Patents by Inventor Mark A. Rubin

Mark A. Rubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200234307
    Abstract: The present disclosure relates to systems, methods, and computer readable media for detecting periodic sequences of events. A computer-implemented method may include collecting processing times and values associated with each of a plurality of events. The method may also include assigning each of the plurality of events to at least one of a plurality of time phases, the plurality of time phases forming a period characteristic of the plurality of events. The method may also include grouping the events in each of the plurality of time phases into one or more clusters, based on the respective values associated with the events. The method may also include determining a periodic sequence of events based on the one or more clusters. The method may further include recording the periodic sequence of events in a database of periodic sequences.
    Type: Application
    Filed: March 18, 2020
    Publication date: July 23, 2020
    Applicant: FIS Financial Compliance Solutions, LLC
    Inventors: Mark A. Rubin, Stanley Tam, Minghai Li
  • Patent number: 10443102
    Abstract: The invention relates generally to new prostate cancer markers, and particularly to a class of cancer marked by the presence of missense mutations in SPOP, an E3 ubiquitin ligase component. The invention provides methods and materials for detecting and diagnosing prostate cancer by detecting these mutations and may be useful in predicting disease progression and response to therapy.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: October 15, 2019
    Assignee: Cornell University
    Inventors: Mark A. Rubin, Christopher Barbieri
  • Patent number: 10294476
    Abstract: This invention relates to diagnosis and prognosis of prostate cancer, as well as therapeutic treatment of prostate cancer. More specifically, the invention provides diagnostic and prognostic methods based on detecting nuclear enriched abundant transcript 1 (NEAT1) levels in a sample. Further provided are methods for treating prostate cancer based on targeting NEAT1 via interfering RNA.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: May 21, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Dimple Chakravarty, Mark A. Rubin
  • Publication number: 20190114640
    Abstract: The present disclosure relates to systems, methods, and computer readable media for detecting periodic sequences of events. A computer-implemented method may include collecting processing times and values associated with each of a plurality of events. The method may also include assigning each of the plurality of events to at least one of a plurality of time phases, the plurality of time phases forming a period characteristic of the plurality of events. The method may also include grouping the events in each of the plurality of time phases into one or more clusters, based on the respective values associated with the events. The method may also include determining a periodic sequence of events based on the one or more clusters. The method may further include recording the periodic sequence of events in a database of periodic sequences.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 18, 2019
    Applicant: FIS Financial Compliance Solutions, LLC
    Inventors: MARK A. RUBIN, Stanley Tam, Minghai Li
  • Patent number: 10190173
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: January 29, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 9745635
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: August 29, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 9678077
    Abstract: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: June 13, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Juan Miguel Mosquera, Kyung Park, Ya-Lin Chiu, Francesca Demichelis
  • Patent number: 9568483
    Abstract: Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN define a distinct subgroup of prostate cancer that is predisposed to the development of lethal NEPC, who will benefit from early intervention.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: February 14, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Himisha Beltran
  • Publication number: 20170037408
    Abstract: This invention relates to diagnosis and prognosis of prostate cancer, as well as therapeutic treatment of prostate cancer. More specifically, the invention provides diagnostic and prognostic methods based on detecting nuclear enriched abundant transcript 1 (NEAT1) levels in a sample. Further provided are methods for treating prostate cancer based on targeting NEAT1 via interfering RNA.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 9, 2017
    Applicant: CORNELL UNIVERSITY
    Inventors: Dimple CHAKRAVARTY, Mark A. RUBIN
  • Publication number: 20160319369
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: May 9, 2016
    Publication date: November 3, 2016
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 9458213
    Abstract: RNA transcripts representing a fusion of a human SLC45A3 nucleic acid and a human ELK4 nucleic acid that are associated with prostate cancer are described. Compositions and methods useful for detection of fusion transcripts of human SLC45A3 and ELK4 genetic sequences associated with cancer and useful for cancer therapy are provided.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: October 4, 2016
    Assignee: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Dorothee Pflueger, David S. Rickman
  • Publication number: 20160097104
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Application
    Filed: September 24, 2015
    Publication date: April 7, 2016
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 9284609
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: March 15, 2016
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 9090899
    Abstract: An in depth analysis of prostate cancer prostatectomy samples which over-express the ERG oncogene led to the discovery of a novel gene translocation in prostate cancer, between the NDRG1 gene (N-myc downstream regulated gene 1) on chromosome 8 and the ERG oncogene on chromosome 21, leading to the expression of a chimeric NDRG1-ERG protein. Methods and compositions useful for diagnosing and treating prostate cancer characterized by NDRG1-ERG fusion are described.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: July 28, 2015
    Assignee: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Dorothee Pflueger, David S. Rickman
  • Publication number: 20150132767
    Abstract: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 14, 2015
    Applicant: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Juan Miguel Mosquera, Kyung Park, Ya-Lin Chiu, Francesca Demichelis
  • Publication number: 20150104440
    Abstract: The current disclosure reveals a complex regulatory pattern between miR-31 and AR, indicating that miR-31 plays a key role in prostate cancer development and progression. Another aspect of the current disclosure shows that miR-31 directly targets and destabilizes AR mRNA through interaction with the AR mRNA coding sequence showing that miR-31, or a fragment thereof has the ability to act as a novel therapeutic agent in treating cancer. The current disclosure also shows that AR indirectly represses miR-31 expression by binding to the miR-31 promoter region and modulating methyltransferase activity. Another aspect of the current disclosure shows that miR-31 indirectly modulates AR activity by modulating regulators of cell cycle progression. The disclosure further provides an isolated nucleic acid that modulates the activity of the androgen receptor in a cell.
    Type: Application
    Filed: April 12, 2013
    Publication date: April 16, 2015
    Applicant: CORNELL UNIVERSITY
    Inventors: Pei-Chun Lin, Mark A. Rubin
  • Patent number: 8969527
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: March 3, 2015
    Assignees: The Regents of the University of Michigan, The Brigham and Women's Hospital, Inc.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Publication number: 20140037647
    Abstract: Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN define a distinct subgroup of prostate cancer that is predisposed to the development of lethal NEPC, who will benefit from early intervention.
    Type: Application
    Filed: March 28, 2012
    Publication date: February 6, 2014
    Applicant: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Himisha Beltran
  • Publication number: 20130331279
    Abstract: The invention relates generally to new prostate cancer markers, and particularly to a class of cancer marked by the presence of missense mutations in SPOP, an E3 ubiquitin ligase component. The invention provides methods and materials for detecting and diagnosing prostate cancer by detecting these mutations and may be useful in predicting disease progression and response to therapy.
    Type: Application
    Filed: February 9, 2012
    Publication date: December 12, 2013
    Applicant: CORNELL UNIVERSITY
    Inventors: Mark A. Rubin, Christopher Barbieri
  • Patent number: 8580509
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: November 12, 2013
    Assignees: The Regents of The University of Michigan, The Brigham and Women's Hospital, Inc.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis