Patents by Inventor Mark A. Perreault

Mark A. Perreault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11524262
    Abstract: The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: December 13, 2022
    Assignee: REPLIGEN CORPORATION
    Inventor: Mark A. Perreault
  • Patent number: 11511232
    Abstract: Tangential flow filtration systems utilizing flexible bags for permeate collection are provided.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: November 29, 2022
    Assignee: REPLIGEN CORPORATION
    Inventor: Mark A. Perreault
  • Publication number: 20220026160
    Abstract: A dual path heat exchanger integrated as a single unit able to process fluid stream through a continuous, single-use high temperature short time process. The heat exchanger contains both a heating section and a cooling section in the same unit. In one embodiment, the heating and cooling sections (which may be formed separately for other uses) are formed as a plate and frame structure with a thermally conductive thin film or foil forming the physical barrier between the process stream flow path and the thermal medium (heating or cooling) flow path. The film/foil renders the heat exchanger suitable for single-use and/or to be disposable. A manifold, which also may be formed as a single unit, may be used to transfer fluid flow between the sections of the heat exchanger, and/or to transfer fluid into and out of the system formed by the heat exchanger and manifold.
    Type: Application
    Filed: July 13, 2021
    Publication date: January 27, 2022
    Applicant: Repligen Corporation
    Inventor: Mark A. Perreault
  • Publication number: 20210197125
    Abstract: Tangential flow filtration systems utilizing flexible bags for permeate collection are provided.
    Type: Application
    Filed: November 24, 2020
    Publication date: July 1, 2021
    Applicant: REPLIGEN CORPORATION
    Inventor: Mark A. PERREAULT
  • Publication number: 20210039045
    Abstract: The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.
    Type: Application
    Filed: July 28, 2020
    Publication date: February 11, 2021
    Applicant: REPLIGEN CORPORATION
    Inventor: Mark A. Perreault
  • Publication number: 20200171439
    Abstract: Cassettes for tangential flow filtration (TFF) are disclosed which reduce assembly and disassembly required for aseptic filtration. Packaging systems and methods for the TFF cassettes are also disclosed.
    Type: Application
    Filed: November 27, 2019
    Publication date: June 4, 2020
    Applicant: REPLIGEN CORPORATION
    Inventors: Mark A. Perreault, John F. Connors, JR., Paul C. Lowell
  • Publication number: 20100056757
    Abstract: Processes and apparati are provided for separating molecules of interest from a mixture by depth filtration (DF). The DF of the invention is useful in the clarification and processing of various feedstreams for the removal of a molecule of interest. According to a preferred embodiment, a transgenic milk feedstream is stabilized and particulate matter such as fat, casein miscelles and bacteria are removed. An aseptic filtration step was also developed to remove any bacteria remaining in a clarified transgenic milk feedstream.
    Type: Application
    Filed: April 3, 2009
    Publication date: March 4, 2010
    Applicant: GTC Biotherapeutics, Inc,
    Inventor: Mark A. Perreault
  • Patent number: 7531632
    Abstract: Processes and apparati are provided for separating molecules of interest from a mixture by depth filtration (DF). The DF of the invention is useful in the clarification and processing of various feedstreams for the removal of a molecule of interest. According to a preferred embodiment, a transgenic milk feedstream is stabilized and particulate matter such as fat, casein miscelles and bacteria are removed. An aseptic filtration step was also developed to remove any bacteria remaining in a clarified transgenic milk feedstream.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: May 12, 2009
    Assignee: GTC Biotherapeutics, Inc.
    Inventor: Mark A. Perreault