Abstract: The disclosure provides dried compositions providing reagents for nucleic acid amplification, which are essentially free of inorganic salts. Lack of inorganic salts increases stability of such compositions and decreases formation of byproducts. Salts required for use of enzymes in the composition are supplied on reconstitution.

Abstract: The disclosures herein relate to novel compounds of formula wherein R1, R2, R3 and R4 are as defined herein, and their use in treating, preventing, ameliorating, controlling or reducing cerebrovascular or vascular disorders associated with CGRP receptor function.

Abstract: A method for notifying and mitigating a suboptimal event occurring in a transport climate control system that provides climate control to a climate controlled space of a transport unit is provided. The method includes monitoring an amount of power available for powering the transport climate control system, monitoring a power demand from the transport climate control system, and accessing operational data of the transport climate control system and the transport unit. The method also includes a controller determining whether a suboptimal event is detected based on one or more of the monitored amount of power available, the monitored power demand and the accessed operational data. Also, the method includes the controller generating a notification when a suboptimal event is detected, and the controller instructing the generated notification to be displayed on a display.

Abstract: A system configured to be coupled with a participant of an activity. The system comprises: a participant activity monitoring unit configured for monitoring a performance of the activity by the participant; an activity information module configured for storing performance information corresponding to the activity; and a participant performance correlator configured for delivering comparative performance data based on the monitored performance of the activity by the participant and the stored performance information.

Abstract: Aspects described herein may relate to aerial structures such as aircraft. An aerial structure may include a fuselage, a wing attached to the fuselage, and a plurality of propulsion systems configured to generate thrust. A propulsion system may include a plurality of propulsors, such as propulsor fans. A propulsor fan may be configured to be actuated between a conventional take-off and landing (CTOL) flight mode, a short take-off and landing (STOL) flight mode, and a vertical take-off and landing (VTOL) flight mode.

Abstract: A facility for procuring and analyzing information about an anatomical surface feature from a caregiver that is usable to generate an assessment of the surface feature is described. The facility displays information about the surface feature used in the assessment of the surface feature. The facility obtains user input and/or data generated by an image capture device to assess the surface feature or update an existing assessment of the surface feature.

Abstract: Disclosed herein is a computer-implemented method comprising: aggregating option evaluation data for a plurality of options and for a plurality of predefined criteria; graphically displaying the user modifiable chart comprising the plurality of graphical representations of the aggregated option evaluation data, wherein: each graphical representation depicts data points visually plotted with weights, the plurality of graphical representations for the plurality of predefined criteria are visually ordered according to a rank of the plurality of predefined criteria, and the weights are based on the rank of the plurality of predefined criteria; detecting a first user input modifying the rank of at least one predefined criterion; in accordance with the first user input, automatically updating the weights of the data points; and displaying an updated user modifiable chart comprising the plurality of graphical representations of the aggregated option evaluation data.

Abstract: The present invention provides methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators, and compositions having low impurity levels.

Abstract: A method and system to convert user activities performed in a real world into virtual world activity. The system includes a virtual world environment with a virtual activity tracker to obtain virtual activity performance data for an activity performed by a user in the virtual world environment; and a virtual world database to store the virtual activity performance data in a virtual profile of the user. The system also includes a real world activity tracker to obtain real world activity performance data for a real world activity performed by the user; and an activity convertor to convert the real world activity performance data into an amount of converted virtual activity performance data and add the converted virtual activity performance data to the virtual profile of the user.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: An electronic automatically decoupling hub assembly. The decoupling hub assembly has an axle and a hub shell rotationally positioned about the axle. A controller provides automatic activation/deactivation signals to an inductor. The decoupling hub assembly has a bearing rotationally positioned about the axle and a cassette body assembly, having a plurality of teeth, rotationally positioned about the bearing. One or more pawls are provided to engage with at least some of the teeth of the cassette body assembly and a seal is used to contain the pawls within the decoupling hub assembly. A cassette body assembly is coupled with the ratchet ring and an end cap is used to prevent a contaminant from entering into the decoupling hub assembly.

Abstract: Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.

Abstract: A drone is disclosed having a low acoustic signature. The drone includes a fuselage, a main inboard wing attached to the fuselage, a pylon located towards an aft end of the fuselage and having an end that is higher than the main inboard wing, and a propulsor connected to the pylon and situated above the fuselage. The drone includes a plurality of booms connected to the main inboard wing and a plurality of horizontal tails attached to the plurality of booms. The horizontal tails have an outboard tail arrangement and are tiltable.

Abstract: The invention enables digital music content to be downloaded to and used on a portable wireless computing device. An application running on the wireless device has been automatically adapted to parameters associated with the wireless device without end-user input (e.g. the application has been configured in dependence on the device OS and firmware, related bugs, screen size, pixel number, security models, connection handling, memory etc., This application enables an end-user to browse and search music content on a remote server using a wireless network; to download music content from that remote server using the wireless network and to playback and manage that downloaded music content. The application also includes a digital rights management system that enables unlimited legal downloads of different music tracks to the device and also enables any of those tracks stored on the device to be played so long as a subscription service has not terminated.

Abstract: Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.

Abstract: Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.

Abstract: Systems and methods are provided for providing energy consumption feedback for powering a transport climate control system using external data. This can include determining whether an energy level of an energy storage source is greater than an expected energy consumption of a transport climate control system during a route, based on route parameters and route conditions. The route conditions may be obtained from a source such as a remote server, and include data such as weather data, traffic data, or the like. The systems and methods may further compare current energy levels to an updated predictions of energy consumption during transit to determine if the energy level is sufficient to complete the route and alert the user when the energy level is insufficient to complete the route.

Abstract: A decorated laminate including: an outer ply; an inner ply; a polymer interlayer between the inner ply and the outer ply; and organic ink printed decoration on one or both of internal surfaces of the laminate between the outer ply and the polymer interlayer or between the inner ply and polymer interlayer, wherein the decorated laminate has a stone impact resistance as defined herein. Also disclosed is a method of making and using the decorated laminate.

Abstract: Disclosed are embodiments of a vacuum chuck. The vacuum chuck includes a forming surface having a first longitudinal end, a second longitudinal end, and a curved region. The first longitudinal end and the second longitudinal end define a longitudinal axis, and the curved region defines a radius of curvature along the longitudinal axis. A plurality of elongate grooves are formed into the forming surface in the curved region. Each elongate groove of the plurality of elongate grooves has a length, a width, and a depth extending into the forming surface. The length of each elongate groove is greater than the width. At least one conduit is configured for connection to a vacuum source and is disposed beneath the forming surface. The at least one conduit extends transversely across the plurality of elongate grooves, and the at least one conduit is in fluid communication with the plurality of elongate grooves.