage pending victuals deliveries, without having to make permanent changes to their subscription plan, and without necessarily sacrificing or decreasing the health, nutrition, and weight-management benefits thereof. In one exemplary embodiment, the inventive system and method transmit notification of pending victuals deliveries to customers with sufficient notice to enable customers to selectively modify and/or cancel all or a portion thereof. The inventive system and method further include an automated credit system for handling full and/or partial meal cancellations.

Abstract: A method and apparatus as provided for aiding in the strategy and tactical planning for emergency response teams by dividing a site into a plurality of locations and making 360° photographs of the site from each location. The site is interrogated at each location to obtain interrogation information of the site. Each of the photographs corresponding to each location and interrogation information for each location is stored on a computer-readable medium. A location of interest is selected and the photograph and interrogation information for the selected location are displayed.

Abstract: A method for determining one or more defective pixels in an area array image sensor wherein such defects can form a defective cluster and for producing a defect map which can be used in a digital camera for image correction includes capturing a digital image using the image sensor and storing such digital image in a memory; identifying a plurality of defective pixels which form a defective cluster in the digital image by processing the digital image data using a localized averaging filter; and forming a map identifying the location of the defective cluster in the digital image.

Abstract: A method for tuning and improving the performance of an optical communication system comprising al link that includes optical amplifiers and, optionally, active and/or passive optical components such as, e.g., DWDM's, WADM's, and optical cross-connects, includes preferentially shaping and, in particular, flattening, with respect to the input power spectrum, the output power spectrum from the amplifier, component or of the link. A flattened output power spectrum is obtained by modifying the gain spectrum operating on the respective input power spectrum. Feedback for such gain modification is typically provided by optimizing the optical signal to noise ratio of each channel of the respective output power spectrum. A system link, an optical amplifier, and optical components having flattened output power spectra are also described.

Abstract: A single mode optical waveguide fiber having a segmented core designed to provide a large effective area for light transmission. The large effective area reduces waveguide fiber non-linearities. The inventive waveguide is thus suited for transmission of high power signals over long distances. Embodiments of the inventive single mode waveguide including five core segments are given. The large effective area is achieved with essentially no degradation in optical or mechanical performance of the waveguide.

Abstract: A single mode optical waveguide fiber having a segmented core designed to provide a large effective area for light transmission. The large effective area reduces waveguide fiber non-linearities. The inventive waveguide is thus suited for transmission of high power signals over long distances. Embodiments of the inventive single mode waveguide including five core segments are given. The large effective area is achieved with essentially no degradation in optical or mechanical performance of the waveguide.

Abstract: The variables and parameters previously understood to affect the gain spectrum of an optical amplifier 13 were: (1) the wavelengths to be amplified; (2) the input power levels at those wavelengths; (3) the characteristics of the amplifying medium 20; (4) the insertion loss spectra of the amplifier's components, including any filter(s) used for gain flattening; (5) the pump band chosen to pump the amplifying medium 20; and (6) the total amount of pump power supplied in the chosen pump band. An additional fundamental variable has been identified which can be used to control the gain spectrum of an optical amplifier 13, namely, the center wavelength of the spectrum of the pump's output power within the chosen pump band. Methods and apparatus for using this variable for this purpose are disclosed.For example a, transmission system is disclosed having a transmitter 11 and a receiver 10 connected by an optical fiber 12.

Abstract: A single-mode optical waveguide fiber designed to limit power penalty due to four wave mixing and a method of making the waveguide is disclosed. Variations in properties, e.g., radius or refractive index, of the waveguide fiber core provide a total dispersion which varies along the length of the waveguide. The algebraic sum of products of length times total dispersion is controlled to a pre-selected value for each waveguide fiber which makes up a system link Proper choice of total dispersion variation magnitude and sub-length results in a system link wherein a signal travels only short distances in waveguide portions having total dispersion near zero. However, the variation of the total dispersion provides a system link which has a pre-selected dispersive effect on the signal over a selected wavelength range. The dispersive effect on the signal can be chosen to be essentially zero. A number of techniques for fabricating DM fiber are also disclosed.

Abstract: The present invention relates to a multi-wavelength multi-stage fiber amplifier exhibiting high power output with a flat balanced gain spectrum. The input stage exhibits a given passive loss and a flattened gain spectrum. The output stage exhibits a passive loss that is lower than the given passive loss and a gain spectrum that is less flat than the gain spectrum of the input stage. In a system utilizing erbium-based gain fibers, the input stage gain fiber can contain an amount of alumina sufficient to provide the desired gain spectrum flatness, while the output stage gain fiber has an alumina concentration sufficiently low to render that stage essentially lossless.

Abstract: A single-mode optical waveguide fiber designed to limit power penalty due to four wave mixing and a method of making the waveguide is disclosed. Variations in properties, e.g., radius or refractive index, of the waveguide fiber core provide a total dispersion which varies along the length of the waveguide. The algebraic sum of products of length times total dispersion is controlled to a pre-selected value for each waveguide fiber which makes up a system link. Proper choice of total dispersion variation magnitude and sub-length results in a system link wherein a signal travels only short distances in waveguide portions having total dispersion near zero. However, the variation of the total dispersion provides a system link which has a pre-selected dispersive effect on the signal over a selected wavelength range. The dispersive effect on the signal can be chosen to be essentially zero. A number of techniques for fabricating DM fiber are also disclosed.

Abstract: A single mode optical waveguide fiber having a segmented core designed to provide a large effective area for light transmission. The large effective area reduces waveguide fiber non-linearities. The inventive waveguide is thus suited for transmission of high power signals over long distances. Embodiments of the inventive single mode waveguide including five core segments are given. The large effective area is achieved with essentially no degradation in optical or mechanical performance of the waveguide.

Abstract: A single mode optical waveguide fiber having low, non-zero dispersion over a pre-selected wavelength range is disclosed. The refractive index profile of the core is characterized in that the core includes a plurality of distinct regions, each having an index profile, and a radius or width. By adjusting the index profile sizes and shapes of the plurality of core regions, a waveguide fiber may be made having a set of properties tailored for a high performance telecommunication system. In particular, dispersion slope can be maintained less than 0.05 ps/nm.sup.2 -km and absolute magnitude of total dispersion maintained in the range of 0.5 to 3.5 ps/nm-km over a pre-selected wavelength range. The zero dispersion wavelength is outside the pre-selected wavelength range and the cut off wavelength and mode field diameter are controlled to target values.

Abstract: The present invention is directed to the preparation of two groups of transparent glass-ceramics exhibiting high optical clarity and containing essentially only one crystal phase. The first group consists essentially, in cation percent, of______________________________________ SiO.sub.2 20-35 PbF.sub.2 19-23 AlO.sub.1.5 10-20 YF.sub.3 3-7, CdF.sub.2 19-34 ______________________________________and the second group consists essentially, in cation percent, of ______________________________________ SiO.sub.2 20-35 PbF.sub.2 15-25 AlO.sub.1.5 10-20 YF.sub.3 3-7 CdF.sub.2 21-31 ZnF.sub.2 3-7. ______________________________________These glass-ceramics may be used to fabricate optical waveguide fibers. Also when doped with certain rare earth elements, notably Pr, Er, and Dy, the glass-ceramic materials may be used to fabricate optical amplifiers and lasers.

Abstract: The present invention is directed to the preparation of two groups of transparent glass-ceramics exhibiting high optical clarity and containing essentially only one crystal phase. The first group consists essentially, in cation percent, of______________________________________ SiO.sub.2 20-35 PbF.sub.2 19-23 AlO.sub.1.5 10-20 YF.sub.3 3-7, CdF.sub.2 19-34 ______________________________________and the second group consists essentially, in cation percent, of ______________________________________ SiO.sub.2 20-35 PbF.sub.2 15-25 AlO.sub.1.5 10-20 YF.sub.3 3-7 CdF.sub.2 21-31 ZnF.sub.2 3-7.

Abstract: The present invention relates to a multi-stage fiber amplifier in which the first and stages are connected by means including a filter for attenuating the amplified spontaneous emission. The pump source consists of a pair of light sources that are connected to a coupler that splits the power equally to two output legs. All of the pump power from the second coupler output leg is supplied to the second stage. A portion of the pump power from the second coupler output leg is converted in the first stage to amplified signal and amplified spontaneous emission, and the remainder of the power from that leg is supplied to the second stage.

Abstract: This invention is directed broadly to transparent glasses exhibiting excellent transmission far into the infrared region of the electromagnetic radiation spectrum, those glasses consisting essentially, expressed in terms of mole percent, of 40-80% Ga.sub.2 S.sub.3, 0-35% RS.sub.x, wherein R is at least one network forming cation selected from the group consisting of aluminum, antimony, arsenic, germanium, and indium, 1-50% Ln.sub.2 S.sub.3, wherein Ln is at least one cation selected from the group consisting of a rare earth metal cation and yttrium, 1-45% MS.sub.x, wherein M is at least one modifying metal cation selected from the group consisting of barium, cadmium, calcium, lead, lithium, mercury, potassium, silver, sodium, strontium, thallium, and tin, and 0-10% total chloride and/or fluoride. Glass compositions consisting essentially, expressed in terms of mole percent, of 5-30% Ga.sub.2 S.sub.3, 0-10% R.sub.2 S.sub.

Abstract: This invention is directed to the production of transparent glasses exhibiting excellent transmission far into the infrared region of the electromagnetic radiation spectrum, said glasses consisting essentially, expressed in terms of mole percent on the sulfide basis, of 55-95% GeS.sub.2, 2-40% As.sub.2 S.sub.3, 0.01-20% R.sub.2 S.sub.3, wherein R is at least one trivalent network forming cation selected from the group consisting of gallium and indium, 0-10% MS.sub.x, wherein M is at least one modifying cation selected from the group consisting of aluminum, barium, cadmium, calcium, lead, lithium, mercury, potassium, silver, sodium, strontium, thallium, tin, yttrium, and a rare earth metal of the lanthanide series, 0-20% total of at least one halide selected from the group consisting of chloride and fluoride, 0-5% total selenide, and wherein the sulfur and/or selenium content can vary between 85-125% of the stoichiometric value.

Abstract: Disclosed is a fiber amplifier system including a gain fiber having a single-mode core containing dopant ions capable of producing stimulated emission of light at wavelength ?s when pumped with light of wavelength ?p. Absorbing ion filtering means is operatively associated with the gain fiber to alter the gain curve. If the absorbing ions are the same as the gain ions of the gain fiber, the system further includes means for preventing pump light from exciting the gain ions of the filtering means. The excitation prevention means may take the form of means for attenuating pump light. If the absorbing ions are different from the dopant ions of the gain fiber, such absorbing ions can be subjected to light at wavelength ?p, but they will remain unexcited. Such absorbing ions can be used to co-dope the gain fiber, or they can be incorporated into the core of a fiber that is in series with the gain fiber.

Abstract: This invention is directed broadly to transparent glasses exhibiting excellent transmission far into the infrared region of the electromagnetic radiation spectrum, those glasses consisting essentially, expressed in terms of mole percent, of 40-80% Ga.sub.2 S.sub.3, 0-35% RS.sub.x, wherein R is at least one network forming cation selected from the group consisting of aluminum, antimony, arsenic, germanium, and indium, 1-50% Ln.sub.2 S.sub.3, wherein Ln is at least one cation selected from the group consisting of a rare earth metal cation and yttrium, 1-45% MS.sub.x, wherein M is at least one modifying metal cation selected from the group consisting of barium, cadmium, calcium, lead, lithium, mercury, potassium, silver, sodium, strontium, thallium, and tin, and 0-10% total chloride and/or fluoride. Glass compositions consisting essentially, expressed in terms of mole percent, of 5-30% Ga.sub.2 S.sub.3, 0-10% R.sub.2 S.sub.