Patents by Inventor Mark A. Stremler
Mark A. Stremler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20120003729Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: ApplicationFiled: July 1, 2011Publication date: January 5, 2012Applicant: VANDERBILT UNIVERSITYInventors: John P. Wikswo, Franz J. Baudenbacher, Ales Prokop, Eugene J. Leboeuf, Chang Y. Chung, David Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler
-
Publication number: 20110294202Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber.Type: ApplicationFiled: May 26, 2011Publication date: December 1, 2011Applicant: VANDERBILT UNIVERSITYInventors: John P. Wikswo, Franz J. Baudenbacher, David Cliffel, Frederick R. Haselton, Eugene J. Leboeuf, Ales Prokop, Randall S. Reiserer, Mark A. Stremler
-
Patent number: 8003378Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: GrantFiled: March 5, 2009Date of Patent: August 23, 2011Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Ales Prokop, Eugene LeBoeuf, Chang Y. Chung, David E. Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler
-
Patent number: 7977089Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber.Type: GrantFiled: August 27, 2003Date of Patent: July 12, 2011Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, David Cliffel, Frederick R. Haselton, Eugene J. Leboeuf, Ales Prokop, Randall S. Reiserer, Mark A. Stremler
-
Patent number: 7790443Abstract: A bioreactor with substance injection capability. In one embodiment, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a chamber for receiving cells and a liquid medium. A port is formed in the second substrate between the bottom surface and the first surface of the second substrate. As formed, the port is in fluid communication with the chamber to allow a stream of substance to be introduced into the chamber. The stream of substance is controlled so as to provide a gradient, or a concentration gradient of the substance, to the chamber.Type: GrantFiled: August 27, 2003Date of Patent: September 7, 2010Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Mark A. Stremler, Alissa Weaver
-
Publication number: 20090215654Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: ApplicationFiled: March 5, 2009Publication date: August 27, 2009Applicant: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Ales Prokop, Eugene J. Leboeuf, Chang Y. Chung, David Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler
-
Patent number: 7534601Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: GrantFiled: August 27, 2003Date of Patent: May 19, 2009Assignee: Vanderbilt UniversityInventors: John P. Wikswo, Franz J. Baudenbacher, Alex Prokop, Eugene J. Leboeuf, Chang Y. Chung, David Cliffel, Frederick R. Haselton, William H. Hofmeister, Charles P. Lin, Lisa J. McCawley, Randall S. Reiserer, Mark A. Stremler
-
Publication number: 20060166354Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber.Type: ApplicationFiled: August 27, 2003Publication date: July 27, 2006Applicant: VANDERBILT UNIVERSITYInventors: John Wikswo, Franz Baudenbacher, David Cliffel, Frederick Haselton, Eugene Leboeuf, Alex Prokop, Randall Reiserer, Mark Stremler
-
Publication number: 20060154361Abstract: A bioreactor with substance injection capability. In one embodiment, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a chamber for receiving cells and a liquid medium. A port is formed in the second substrate between the bottom surface and the first surface of the second substrate. As formed, the port is in fluid communication with the chamber to allow a stream of substance to be introduced into the chamber. The stream of substance is controlled so as to provide a gradient, or a concentration gradient of the substance, to the chamber.Type: ApplicationFiled: August 27, 2003Publication date: July 13, 2006Inventors: John Wikswo, Franz Baudenbacher, Frederick Haselton, William Hofmeister, Charles Lin, Lisa McCawley, Mark Stremler, Alissa Weaver
-
Publication number: 20060141607Abstract: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.Type: ApplicationFiled: August 27, 2003Publication date: June 29, 2006Inventors: John Wikswo, Franz Baudenbacher, Alex Prokop, Eugene Leboeuf, Chang Chung, David Cliffel, Frederick Haselton, William Hofmeister, Charles Lin, Lisa McCawley, Randall Reiserer, Mark Stremler
-
Publication number: 20060073539Abstract: An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical quantity related to at least one of the cellular physiological activities of the cell, and identifying the agent from the measured response. The method further includes the step of quantifying the agent from the measured response.Type: ApplicationFiled: August 6, 2002Publication date: April 6, 2006Inventors: John Wikswo, Franz Baudenbacher, R. Balcarcel, Theodore Bapty, David Cliffel, Sven Eklund, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Stremler, Andreas Werdich, Yang Yuansheng
-
Publication number: 20040248125Abstract: A system 10 is provided for improved microarray biomolecular analysis. A microarray 36 is placed in a shallow chamber 20, and an induced motion of test fluid through the chamber is achieved by a sequential series of pulses directed to a plurality of source-sink pairs.Type: ApplicationFiled: July 26, 2004Publication date: December 9, 2004Inventors: Mark A Stremler, Timothy S. Fisher, Frederick R. Haselton, David K. Schaffer, Mark McQuain