Abstract: The invention relates to a liquid concentrate comprising a plant growth regulator like prohexadione dissolved in an ionic liquid, the ionic liquid comprising an organic base and a strong acid. The ionic liquid may comprise an amine, amide, imine, imide or urea. The strong acid preferably is ethephon.

Abstract: The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of NETs in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating NET mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRI)). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of NET mediated ailments. For example, the present invention relates to methods and uses of ?-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS.

Abstract: A box blade grading attachment of the present disclosure may comprise an attachment frame, a coupler bracket, a tilt connection, a pivot beam, left and right caster wheels, a grading box, and a tilting actuator. The attachment frame includes a rear attachment frame portion for coupling of the box blade grading attachment to a construction machine and an upper attachment frame portion having an upward facing reference surface. The tilt connection defines a tilt axis about which the attachment frame may tilt relative to the coupler bracket. The tilt axis may be substantially parallel to the upward facing reference surface. The pivot beam is pivotally connected to the upper attachment frame portion and includes left and right caster wheels pivotally connected to the pivot beam. The tilting actuator tilts the attachment frame and the grading box about the tilt axis relative to the coupler bracket.

Abstract: A pharmaceutical product for administration of an anti TROP2 antibody-drug conjugate in combination with an ATR inhibitor is provided. The anti-TROP2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an anti-TROP2 antibody) is conjugated to an anti-TROP2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the anti-TROP2 antibody-drug conjugate and the ATR inhibitor are administered in combination to a subject: Formula (I).

Abstract: A utility consumption information system may generate a variety of data that is based on and/or derived from utility consumption or usage associated with a site. In some examples, the utility consumption information system may generate data to be provided or displayed by applying a load profile to utility consumption or usage data obtained at the site over a period of time. The utility consumption information system may generate the load profile based on sample interval data obtained from one or more devices (e.g., utility metering devices) sharing characteristics with the site at which the utility consumption or usage data was obtained.

Abstract: A quick loader includes a propellant tube, a main loader body, a funnel valve, and a funnel tube. The funnel valve features a channel that connects the main loader body to the funnel tube, allowing propellant to flow therethrough when open. The funnel valve is coupled to the main loader body by a hinge on a metal pin that enables free rotation around a fixed axis. The funnel valve further features a gasket that covers an outlet of the main loader body when not in use and prevents water from entering the propellant tube. In some embodiments, the quick loader further includes a bullet compartment and a primer holder, configured respectively to hold a bullet and a primer that are accessible with one hand for quick and silent use in the field.

Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.

Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.

Abstract: An implantable sensor device includes a sensor-support substrate, a microelectromechanical systems (MEMS) pressure sensor device mounted to the sensor-support substrate, a transduction medium applied over the pressure sensor device, and a biocompatibility layer applied over the transduction medium

Abstract: A steerable micro-endoscope comprising a cylindrical elongated member having at least a first lumen, a tensioning wire running in the first lumen and attached at the distal end of the elongated member; the elongated member having a proximal portion and a distal portion, having respectively a first durometer and a second durometer lower than the first durometer; the first lumen being arranged such that the distal portion of the elongated body bends when the tensioning wire is pulled; wherein the elongated member comprises a second lumen; an electrode wire being arranged in the second lumen such that the distal end of the electrode wire does not protrude from the distal portion of the elongated member when the elongated member is not bent, and such that the distal end of the electrode wire protrudes from the distal portion of the elongated member when the elongated member is bent.

Abstract: The invention generally relates to an electric vehicle having an electric motor and a pack for storing energy, said vehicle configured having: at least two passenger seats, including a first seat, and a second seat, positioned behind the front seat and configured to face rearward; and the pack having: a lateral module configured to extend perpendicularly to the longitudinal axis of the vehicle between the first seat and the second seat.

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port and outlet port, at least one fluid cooling chamber having at least one inlet port and outlet port, one or more UV radiation sources coupled to the irradiation chamber(s); and at least one heat exchange mechanism thermally coupled to the radiation source(s) and the cooling chamber(s). At least a portion of the interior surface of the cooling chamber(s) may comprise at least a portion of the exterior surface of the irradiation chamber(s) so the cooling chamber(s) is in fluid communication with the irradiation chamber(s).

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port, one or more UV radiation sources inside the irradiation chamber(s) optically coupled to the fluid in the irradiation chamber(s) via at least one UV-transparent window in contact with the fluid; one or more seals or gaskets disposed adjacent to the radiation sources to protect them from the fluid; and at least one heat exchange mechanism inside the irradiation chamber(s) thermally coupled to the radiation sources and to the fluid. The UV radiation sources and the at least one heat exchange mechanism are at least partially submerged in the fluid in the irradiation chamber.

Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.

Abstract: A valve piston has a central axis along which mutually spaced control geometries are provided, which are bypassed by a passage that extends through the valve piston. The valve piston is, at least in portions, manufactured additively. A valve is includes a valve housing and a housing recess, in which the valve piston is received so that it is adjustable relative to the valve housing.

Abstract: Provided are roofing granules, such as algaecidal roofing granules, methods for making them and their use in roofing products. In one aspect, the disclosure provides an algaecidal roofing granule that comprises an ion-exchanged zeolite disposed within the binder, wherein the ion-exchanged zeolite comprises algaecidal ions.

Abstract: Apparatus (50) for fitting to an end of an internal wall, said apparatus (50) including a web portion (52) and a pair of legs (61, 63) extending from the web portion (52) in the same direction; at least one of the legs (61) in said pair of legs (61, 63) having a recess (56) that extends into a space formed by the web portion (52) and each of said legs (61, 63) such that a shadow line is created by the recess (56) near to the wall end in the overall finish of said wall.

Abstract: A method of managing an online support group to increase the odds that users will attain their wellness goals is disclosed. A request from a user to join a support group is received. A preference of the user with respect to a type of the support group is received. The support group is selected from a plurality of support groups based on the preference of the user and a preference of a member of the support group. Based on an acceptance by the user of an option to join the support group, the plurality of support groups is reorganized.

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port and outlet port, at least one fluid cooling chamber having at least one inlet port and outlet port, one or more UV radiation sources coupled to the irradiation chamber(s); and at least one heat exchange mechanism thermally coupled to the radiation source(s) and the cooling chamber(s). At least a portion of the interior surface of the cooling chamber(s) may comprise at least a portion of the exterior surface of the irradiation chamber(s) so the cooling chamber(s) is in fluid communication with the irradiation chamber(s).