Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: There is provided a new and improved synthetic route for the synthesis of the compound 1-{2-[(1R)-1-aminoethyl]-4-chlorobenzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (Formula (I)) that is readily scalable for commercial production. Also provided are important intermediate compounds that are formed in the new and improved synthetic route for the synthesis of the compound of formula (I).

Abstract: A modular high speed, high density electrical connector configurable for use in multiple configurations, including a direct attach orthogonal configuration. The connector is assembled with modules that include shielded pairs of signal conductors with mating ends that are rotated approximately 45 degrees with respect to intermediate portions of the signal conductors. The connector may have a mating interface with receptacles in one connector and pins in the mating connector. The pins may be small diameter and may be implemented with superelastic wires so as to resist damage despite having very small effective diameter. A compact mating interface resulting from small diameter mating contact portions may enable other portions of the connector, including the shielding surrounding the signal conductors to be smaller, which may raise the resonant frequency of the connector and extend its bandwidth.

Abstract: Disclosed herein are low dielectric constant (low-k) two-dimensional covalent organic framework materials that have a dielectric constant k less than 2.4, optionally less than 1.9, and are comprised of regularly porous, covalently linked, layer structures.

Abstract: Warp sharding techniques to switch execution between divergent shards on instructions that trigger a long stall, thereby interleaving execution between diverged threads within a warp instead of across warps. The technique may be applied to mitigate pipeline stalls in applications with low warp occupancy and high divergence. Warp data cache locality may also be improved by concentrating memory accesses within a warp rather than spreading them across warps.

Abstract: The present document relates to methods and apparatus for rendering input audio for playback in a playback environment. The input audio includes at least one audio object and associated metadata, and the associated metadata indicates at least a location of the audio object. A method for rendering input audio including divergence metadata for playback in a playback environment comprises creating two additional audio objects associated with the audio object such that respective locations of the two additional audio objects are evenly spaced from the location of the audio object, on opposite sides of the location of the audio object when seen from an intended listener's position in the playback environment, determining respective weight factors for application to the audio object and the two additional audio objects, and rendering the audio object and the two additional audio objects to one or more speaker feeds in accordance with the determined weight factors.

Abstract: A door access device for a semi-trailer includes: a lock device to control access to the semi-trailer and a controller for the lock device. The lock device includes a door lock at a door of the semi-trailer, the lock device to be electrically actuated to lock and unlock the door. The controller programmed to: determine that a semi-tractor has established an electrical connection with the semi-trailer; determine whether the semi-tractor is authorized to connect to the semi-trailer; and, in response to a determination that the semi-trailer is authorized to connect to the semi-trailer, actuate the lock device to unlock the door.

Abstract: A method for controlling a dual fuel engine system includes estimating a total indicated engine load, where the total indicated engine load is based on a sum of a measured engine power and a power loss estimate. The method further includes determining a total fueling amount based on an engine speed and the total indicated engine load, where the total fueling amount includes a gas fueling amount and a diesel fueling amount. The method also includes controlling the dual fuel engine system using the total fueling amount.

Abstract: A coupling access device for a semi-trailer includes: a cover mechanism to cover an air hose coupling for pneumatic brakes of the semi-trailer, the cover mechanism to restrict access to the air hose coupling when in a closed position, and the cover mechanism to provide access to the air hose coupling when in an open position; a lock device to engage the cover mechanism in the closed position; and a controller to actuate the lock device to allow the cover mechanism to transition from the closed position to the open position.

Abstract: A method for controlling a dual fuel engine system includes determining a friction power loss amount of an internal combustion engine of the dual fuel engine system, where the friction power loss amount is based on an engine speed of the internal combustion engine and a friction torque estimate. The method also includes determining an accessory power loss amount of a power of the internal combustion engine, where the accessory power loss amount is based on the engine speed and an accessory torque estimate. The method further includes estimating a net engine power amount based on the accessory power loss amount and a brake power amount of the internal combustion engine, estimating an indicated diesel power, and estimating, based on the estimated net engine power, a first indicated engine power and a first gas power.

Abstract: Matrix particles containing one or more matrix materials and one or more hydrophobic active agents, agglomerated particles made therefrom, fibrous structures containing such matrix particles and/or agglomerated particles, and processes for making same are provided.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A wheel track monitoring system for an irrigation system monitors the condition of a wheel track and alerts an operator and/or automatically takes corrective action when a wheel track develops ruts or other conditions that may adversely affect operation of the irrigation system. The wheel track monitoring system includes a wheel track condition sensor, a location sensor, and a processing system. The processing system receives and stores wheel track condition data and location data from the sensors as the irrigation system travels across a field and creates a log of wheel track condition data for multiple locations in the field. The processing system also analyzes the wheel track condition data to determine if the condition of the wheel track is unacceptable at any locations in the irrigated field and generates a corrective action signal if the condition is unacceptable.

Abstract: Disclosed herein are ultrasound probe assemblies that include the probe, a sheath, and an accessory implement that may be selectively attached to and detached form the probe. The implement includes an attachment surface for attaching accessories thereto. The attachment surface includes a defined angle with respect to the head of the probe so that accessories attached thereto are disposed in a defined alignment with the probe. The implement includes a circumferential wall defining a cavity configure to receive the probe head therein. The cavity includes a bottom opening to expose a patient coupling surface of the probe. The assembly may include an ultrasound gel disposed within the opening. The sheath may include a stretchable band to secure the sheath to the probe. The sheath defines a sterile barrier and may be attached to the implement.

Abstract: The present disclosure relates to nanobodies, such as defined by SEQ ID NOS: 1-54, which may be encoded by SEQ ID NOS: 55-110, and which are capable of specifically binding glycoprotein VI (GPVI), as well as uses thereof, which include therapeutic and/or imaging uses.

Abstract: Quorum-based access control management may be implemented. Quorum controls may be created for determining whether to perform or deny access control operations to perform privileged tasks. When an access control operation is received, approval of the operation may be requested from members for the quorum control. If a policy for the quorum control is satisfied by approval responses, then approval to perform the access control operation may be provided.

Abstract: Methods are described for selecting or producing a cereal plant comprising a functional restorer gene for wheat G-type cytoplasmic male sterility and nucleic acids and/or polypeptides for use therein.