Abstract: Microwave catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a microwave transmission element to a renal artery via an intravascular path. Renal neuromodulation may be achieved via dielectric heating in the presence of microwave irradiation that modulates neural fibers that contribute to renal function or alters vascular structures that feed or perfuse the neural fibers.

Abstract: A method and apparatus for classifying possibly vulnerable plaques from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as vulnerable or stable.

Abstract: A method and apparatus for classifying possibly malignant lesions from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as malignant or benign. The malignant lesions are further classified to separate TN lesions from non-TN lesions.

Abstract: This invention relates to computer-assisted diagnostics and classification of prostate cancer. Specifically, the invention relates to segmentation of the prostate boundary on MRI images, cancer detection using multimodal multi-protocol MR data; and their integration for a computer-aided diagnosis and classification system for prostate cancer.

Abstract: This invention relates to supervised or unsupervised classification of biological datasets. Specifically, the invention relates to the use of Graph Embedding as a method of reducing dimensionality thereby improving supervised classification of classes, both conventional and new ones.

Abstract: A method and apparatus for classifying possibly malignant lesions from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as malignant or benign. The malignant lesions are further classified to separate TN lesions from non-TN lesions.

Abstract: This invention relates to computer-assisted diagnostics and classification of prostate cancer. Specifically, the invention relates to segmentation of the prostate boundary on MRI images, cancer detection using multimodal multi-protocol MR data; and their integration for a computer-aided diagnosis and classification system for prostate cancer.

Abstract: A method for classifying a possible cancer from a magnetic resonance spectrographic (MRS) dataset includes extracting at least one feature from the MRS dataset as being identified with the possible cancer and embedding the extracted feature into a low dimensional space to form an embedded space. The method then clusters the embedded space into clusters representing a plurality of predetermined classes and spectrally decomposing the clusters to identify substantially significant independent metabolic signatures. The method then classifies the possible cancer as belong to one of at least two cancer classes based on the identified independent metabolic signatures.

Abstract: Obtaining test data for a device under test includes obtaining a first part of the test data by testing the device at first points of a range of parameters using progressive sampling, and obtaining a second part of the test data by testing the device at second points of the range of parameters using adaptive sampling.

Abstract: This invention relates to supervised or unsupervised classification of biological datasets. Specifically, the invention relates to the use of Graph Embedding as a method of reducing dimensionality thereby improving supervised classification of classes, both conventional and new ones.

Abstract: Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.

Abstract: A device that provides a gateway between a public switching telephone network and a gateway device comprises a controller interface including telephony circuitry, power circuitry, and a master cellular phone circuit. The controller is connected to at least one public switching network. The controller interface further includes a plurality of cartridge slots connected to the telephony circuitry and the master cellular phone circuitry, wherein the telephony circuitry links the master cellular phone circuitry to the public switching telephone network. The device further includes a plurality of transceiver cartridges removeably connected to the cartridge slots of the controller interface. The transceiver cartridges are operably configured to wirelessly link the master cellular phone circuitry to the cellular networks. Additionally, the controller interface circuitry is operably configured to switch between land line telephone network and the plurality of cellular networks based on preset conditions.

Abstract: Obtaining test data for a device under test includes obtaining a first part of the test data by testing the device at first points of a range of parameters using progressive sampling, and obtaining a second part of the test data by testing the device at second points of the range of parameters using adaptive sampling.

Abstract: The invention relates to a protective collar device for an animal recovering from a wound or other insult, which prevents the animal from biting, licking, nibbling, and chewing the site of an injury, wound, sutures, bandages, and the like. The protective collar of the invention has a shield fastened at the throat to a traditional collar by longitudinal straps, or by a trough-shaped material.

Abstract: Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.

Abstract: The present invention relates to novel methods for direct visualization of the distribution of therapeutic agents, such as acetic acid, in the tissue of an animal, utilizing chemical shift magnetic resonance imaging (MRI). Said methods are particularly useful for percutaneous chemical ablation procedures to provide an optimal dosage of chemical ablation agent such as acetic acid to target tissues such as tumors, and for limiting damage to surrounding tissues.

Abstract: A base headboard for supporting the back of an injured person's head has an elongated slot with teeth racks disposed on either side of the injured person's head. The headboard also comprises straps for attaching to a spine board. Two side head blocks are removably attached to the headboard using plunger-type locks that engage an elongated slot on each side of a center portion of the headboard. Each lock is engaged to a slot of the headboard through a separate elongated slot in the corresponding head block. Advantageously, a head block may be adjusted by moving the engagement of the lock along each independent slot in the headboard and head block, respectively. In addition, a head block may be rotated around its lock.

Abstract: A resuscitation device for providing a barrier between a rescuer and a patient requiring mouth-to-mouth resuscitation. This resuscitation device includes an inflatable portion which when inflated extends in the breathing direction between the rescuer and the patient so as to be placed around at least one breathing organ of the victim. An inflation member receives airflow from the rescuer to inflate the inflatable portion. In this resuscitation device, a valve assembly permits airflow from the rescuer to the patient and diverts the exhalation and body fluids of the patient from reaching the rescuer. An additional barrier member can also be provided for shielding the rescuer from the patient.

Abstract: A base headboard for supporting the back of an injured person's head has an elongated slot with teeth racks disposed on either side of the injured person's head. The headboard also comprises straps for attaching to a spine board. Two side head blocks are removably attached to the headboard using plunger-type locks that engage an elongated slot on each side of a center portion of the headboard. Each lock is engaged to a slot of the headboard through a separate elongated slot in the corresponding head block. Advantageously, a head block may be adjusted by moving the engagement of the lock along each independent slot in the headboard and head block, respectively. In addition, a head block may be rotated around its lock.