Abstract: Disclosed is a balloon catheter having an inflatable balloon having a radiation carrier such as a radiation delivery layer thereon. In one embodiment, the radiation delivery layer comprises one or more layers of metal foil, such as gold. The foil is irradiated, and the balloon is thereafter positioned at a treatment site in a vessel and expanded to bring the metal foil layer into close proximity with the vessel wall. In another embodiment, the radiation carrier is in the form of a dopant in the balloon material. Methods of using the balloon include radiation dosing a site following a balloon dilatation or other procedure, and simultaneously performing balloon angioplasty and radiation dosing.

Abstract: A medical device applies radiant energy to tissue surrounding or underlying the surface of a duct, hollow organ or body cavity. The energy is emitted through an expandable, energy-transmissive balloon in which a fluid coolant is circulated to cool the surface of the duct, hollow organ or body cavity and the tissue immediately underlying the surface of the duct, hollow organ or body cavity. The device includes an elongated transmission line extending through a catheter, having a proximal end portion, which is connectable to a source of radiant energy, and a distal end portion, to which a radiant energy emitter is coupled. The balloon is mounted on the distal end of the catheter and extends over the emitter. The catheter contains an inlet confined fluid passageway and an outlet confined fluid passageway to provide fluid coolant circulation through the balloon. Microscopic albumen microspheres or particles of quartz or silica are suspended in the fluid coolant to more uniformly diffuse the radiant energy.

Abstract: Disclosed is a balloon catheter having an inflatable balloon having a radiation carrier such as a radiation delivery layer thereon. In one embodiment, the radiation delivery layer comprises one or more layers of metal foil, such as gold. The foil is irradiated, and the balloon is thereafter positioned at a treatment site in a vessel and expanded to bring the metal foil layer into close proximity with the vessel wall. In another embodiment, the radiation carrier is in the form of a dopant in the balloon material. Methods of using the balloon include radiation dosing a site following a balloon dilatation or other procedure, and simultaneously performing balloon angioplasty and radiation dosing.

Abstract: Disclosed is a balloon catheter having an inflatable balloon having a radiation carrier such as a radiation delivery layer thereon. In one embodiment, the radiation delivery layer comprises one or more layers of metal foil, such as gold. The foil is irradiated, and the balloon is thereafter positioned at a treatment site in a vessel and expanded to bring the metal foil layer into close proximity with the vessel wall. In another embodiment, the radiation carrier is in the form of a dopant in the balloon material. Methods of using the balloon include radiation dosing a site following a balloon dilatation or other procedure, and simultaneously performing balloon angioplasty and radiation dosing.