Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: An apposition device having a first elongate element movably coupled with a second elongate element. The second elongate element is deployable distal to the structures to be apposed, in a position transverse to the first elongate element. The first elongate element may be pulled to pull the second elongate element to move the structures into apposition. A third element may be positioned proximal to the structures to hold the structures in apposition. The third element may be a ratcheting element fixable in place with respect to the first elongate element. The apposition device may be deployed with a fine gauge needle. The second elongate element may be deployed from a side port in the needle facilitating deployment, and/or movement of the second elongate element with respect to the first elongate element and into a deployment configuration. Such arrangement may allow control of the first elongate element independent of the needle.

Abstract: Systems and methods for rendering spatial audio in accordance with embodiments of the invention are illustrated. One embodiment includes a spatial audio system, including a primary network connected speaker, including a plurality of sets of drivers, where each set of drivers is oriented in a different direction, a processor system, memory containing an audio player application, wherein the audio player application configures the processor system to obtain an audio source stream from an audio source via the network interface, spatially encode the audio source, decode the spatially encoded audio source to obtain driver inputs for the individual drivers in the plurality of sets of drivers, where the driver inputs cause the drivers to generate directional audio.

Abstract: An apparatus and method of rendering audio. A binaural signal is split on an amplitude weighting basis into a front binaural signal and a rear binaural signal, based on perceived position information of the audio. In this manner, the front-back differentiation of the binaural signal is improved.

Abstract: A cart for medical equipment includes a base having one or more wheels, a column supported by the base, and a platform supported on the column and opposite the base. The platform is configured to mount a piece of medical equipment to the cart. The cart also includes an adapter plate securable to the piece of medical equipment and configured to releasably couple to the platform. The adapter plate includes a locking assembly having one or more handles that upon actuation releases the adapter plate from the platform.

Abstract: The present invention provides antibodies or antigen-binding fragment thereof that bind and neutralize TREM1 for use in the treatment of a motor neuron degenerative disorders, in particular amyotrophic lateral sclerosis.

Abstract: A method and system for authoring a three-dimensional (3D) presentation can involve dividing a scene into a grid of equals-sized segments or non-equally sized segments, wherein one or more 360-degree cameras record the scene from a center of each segment, and a size of the each segment is proportional to a complexity of an environment captured in the scene. One or more objects can be created within the scene for a user interaction with a 3D presentation of the scene in the context of a video stream. A logical center of the object(s) can be used as a center point for recording a 360-degree video by the one or more 360-degree cameras for use as a low fidelity background video when the user interacts with the 3D presentation of the scene. The 3D presentation can be based on a 3D model.

Abstract: Systems and methods for treating a stricture, for example along the biliary and/or pancreatic tract, are disclosed. An example system may include a handle having a base having a distal end region and a proximal end region. A length adjustment member may be coupled to the handle. A length actuator may be coupled to the distal end region of the handle. A catheter shaft may be coupled to the handle. A steering mechanism may be coupled to the handle. The steering mechanism may include an elongate steering member having a first end region coupled to the handle, a first body region extending along the catheter shaft, a loop region extending about the catheter shaft, a second body region extending along the catheter shaft, and a second end region coupled to the handle.

Abstract: Aspects of the disclosure relate to processing systems using improved model-based techniques for performing virtual device simulation. A computing platform may receive commands directing the launch of a visual model corresponding to a device identifier. The computing platform may send commands directing a database to provide a state machine model corresponding to the visual model. The computing platform may receive the state machine model and subsequently an indication of a virtual interaction with the visual model. Based on the indication, the computing platform may cause a state change of the visual model and may send, to the client device, state change information corresponding to the visual model. The computing platform may receive information verifying simulated operation parameters, and based on the information the computing platform may cause an implementation update to a device, corresponding to the visual model, based on the simulated operation parameters.

Abstract: An elongate medical device is adapted to provide adjustable flexibility. The elongate medical device includes an inner coil having one or more inner coil filars extending in a first direction, and an outer coil having one or more outer filars extending in a second direction. A hypotube extends proximally from the inner coil and the outer coil. A cable extends through the inner coil and through the hypotube, where a distal end of the cable, a distal end of the inner coil and a distal end of the outer coil are all secured together at a distal end of the elongate medical device, such that applying a tensile force to the cable, relative to the hypotube, causes the inner coil and outer coil in combination to increase in stiffness.

Abstract: An air sampling device and method of sampling air. The device has a housing body and a retaining assembly for a sampling device. A plenum has a top end coupled to the housing body about an opening such that the plenum is in flow communication with the opening and receives air flow generally from the top end to the bottom end generally along the longitudinal length thereof. A flow connection is coupled to the bottom end of the plenum. A mass flow meter has an input coupled to the flow connection and is in flow communication with the plenum via the flow connection. A blower is configured to draw air past the sampling device, through the opening, and through the plenum, such that a measuring portion of the air flows through the flow connection and through the mass flow meter, which measured the flow rate of the measuring portion.

Abstract: The embodiments disclose a method including providing an aerial drone coupled wirelessly to a social distancing application on a user digital device, wherein the drone is coupled to solar cell panels for recharging its batteries, providing a strobe light coupled to the drone for signaling an S.O.S.

Abstract: Devices, systems, and methods are described related to providing nonlinear lithographic seams, such as rectilinear lithographic seams, between adjacent fields of an integrated circuit die. Such nonlinear lithographic seams include lithographic enabling structures formed in co-planar layers with respect to functional structures in functional units of the fields of the integrated circuit die. Providing nonlinear lithographic seams improves layout efficiency of the functional units of the integrated circuit die.

Abstract: Reticles, line feature patterns, and methods are described related to improving overlay margins in reticle stitching applications. A first reticle to expose a first field includes a first portion of a line feature. The first portion has a pattern inclusive of one or more pattern features. The first reticle or a second reticle to expose a second field adjacent the first filed includes a second portion of the line feature. The second portion has an inverse pattern relative to the first pattern such that, when the first and inverse patterns are overlaid, a continuous merged region is formed.

Abstract: The present disclosure generally relates to the connection, operation, automation, and autonomation of disparate computing systems, networks, and databases. The present disclosure further relates to a method for operating a plurality of legacy systems, comprising: receiving a user input string from a user; parsing the user input string into a plurality of terms; generating, for each of the plurality of legacy systems, based on the user input string, one or more legacy input strings, each of the one or more legacy input strings being executable by each of the plurality of legacy systems and comprising a syntactical arrangement of one or more of the plurality of terms; and instructing the plurality of legacy systems to execute the one or more legacy input strings.

Abstract: An air sampling device and method of sampling air. The device has a housing body and a retaining assembly for a sampling device. A plenum has a top end coupled to the housing body about an opening such that the plenum is in flow communication with the opening and receives air flow generally from the top end to the bottom end generally along the longitudinal length thereof. A flow connection is coupled to the bottom end of the plenum. A mass flow meter has an input coupled to the flow connection and is in flow communication with the plenum via the flow connection. A blower is configured to draw air past the sampling device, through the opening, and through the plenum, such that a measuring portion of the air flows through the flow connection and through the mass flow meter, which measured the flow rate of the measuring portion.

Abstract: A system is configured to move a group of containers including at least five containers simultaneously between a vehicle and a platform. The system includes a container support frame configured to support the group of containers, at least one hoist, and a conveyor. The at least one hoist is configured to raise and lower the container support frame and the containers when the containers are secured to the container support frame. The conveyor is configured to move the container support frame and the containers between the vehicle and the platform.

Abstract: A system is configured to move a group of containers including at least five containers simultaneously between a vehicle and a platform. The system includes a container support frame configured to support the group of containers, at least one hoist, and a conveyor. The at least one hoist is configured to raise and lower the container support frame and the containers when the containers are secured to the container support frame. The conveyor is configured to move the container support frame and the containers between the vehicle and the platform.