Abstract: Provided are systems and methods for predicting a travel range of a vehicle. The method comprises receiving, using at least one processor, travel information associated with the vehicle, receiving, using the at least one processor, a weather forecast and a traffic forecast associated with the travel information, and predicting, using the at least one processor, the predicted travel range based at least in part on a battery charge level of the vehicle, the weather forecast, and the traffic forecast. In embodiments, the predicted travel range may be based on current and historical battery charge levels, current and/or historical battery discharge rates, weather forecast data, and traffic forecast data.

Abstract: The disclosures herein relate to compounds of Formula (1?): or a salt thereof, wherein A, Q, X, Z, L, R2, R3 and R9 are defined herein, and their use in the treatment of SARS-CoV-2 and related viruses and disorders associated with SARS-CoV-2: Mpro.

Abstract: Peel-away introducer sheath (100) having an adjustable diameter. The present disclosure is directed generally to introducer sheaths used in endoluminal catheterization for medical treatments. More particularly, the present disclosure is directed towards introducer sheaths that are expandable and can be peeled apart.

Abstract: The present invention provides an integrated process for carbon dioxide capture, sequestration and utilisation, which comprises: a) providing an aqueous slurry comprising an aqueous liquid and a particulate solid comprising an activated magnesium silicate mineral; b) in a dissolution stage, contacting a CO2-containing gas stream with the aqueous slurry at a first pressure to dissolve magnesium from the mineral to provide a slurry comprising a magnesium ion enriched carbonated aqueous liquid and a magnesium depleted solid residue; and c) in a precipitation stage, precipitating magnesium carbonate from magnesium ions dissolved in step b) by multiple successive stage-wise reductions in pressure, with each stage being at a lower pressure than the preceding stage; wherein each successive stage-wise reduction in pressure releases CO2 which is correspondingly stage-wise compressed and recycled back into the dissolution stage.

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

Abstract: The present invention describes an integrated process for carbon dioxide capture, sequestration and utilisation, which comprises: a) providing an aqueous slurry comprising an aqueous solution and a particulate solid comprising an activated magnesium silicate mineral; b) in a dissolution stage, contacting a CO2-containing gas stream with the aqueous slurry to dissolve magnesium from the mineral to provide a magnesium ion enriched aqueous solution and a magnesium depleted solid residue; c) recovering at least a portion of the magnesium depleted solid residue; d) in a separate acid treatment stage, reacting the recovered portion of the magnesium depleted solid residue with a solution comprising a mineral acid or acid salt to further dissolve magnesium and other metals and to provide an acid-treated solid residue; e) recovering the acid-treated solid residue; and f) in a separate precipitation stage, precipitating magnesium carbonate from the magnesium ion enriched aqueous solution.

Abstract: The present description provides improved methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro. Also provided are isolated invitro cell populations, compositions, and systems comprising TEP cells produced in vitro. Compositions and systems of cell populations of thymic epithelial cells and subpopulations thereof, as well as cells formed during different stages of differentiation of PS cells into thymic epithelial cells and subpopulations thereof are provided.

Abstract: A materials handling vehicle including a load handling assembly having a mast assembly, and a fork carriage assembly including a fork support and at least one fork assembly, the at least one fork assembly including a first fork member, which is fixed to the fork support, and a second fork member. The vehicle includes a tilt assembly that tilts the fork support relative to the mast assembly such that a central axis of the at least one fork assembly is positionable in a plurality of different positions relative to a horizontal direction. The vehicle includes a fork extension/retraction assembly that moves the second fork member relative to the first fork member in a first direction that is parallel to the central axis such that the fork extension/retraction assembly selectively moves the second fork member toward or away from the fork support in the first direction.

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

Abstract: Examples provide a method and apparatus for fastener pin removal. A fastener pin removal tool includes a tool body having a workpiece interface surface, a threaded hole and opposing side edges. A fitting is coupled to the end of the threaded screw that is proximate the workpiece interface surface. The fitting includes a keyhole-slot configured to receive the head of a pin. The keyhole-slot defines a set of spaced-apart jaws configured to engage the head of the pin that is received within the keyhole-slot. A rotational end-piece is coupled to the threaded screw and rotates to cause the fitting and the set of spaced-apart jaws to pull the head of the pin received within the keyhole-slot. As the rotational end-piece pulls the pin head, the pin is removed from a workpiece.

Abstract: An integrated process for carbon dioxide capture, sequestration and utilization, includes a) providing an aqueous slurry with a particulate solid including an activated magnesium silicate mineral; b) contacting a CO2-containing gas stream with the aqueous slurry to provide a slurry comprising a magnesium ion enriched carbonated aqueous liquid and a magnesium depleted solid residue; c) subjecting at least part of the magnesium depleted solid residue to a particle size classification process that separates the magnesium depleted solid residue into a fine particle size fraction and a coarse particle size fraction; d) subjecting the coarse particle size fraction to a particle size reduction process; e) providing an aqueous slurry comprising particle size reduced fraction from step d) and repeating step b), wherein this step e) does not include using fine particle size fraction from step c); and f) precipitating magnesium carbonate from magnesium ions dissolved in b) and e).

Abstract: The present invention provides an integrated process for carbon dioxide capture, sequestration and utilisation, which comprises: a) providing an aqueous slurry comprising an aqueous liquid and a particulate solid comprising an activated magnesium silicate mineral; b) in a dissolution stage, contacting a CO2-containing gas stream with the aqueous slurry at a first pressure to dissolve magnesium from the mineral to provide a slurry comprising a magnesium ion enriched carbonated aqueous liquid and a magnesium depleted solid residue; and c) in a precipitation stage, precipitating magnesium carbonate from magnesium ions dissolved in step b) by multiple successive stage-wise reductions in pressure, with each stage being at a lower pressure than the preceding stage; wherein each successive stage-wise reduction in pressure releases CO2 which is correspondingly stage-wise compressed and recycled back into the dissolution stage.

Abstract: Examples provide a method and apparatus for fastener pin removal. A fastener pin removal tool includes a tool body having a workpiece interface surface, a threaded hole and opposing side edges. A fitting is coupled to the end of the threaded screw that is proximate the workpiece interface surface. The fitting includes a keyhole-slot configured to receive the head of a pin. The keyhole-slot defines a set of spaced-apart jaws configured to engage the head of the pin that is received within the keyhole-slot. A rotational end-piece is coupled to the threaded screw and rotates to cause the fitting and the set of spaced-apart jaws to pull the head of the pin received within the keyhole-slot. As the rotational end-piece pulls the pin head, the pin is removed from a workpiece.

Abstract: An integrated process for carbon dioxide capture, sequestration and utilization, includes a) providing an aqueous slurry with a particulate solid including an activated magnesium silicate mineral; b) contacting a CO2-containing gas stream with the aqueous slurry to provide a slurry comprising a magnesium ion enriched carbonated aqueous liquid and a magnesium depleted solid residue; c) subjecting at least part of the magnesium depleted solid residue to a particle size classification process that separates the magnesium depleted solid residue into a fine particle size fraction and a coarse particle size fraction; d) subjecting the coarse particle size fraction to a particle size reduction process; e) providing an aqueous slurry comprising particle size reduced fraction from step d) and repeating step b), wherein this step e) does not include using fine particle size fraction from step c); and f) precipitating magnesium carbonate from magnesium ions dissolved in b) and e).

Abstract: The present invention describes an integrated process for carbon dioxide capture, sequestration and utilisation, which comprises: a) providing an aqueous slurry comprising an aqueous solution and a particulate solid comprising an activated magnesium silicate mineral; b) in a dissolution stage, contacting a CO2-containing gas stream with the aqueous slurry to dissolve magnesium from the mineral to provide a magnesium ion enriched aqueous solution and a magnesium depleted solid residue; c) recovering at least a portion of the magnesium depleted solid residue; d) in a separate acid treatment stage, reacting the recovered portion of the magnesium depleted solid residue with a solution comprising a mineral acid or acid salt to further dissolve magnesium and other metals and to provide an acid-treated solid residue; e) recovering the acid-treated solid residue; and f) in a separate precipitation stage, precipitating magnesium carbonate from the magnesium ion enriched aqueous solution.

Abstract: The present disclosure relates to methods and kits for detecting a nucleic acid or antigen in a sample using a universal array platform. For example, a nucleic acid can be detected by amplifying at least a portion of a nucleic acid from a sample using a primer pair comprising a first primer comprising a label and a first oligonucleotide sequence that hybridizes with a first strand of the portion of the nucleic acid and a second primer comprising a second oligonucleotide sequence that hybridizes with a second strand of the portion of the nucleic acid; contacting the amplicon, if present, to a plurality of single-stranded oligonucleotide capture sequences each affixed to a solid support; applying a colloidal detection reagent to the solid supports; washing the solid supports with a wash solution; and detecting the colloidal detection reagent. The present disclosure further relates to specific capture and tether oligonucleotide sequences.

Abstract: A materials handling vehicle including a load handling assembly having a mast assembly, and a fork carriage assembly including a fork support and at least one fork assembly, the at least one fork assembly including a first fork member, which is fixed to the fork support, and a second fork member. The vehicle includes a tilt assembly that tilts the fork support relative to the mast assembly such that a central axis of the at least one fork assembly is positionable in a plurality of different positions relative to a horizontal direction. The vehicle includes a fork extension/retraction assembly that moves the second fork member relative to the first fork member in a first direction that is parallel to the central axis such that the fork extension/retraction assembly selectively moves the second fork member toward or away from the fork support in the first direction.

Abstract: This application provides a process for mineral carbonation, which process comprises the steps of: providing a bed of hydroxylated magnesium silicate mineral particles in a heating vessel; agitating the bed of particles under conditions of a sub-atmospheric pressure and at a temperature of at least 600° C. to produce particles of dehydroxylated magnesium silicate mineral; and reacting the dehydroxylated magnesium silicate mineral with carbon dioxide, carbonate ions and/or bicarbonate ions to form magnesium carbonate. This application also provides a reactor system for carrying out the process, which includes (1) mineral from mine, (2) hydroxylated magnesium silicate mineral, (3) crushing, grinding, sizing, (4) agitated bed of particles, (5) external heating, (6) vacuum system, (7) from carbon source, (8) carbon dioxide or carbonate or bicarbonate ions in solution, (9) carbonation reactions, (10) carbonate product, (11) pre-heat, (12) heat recovery, and (13) magnetic fraction.

Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.

Abstract: This application provides a process for mineral carbonation, which process comprises the steps of: providing a bed of hydroxylated magnesium silicate mineral particles in a heating vessel; agitating the bed of particles under conditions of a sub-atmospheric pressure and at a temperature of at least 600° C. to produce particles of dehydroxylated magnesium silicate mineral; and reacting the dehydroxylated magnesium silicate mineral with carbon dioxide, carbonate ions and/or bicarbonate ions to form magnesium carbonate. This application also provides a reactor system for carrying out the process, which includes (1) mineral from mine, (2) hydroxylated magnesium silicate mineral, (3) crushing, grinding, sizing, (4) agitated bed of particles, (5) external heating, (6) vacuum system, (7) from carbon source, (8) carbon dioxide or carbonate or bicarbonate ions in solution, (9) carbonation reactions, (10) carbonate product, (11) pre-heat, (12) heat recovery, and (13) magnetic fraction.