Patents by Inventor Mark A. Osgood
Mark A. Osgood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11417507Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.Type: GrantFiled: November 30, 2020Date of Patent: August 16, 2022Inventors: Mark A Osgood, Ching Wu
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Patent number: 11024497Abstract: An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.Type: GrantFiled: March 3, 2020Date of Patent: June 1, 2021Assignee: Excellims Corp.Inventors: Ching Wu, Mark A. Osgood
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Publication number: 20210111012Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.Type: ApplicationFiled: November 30, 2020Publication date: April 15, 2021Applicant: Excellims CorporationInventors: Mark A Osgood, Ching Wu
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Patent number: 10854437Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.Type: GrantFiled: August 13, 2018Date of Patent: December 1, 2020Assignee: Excellims CorporationInventors: Mark A Osgood, Ching Wu
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Publication number: 20200203140Abstract: An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.Type: ApplicationFiled: March 3, 2020Publication date: June 25, 2020Applicant: Excellims CorporationInventors: Ching Wu, Mark A. Osgood
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Publication number: 20190285583Abstract: The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. In addition, automation of the direct spray needle can be achieved by setting up array of the spray needles that are loaded in a manner that rotates and/or moves to the next spray needle in the ESI source region.Type: ApplicationFiled: June 3, 2019Publication date: September 19, 2019Applicant: Excellims CorporationInventors: Ching Wu, Mark A. Osgood, Eugenie Hainsworth, Clinton Alawn Krueger, Taeman Kim
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Publication number: 20190259595Abstract: An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.Type: ApplicationFiled: April 28, 2019Publication date: August 22, 2019Applicant: Excellims CorporationInventors: Ching Wu, Mark A. Osgood
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Patent number: 10309928Abstract: The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.Type: GrantFiled: September 24, 2017Date of Patent: June 4, 2019Assignee: Excellims CorporationInventors: Ching Wu, Mark A. Osgood, Eugenie Hainsworth, Clinton Alawn Krueger, Taeman Kim
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Patent number: 10276358Abstract: An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.Type: GrantFiled: July 31, 2017Date of Patent: April 30, 2019Assignee: Excellims CorporationInventors: Ching Wu, Mark A Osgood
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Publication number: 20190006160Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.Type: ApplicationFiled: August 13, 2018Publication date: January 3, 2019Applicant: Excellims CorporationInventors: Mark A Osgood, Ching Wu
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Patent number: 10049865Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.Type: GrantFiled: May 4, 2015Date of Patent: August 14, 2018Assignee: Excellims CorporationInventors: Mark A Osgood, Ching Wu
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Publication number: 20180067078Abstract: The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.Type: ApplicationFiled: September 24, 2017Publication date: March 8, 2018Applicant: Excellims CorporationInventors: Ching Wu, Mark A. Osgood, Eugenie Hainsworth, Clinton Alawn Krueger, Taeman Kim
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Patent number: 9859105Abstract: A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.Type: GrantFiled: June 17, 2015Date of Patent: January 2, 2018Assignee: Excellims CorporationInventors: Adam Michael Graichen, Robert H Jackson, Mark A Osgood, Ching Wu, Jianglin Wu
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Publication number: 20170365454Abstract: An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.Type: ApplicationFiled: July 31, 2017Publication date: December 21, 2017Applicant: Excellims CorporationInventors: Ching Wu, Mark A. Osgood
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Patent number: 9734998Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.Type: GrantFiled: January 11, 2016Date of Patent: August 15, 2017Assignee: Excellims CorporationInventors: Ching Wu, Mark A Osgood
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Patent number: 9719963Abstract: An ion mobility spectrometry method wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. Ion mobility spectrometer operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.Type: GrantFiled: November 10, 2014Date of Patent: August 1, 2017Assignee: Excellims CorporationInventors: Ching Wu, Clinton Alawn Krueger, Anthony Joseph Midey, Mark A Osgood
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Publication number: 20160196964Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.Type: ApplicationFiled: January 11, 2016Publication date: July 7, 2016Applicant: Excellims CorporationInventors: Ching Wu, Mark A. Osgood
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Patent number: 9236234Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.Type: GrantFiled: March 14, 2014Date of Patent: January 12, 2016Assignee: Excellims CorporationInventors: Ching Wu, Mark A Osgood
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Publication number: 20160005581Abstract: A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.Type: ApplicationFiled: June 17, 2015Publication date: January 7, 2016Inventors: Adam Michael Graichen, Robert H. Jackson, Mark A. Osgood, Ching Wu, Jianglin Wu
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Patent number: 9177770Abstract: The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.Type: GrantFiled: April 19, 2010Date of Patent: November 3, 2015Assignee: Excellims CorporationInventors: Mark A. Osgood, Ching Wu