Abstract: A method of alleviating or mitigating at least one symptom of migraine attack by administering to a patient suffering from a migraine attack a therapeutically effective amount of the compound of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: An intraocular lens (IOL) injector cartridge having one or more modifications from conventional designs which reduce stress and strain in the optic of the IOL during passage through the cartridge. One change includes adding axially-oriented ribs in a funnel portion of the cartridge to enable the cartridge wall to flex outward during passage of the IOL, which is compressed to a great degree in the cartridge lumen. Another modification involves providing a longitudinal step along a segment of the inner lumen which biases one free edge of the optic to tuck or dive under the other free edge and encourage spiral folding as the IOL progresses along the gradually narrowing lumen. The third option is modifying the shape of the lumen within the extreme distal end of the cartridge where the lumen is smallest so that it is neither circular nor oval. Each or all of these modifications may be incorporated into a single cartridge.

Abstract: Various embodiments of a feedthrough header assembly and a device including such assembly are disclosed. The assembly includes a header having an inner surface and an outer surface; a dielectric substrate having a first major surface and a second major surface, where the second major surface of the dielectric substrate is disposed adjacent to the inner surface of the header; and a patterned conductive layer disposed on the first major surface of the dielectric substrate, where the patterned conductive layer includes a first conductive portion and a second conductive portion electrically isolated from the first conductive portion. The assembly further includes a feedthrough pin electrically connected to the second conductive portion of the patterned conductive layer and disposed within a via that extends through the dielectric substrate and the header. The feedthrough pin extends beyond the outer surface of the header.

Abstract: A method is provided for forming a near-net thermoplastic composite component includes co-spraying a mixture comprising a thermoplastic polymer material and a chopped reinforcing material deposited onto at least one region associated with a tool having a first temperature and defining a near-net component shape. The mixture and adjacent tool is heated to a second temperature while the mixture is on the tool. The first temperature is below the solidification temperature of the thermoplastic polymer material and the second temperature is above the solidification temperature. Then, the mixture is exposed to a negative pressure to promote removal of gases from the mixture and put under compressive force to densify the mixture. The thermoplastic polymer material melts and flows. The tool is cooled to the first temperature and removing the mixture to form the near-net thermoplastic composite component having randomly oriented chopped reinforcement material distributed within a thermoplastic polymer matrix.

Abstract: A medical device includes a handle with a proximal arm and a distal arm. The proximal arm and the distal arm are pivotable via a joint. The medical device also includes a tube coupled to the distal arm and a drive wire. A distal portion of the drive wire includes an expandable end effector. A portion of the drive wire is positioned within the tube, and a different portion of the drive wire extends proximally of the distal arm and is coupled to the proximal arm.

Abstract: A medical device includes a handle with a proximal arm and a distal arm. The proximal arm and the distal arm are pivotable via a joint. The medical device also includes a tube coupled to the distal arm and a drive wire. A distal portion of the drive wire includes an expandable end effector. A portion of the drive wire is positioned within the tube, and a different portion of the drive wire extends proximally of the distal arm and is coupled to the proximal arm.

Abstract: A cargo storage compartment of a motor vehicle is arranged along a vehicle central axis. The cargo storage compartment includes a first side-wall and a second side-wall, each arranged parallel to the vehicle central axis, and a floor, together defining width, length, and height of the storage compartment. The cargo storage compartment also includes a cargo management assembly for moving objects in the cargo storage compartment along the vehicle central axis. The cargo management assembly also includes a first guide rail and a second guide rail arranged along the respective first and second side-walls. The assembly additionally includes a panel arranged between the first and second side-walls and transverse to the vehicle central axis. The panel is movably mounted on a panel axis to each of the first and second guide rails. The assembly further includes a mechanism configured to shift the panel along the first and second guide rails.

Abstract: A method is provided for forming a near-net thermoplastic composite component includes co-spraying a mixture comprising a thermoplastic polymer material and a chopped reinforcing material deposited onto at least one region associated with a tool having a first temperature and defining a near-net component shape. The mixture and adjacent tool is heated to a second temperature while the mixture is on the tool. The first temperature is below the solidification temperature of the thermoplastic polymer material and the second temperature is above the solidification temperature. Then, the mixture is exposed to a negative pressure to promote removal of gases from the mixture and put under compressive force to densify the mixture. The thermoplastic polymer material melts and flows. The tool is cooled to the first temperature and removing the mixture to form the near-net thermoplastic composite component having randomly oriented chopped reinforcement material distributed within a thermoplastic polymer matrix.

Abstract: Numerous devices are described. One device may comprise: a handle including a wire attachment portion; an actuator movably mounted to the handle, the actuator including a reaction chamber; a plunger movably mounted to the actuator, the plunger including a distal stop with a sheath attachment portion, and a proximal stop located in the reaction chamber; a resilient element including a distal end attached to the proximal stop, and a proximal end movable relative to plunger; and a force reduction element located in the reaction chamber between the resilient element and a reaction surface in the cavity. The resilient element may bias the plunger distally relative to the actuator, and be compressed when a proximally-directed force is applied to the plunger. The force reduction element may dissipate a portion of the proximally-directed force. Related devices and methods are also described.

Abstract: A method of rivet bonding a workpiece stack-up that includes one or more polymer composite workpieces, such as carbon fiber composite workpieces, involves several steps. In one step, adhesive is applied to a surface of the workpiece stack-up. In another step, workpieces—including the polymer composite workpiece(s)—are brought together. In yet another step the adhesive is partially or more cured. A rivet is installed through the workpiece stack-up and through the adhesive in another step. The method strengthens the resulting rivet-bonded joint by minimizing or altogether precluding fracture, cracking, and/or delamination thereat.

Abstract: A method of manufacturing a workpiece includes heating a pre-formed blank of a first fiber reinforced thermoplastic material in an oven. A second fiber reinforced thermoplastic material is heated in an extruder. The second fiber reinforced thermoplastic material is extruded from the extruder, within the oven, to form an extrudate. The extrudate is positioned on the pre-formed blank of the first fiber reinforced thermoplastic material, within the oven, to form a composite blank. The extrudate may be formed into a shape before being positioned onto the pre-formed blank, after being positioned onto the pre-formed blank. The composite blank may then be transferred to a final shaping station.

Abstract: A medical device includes a handle with a proximal arm and a distal arm. The proximal arm and the distal arm are pivotable via a joint. The medical device also includes a tube coupled to the distal arm and a drive wire. A distal portion of the drive wire includes an expandable end effector. A portion of the drive wire is positioned within the tube, and a different portion of the drive wire extends proximally of the distal arm and is coupled to the proximal arm.

Abstract: A method of rivet bonding a workpiece stack-up that includes one or more polymer composite workpieces, such as carbon fiber composite workpieces, involves several steps. In one step, adhesive is applied to a surface of the workpiece stack-up. In another step, workpieces—including the polymer composite workpiece(s)—are brought together. In yet another step the adhesive is partially or more cured. A rivet is installed through the workpiece stack-up and through the adhesive in another step. The method strengthens the resulting rivet-bonded joint by minimizing or altogether precluding fracture, cracking, and/or delamination thereat.

Abstract: Provided is a load-carrying or non-load carrying structural component for a vehicle having improved impact resistance, such as a gas tank protection shield, an underbody shield, a structural panel, an interior floor, a floor pan, a roof, an exterior surface, a storage area, a glove box, a console box, a trunk, a trunk floor, a truck bed, and combinations thereof. The component has a support structure with ridges, each spaced apart from one another at predetermined intervals, to form a corrugated surface capable of load-carrying. The ridges are longitudinally extending, raised ridges. The corrugated designs provide support structures that are impact resistant.

Abstract: A method of manufacturing a workpiece includes heating a pre-formed blank of a first fiber reinforced thermoplastic material in an oven. A second fiber reinforced thermoplastic material is heated in an extruder. The second fiber reinforced thermoplastic material is extruded from the extruder, within the oven, to form an extrudate. The extrudate is positioned on the pre-formed blank of the first fiber reinforced thermoplastic material, within the oven, to form a composite blank. The extrudate may be formed into a shape before being positioned onto the pre-formed blank, after being positioned onto the pre-formed blank. The composite blank may then be transferred to a final shaping station.

Abstract: Numerous devices are described. One device may comprise: a handle including a wire attachment portion; an actuator movably mounted to the handle, the actuator including a reaction chamber; a plunger movably mounted to the actuator, the plunger including a distal stop with a sheath attachment portion, and a proximal stop located in the reaction chamber; a resilient element including a distal end attached to the proximal stop, and a proximal end movable relative to plunger; and a force reduction element located in the reaction chamber between the resilient element and a reaction surface in the cavity. The resilient element may bias the plunger distally relative to the actuator, and be compressed when a proximally-directed force is applied to the plunger. The force reduction element may dissipate a portion of the proximally-directed force. Related devices and methods are also described.

Abstract: A vehicle structure comprising a body including a wheel house, a fender and an energy absorption member. The fender has an exposed A-side surface and an opposed B-side surface, with the fender including a laterally inner edge extending fore-and-aft that defines a portion of a hood opening, and the B-side surface adjacent to the laterally inner edge spaced from the wheel house in a vertical direction to define a crush gap. The energy absorption member is located in the crush gap between the wheel house and the fender, with the energy absorption member having a fender attachment flange secured to the B-side surface of the fender adjacent to the laterally inner edge, a body attachment flange secured to the wheel house, and an energy absorbing portion extending between the fender attachment flange and the body attachment flange, with the energy absorbing portion being curved in the vertical direction.

Abstract: Provided is a load-carrying or non-load carrying structural component for a vehicle having improved impact resistance, such as a gas tank protection shield, an underbody shield, a structural panel, an interior floor, a floor pan, a roof, an exterior surface, a storage area, a glove box, a console box, a trunk, a trunk floor, a truck bed, and combinations thereof. The component has a support structure with ridges, each spaced apart from one another at predetermined intervals, to form a corrugated surface capable of load-carrying. The ridges are longitudinally extending, raised ridges. The corrugated designs provide support structures that are impact resistant.

Abstract: Provided is a load-carrying or non-load carrying structural component for a vehicle having improved impact resistance, such as a gas tank protection shield, an underbody shield, a structural panel, an interior floor, a floor pan, a roof, an exterior surface, a storage area, a glove box, a console box, a trunk, a trunk floor, a truck bed, and combinations thereof. The component has a support structure with ridges, each spaced apart from one another at predetermined intervals, to form a corrugated surface capable of load-carrying. The ridges are longitudinally extending, raised ridges. The corrugated designs provide support structures that are impact resistant.

Abstract: A vent assembly is disposed within an interior space of a vehicle for opening and closing fluid communication between the interior space and an exterior of the vehicle. The vent assembly includes a housing defining a plurality of openings and a plurality of vanes disposed in the openings. An actuator mechanism moves the vanes between an open position and a closed position, and includes a shaped memory alloy (SMA) member for actuating the vanes between the open and closed positions. The SMA member is activated when a hatch of the vehicle is opened to move the vanes into the open position and thereby open fluid communication between the interior space and the exterior to alleviate excessive air pressure buildup during closure of the hatch.