Patents by Inventor Mark A. Nitz
Mark A. Nitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20210102949Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.Type: ApplicationFiled: September 18, 2020Publication date: April 8, 2021Inventors: Mark Nitz, Landon J. Edgar, Bradly G. Wouters, David Hedley, Lisa M. Willis, Matthew A. Lumba, Hanuel Park, Ravi N. Vellanki
-
Publication number: 20200362062Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: May 5, 2020Publication date: November 19, 2020Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
-
Patent number: 10816552Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.Type: GrantFiled: January 11, 2019Date of Patent: October 27, 2020Assignees: The Governing Council of the University of Toronto, University Health NetworkInventors: Mark Nitz, Landon J. Edgar, Bradly G. Wouters, David Hedley, Lisa M. Willis, Matthew A. Lumba, Hanuel Park, Ravi N. Vellanki
-
Patent number: 10752707Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: July 9, 2019Date of Patent: August 25, 2020Assignee: FLUIDIGM CANADA INC.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
-
Patent number: 10669358Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: July 27, 2018Date of Patent: June 2, 2020Assignee: FLUIDIGM CANADA INC.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
-
Patent number: 10570114Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: GrantFiled: July 26, 2018Date of Patent: February 25, 2020Assignee: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
-
Patent number: 10544121Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: GrantFiled: July 26, 2018Date of Patent: January 28, 2020Assignee: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
-
Publication number: 20190345272Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: July 9, 2019Publication date: November 14, 2019Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
-
Publication number: 20190250165Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.Type: ApplicationFiled: January 11, 2019Publication date: August 15, 2019Inventors: Mark Nitz, Landon J. Edgar, Bradly G. Wouters, David Hedley, Lisa M. Willis, Matthew A. Lumba, Hanuel Park, Ravi N. Vellanki
-
Publication number: 20190077890Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: July 27, 2018Publication date: March 14, 2019Applicant: FLUIDIGM CANADA INC.Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
-
Patent number: 10222380Abstract: A compound of formula (I) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged 2-nitroimidazole.Type: GrantFiled: August 20, 2015Date of Patent: March 5, 2019Assignees: The Governing Council of the University of Toronto, University Health NetworkInventors: Mark Nitz, Landon J. Edgar, Bradley G. Wouters, David Hedley, Lisa M. Willis, Matthew A. Lumba, Hanuel Park, Ravi N. Vellanki
-
Publication number: 20180334445Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: ApplicationFiled: July 26, 2018Publication date: November 22, 2018Applicant: Dow AgroSciences LLCInventors: Jason S. F, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
-
Publication number: 20180334444Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: ApplicationFiled: July 26, 2018Publication date: November 22, 2018Applicant: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jooossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
-
Patent number: 10087164Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This invention was expanded to include synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: GrantFiled: May 19, 2017Date of Patent: October 2, 2018Assignee: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
-
Patent number: 10072104Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: October 5, 2015Date of Patent: September 11, 2018Assignee: Fluidigm Canada Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
-
Publication number: 20170334878Abstract: Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalky and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This invention was expanded to include synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.Type: ApplicationFiled: May 19, 2017Publication date: November 23, 2017Applicant: Dow AgroSciences LLCInventors: Jason S. Fisk, Xiaoyong Li, Mark Muehlfeld, Robert S. Bauman, Jossian Oppenheimer, Siyu Tu, Mark A. Nitz, Reetam Chakrabarti, Shawn D. Feist, James W. Ringer, Ronald B. Leng
-
Publication number: 20170269094Abstract: A compound of formula (I) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged 2-nitroimidazole.Type: ApplicationFiled: August 20, 2015Publication date: September 21, 2017Inventors: MARK NITZ, LANDON J. EDGAR, BRADLEY G. WOUTERS, DAVID HEDLEY, LISA M. WILLIS, MATTHEW A. LUMBA, HANUEL PARK, RAVI N. VELLANKI
-
Patent number: 9296838Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: March 16, 2015Date of Patent: March 29, 2016Assignee: Fluidigm Canada, Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
-
Publication number: 20160025731Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: October 5, 2015Publication date: January 28, 2016Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
-
Patent number: 9169335Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: March 16, 2015Date of Patent: October 27, 2015Assignee: Fluidigm Canada, Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou