Abstract: The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.

Abstract: The principles and embodiments of the present disclosure relate generally to complexly curved laminates made from a complexly curved substrate and a flat substrate, such as automotive window glazings, and methods of cold forming complexly-curved glass products from a curved substrate and a flat substrate. In one or more embodiments, the laminate includes first complexly-curved glass substrate with a first surface and a second surface opposite the first surface, a second complexly-curved glass substrate with a third surface and a fourth surface opposite the third surface with a thickness therebetween; and a polymer interlayer affixed to the second convex surface and third surface, wherein the third surface and fourth surface have compressive stress values respectively that differ such that the fourth surface has as compressive stress value that is greater than the compressive stress value of the third surface.

Abstract: An apparatus including a photonic physically unclonable function (PUF) device for processing an initial optical mode distribution based on a challenge C and outputting a final optical mode distribution, the photonic PUF device includes optical mode waveguides for forming or supporting optical modes to which the initial optical mode distribution is provided and from which the final optical mode distribution is produced. Optical mode mixing layers are spaced apart along, and coupled to, the optical mode waveguides to mix the optical modes received by each optical mode mixing layer so that the optical mode distribution leaving each optical mode mixing layer is different to the optical mode distribution received by each optical mode mixing layer.

Abstract: Disclosed herein is a computer-implemented method comprising: aggregating option evaluation data for a plurality of options and for a plurality of predefined criteria; graphically displaying the user modifiable chart comprising the plurality of graphical representations of the aggregated option evaluation data, wherein: each graphical representation depicts data points visually plotted with weights, the plurality of graphical representations for the plurality of predefined criteria are visually ordered according to a rank of the plurality of predefined criteria, and the weights are based on the rank of the plurality of predefined criteria; detecting a first user input modifying the rank of at least one predefined criterion; in accordance with the first user input, automatically updating the weights of the data points; and displaying an updated user modifiable chart comprising the plurality of graphical representations of the aggregated option evaluation data.

Abstract: A drone is disclosed having a low acoustic signature. The drone includes a fuselage, a main inboard wing attached to the fuselage, a pylon located towards an aft end of the fuselage and having an end that is higher than the main inboard wing, and a propulsor connected to the pylon and situated above the fuselage. The drone includes a plurality of booms connected to the main inboard wing and a plurality of horizontal tails attached to the plurality of booms. The horizontal tails have an outboard tail arrangement and are tiltable.

Abstract: The disclosed technology relates to a process of evaluating any number of different identity providers (IDPs) and their respective set of credentials that are used to authenticate corresponding users to assist with the onboarding of the different IDPs in connection with Wi-Fi identity federations. In particular, the process allows a person's electronic identity and attributes (stored across one or more IDPs) to be determined once using a standard. Once trust has been established for the user, that trust can then be utilized across a number of different systems (e.g., Single-sign on). The same trust determination can be used without the need for the authenticity of the user identity to be re-evaluated with each new access request.

Abstract: An example virtualized computing system includes: a host cluster having hosts and a virtualization layer executing on hardware platforms of the hosts, the virtualization layer supporting execution of virtual machines (VMs); an orchestration control plane integrated with the virtualization layer, the orchestration control plane including a master server executing in a first VM of the VMs; guest cluster infrastructure software (GCIS) executing in the master server, the GCIS configured to create a set of objects defining a container orchestration cluster, and manage lifecycles of second VMs of the VMs based on state of the set of objects; and guest software executing in the second VMs to implement the container orchestration cluster as a guest cluster of the host cluster, the guest software having components that interface with the GCIS.

Abstract: An aircraft may comprise ducted fans. The ducted fans may be an array of ducted fans. An array of ducted fans may be integrated in a wing of the aircraft. A ducted fan may be integrated in a horizontal tail of the aircraft. The wing may include a movable edge, such as a flap, to provide both exhaust area and flow turning control. The movable edge may be articulated by pivoting the movable edge. The movable edge may be extended and retracted.

Abstract: The disclosed technology relates to a process of evaluating any number of different identity providers (IDPs) and their respective set of credentials that are used to authenticate corresponding users to assist with the onboarding of the different IDPs in connection with Wi-Fi identity federations. In particular, the process allows a person's electronic identity and attributes (stored across one or more IDPs) to be determined once using a standard. Once trust has been established for the user, that trust can then be utilized across a number of different systems (e.g., Single-sign on). The same trust determination can be used without the need for the authenticity of the user identity to be re-evaluated with each new access request.

Abstract: Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.

Abstract: Airborne LiDAR bathymetry systems and methods of use are provided. The airborne LiDAR bathymetry system can collect topographic data and bathymetric data at high altitudes. The airborne LiDAR bathymetry system has a receiver system, a detector system, and a laser transmission system.

Abstract: According to some embodiments, a method performed by a classification scanner comprises receiving an electronic message and determining a classification that applies to the electronic message. The classification is determined based on an express indication from a user. The method further comprises providing a machine learning trainer with the electronic message and an identification of the classification that applies to the electronic message. The machine learning trainer is adapted to determine a machine learning policy that associates attributes of the electronic message with the classification.

Abstract: Devices, systems, and methods for combinatorial treatment of a condition with an implantable damping device and therapeutic agent (e.g., drug) are disclosed herein. Methods for treating one or more effects of the condition, such as a neurological condition, include providing the implantable damping device and at least one other therapy, such as a therapeutic agent, that treats the condition to the patient. The implantable damping device includes a flexible damping member and an abating substance and can be placed in apposition with a blood vessel. The flexible damping member forms a generally tubular structure having an inner and an outer surface, the inner surface formed of a sidewall having a partially deformable portion. The abating substance is disposed within the partially deformable portion and moves longitudinally and/or radially within the partially deformable portion in response to pulsatile blood flow.

Abstract: Systems and methods are provided for providing a consistent experience for users of cloud-based block storage volumes. While cloud storage aims to remove hardware considerations for an end user's experience, block storage performance can nevertheless vary according to the underlying hardware used to support a volume or the specific network location of that hardware. Embodiments of the present disclosure address that inconsistent performance by associating a volume with a performance profile that sets a target latency for the volume. A storage client can then monitor observed latency for the volume and inject synthetic latency into input/output operations for the volume as calculated via a proportional-integral-derivative algorithm, such that the observed latency matches the target within the performance profile. This enables the cloud provider to vary physical hardware or network configurations without effect on block storage performance from the point of view of an end user.

Abstract: In one aspect, a method for enabling EPCS in a network includes receiving a request from a network device to establish a connection to the network, wherein the request indicates an emergency event and at least one user equipment associated with the emergency event; prioritizing, for the network device, access to the network based on the request in accordance with a resource allocation policy comprising a plurality of access levels associated with a plurality of EPCS groups; allocating network resources in accordance with the resource allocation policy to the network device, wherein the one or more network resources are configured to modify a set of attributes of the network device to grant the network device an increased priority related to the emergency event; and transmitting a message to the network device to indicate authorization for the network device to establish a connection with the network according to the increased priority.

Abstract: Disclosed herein are methods and systems for selectively managing different temporal and/or spatial resolution images and metadata collected during a transmission electron microscope (TEM) session. The system includes a transmission electron microscope and a computer system communicatively coupled to the transmission electron microscope. The computer system includes memory, data storage, and at least one processor configured for continuously receiving, from the transmission electron microscope, data captured at a lower temporal and/or spatial resolution and selectively receiving, from the transmission electron microscope, data captured at a higher temporal and/or spatial resolution.

Abstract: A system configured to be coupled with a participant of an activity. The system comprises: a participant activity monitoring unit configured for monitoring a performance of the activity by the participant; an activity information module configured for storing performance information corresponding to the activity; and a participant performance correlator configured for delivering comparative performance data based on the monitored performance of the activity by the participant and the stored performance information.

Abstract: A method and system to convert user activities performed in a real world into virtual world activity. The system includes a virtual world environment with a virtual activity tracker to obtain virtual activity performance data for an activity performed by a user in the virtual world environment; and a virtual world database to store the virtual activity performance data in a virtual profile of the user. The system also includes a real world activity tracker to obtain real world activity performance data for a real world activity performed by the user; and an activity convertor to convert the real world activity performance data into an amount of converted virtual activity performance data and add the converted virtual activity performance data to the virtual profile of the user.

Abstract: Disclosed herein is a computer-implemented method comprising: aggregating option evaluation data for a plurality of options and for a plurality of predefined criteria; graphically displaying the user modifiable chart comprising the plurality of graphical representations of the aggregated option evaluation data, wherein: each graphical representation depicts data points visually plotted with weights, the plurality of graphical representations for the plurality of predefined criteria are visually ordered according to a rank of the plurality of predefined criteria, and the weights are based on the rank of the plurality of predefined criteria; detecting a first user input modifying the rank of at least one predefined criterion; in accordance with the first user input, automatically updating the weights of the data points; and displaying an updated user modifiable chart comprising the plurality of graphical representations of the aggregated option evaluation data.