Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A urine collection assembly includes a container; a funnel removably coupled to the container, the funnel in fluid communication with the container; a first collection chamber in selective communication with the funnel; a valve configured to allow selective communication between the first collection chamber and the funnel; a second collection chamber in selective communication with the funnel; and a lid removably coupleable to the funnel. A saddle may be removably coupleable to the funnel and configured to guide urine into the container.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.

Abstract: 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: The invention provides methods of optically detecting an analyte in a medium as the analyte moves with respect to a nanopore. The analyte may be, for example, a biological molecule such as a polynucleotide or polypeptide. Systems and apparatuses for carrying our such methods are also provided.

Abstract: A computing device receives user input for a design of an experiment. The user input indicates respective factor identities for factors in the design of the experiment, respective response identities for responses to options for the factors in the design, and a user-defined objective for the one or more responses. Additionally, based on the user input, the computing device displays a subset of a set of multiple model types and a user-definable amount of design runs for the design. Each design run presents settings according to the design for each of the factors. The computing device also receives settings indicating a user-selected model type from the subset and a user-defined amount of design runs, and based on the settings, selects one or more design construction criteria for generating the design. The computing device then generates the design according to the design construction criteria.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a radio unit (RU) may receive, from a user equipment (UE), a demodulation reference signal (DMRS) associated with a channel. The RU may perform a channel estimation associated with the channel using the DMRS to obtain channel estimation information. The RU may transmit, to a distributed unit (DU), information that is based at least in part on the channel estimation information. Numerous other aspects are described.

Abstract: A dialysis system comprising a dialysis machine (100) having a main body portion, a water purification system, the water purification system being separate to the dialysis machine, and a liquid sanitizer (200). The liquid sanitizer (200) is provided within the main body portion of the dialysis machine. The liquid sanitizer (200) is fluidly connected between the dialysis machine (100) and the water purification system. The liquid sanitizer (200) has a heater (240) arranged to heat a volume of liquid, a temperature sensor arranged to sense the temperature of the volume of liquid and a liquid sanitizer controller (250). The dialysis system defines a first closed fluid circuit comprising the dialysis machine and the liquid sanitizer and a second closed fluid circuit comprising the water purification system, the dialysis machine and the liquid sanitizer. The liquid sanitizer (200) is configured to effect sanitization of the first closed fluid circuit and the second closed fluid circuit.

Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.

Abstract: Providing cognitive responses with an electronic message system includes predicting an urgency level corresponding to an electronic message received by the system based on detecting pre-defined features within the message and assigning a classification to the message based on the detected features. The message and corresponding urgency level can be mapped to a response action based on the classification assigned to the message. A notification of the response action and corresponding urgency level can be generated.

Abstract: An apparatus includes a processor to: generate variants of an experiment design based on varied parameters; for each variant, estimate terms based on the model, and derive an optimality value; present a table of the variants including a column for each varied parameter and a column for the optimality value, a row for each variant, and a bar graph for each column depicting a distribution of the values therein; present function controls operable to select a function to perform on row(s) of the table in response to selection of a bar of a bar graph of a column; in response to selection of a function, change the current function to the selected function; and in response to a selection of a bar of a bar graph of a column, perform the current function on row(s) based on instances of the value associated with selected bar.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A pump and valve arrangement (201), a dialysis system (10) comprising the pump and valve arrangement 201 and a method of operating a pump and valve arrangement (201). The pump and valve arrangement (201) has a dialyser having a semi-permeable membrane. The pump and valve arrangement (201) delivers dialysis fluid to and from the dialyser (12). The pump and valve arrangement (201) has a control system (450) configured to shuttle dialysis fluid between an inlet pump assembly and the dialyser (12) one or more times so as to agitate the surface of the semi-permeable membrane of the dialyser (12).

Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: Indazole compounds for treating various diseases and pathologies are provided. More particularly, the use of an indazole compound or analogs thereof, in the treatment of inflammatory diseases or disorders is provided.

Abstract: A dialysis system (10) comprising a dialysis machine (20) and a water purification system (30). The water purification system (30) comprising a pre-treatment system (10) and a primary treatment system (80). The water purification system (30) is provided within a portable unit (90) defining an enclosure. The dialysis machine (20) is removably provided on an upper surface of the enclosure of the portable unit (90).

Abstract: An apparatus includes a processor to: present prompts guiding selection of first subset terms for estimation of variants of an experiment design based on a model thereof, and second subset terms for estimation using Bayesian modification; monitor for selections of term; in response to each change in the first subset terms, determine whether all first subset terms can be estimated based on the model; in response to the first subset including too many terms, present an indication of too many terms being selected for estimation based on the model; in response to the first subset including fewer terms than can be estimated based on the model, present an indication that more terms could be selected for estimation based on the model; and for each variant of the experiment design, estimate each first subset term based on the model, and estimate each second subset term using Bayesian modification.

Abstract: This disclosure provides systems, methods and apparatuses for protecting against transmit power violations in a radio unit (RU) of a disaggregated base station. For example, when a distributed unit (DU) provides frequency domain samples to the RU, the DU may set a reference input level that causes the RU scale a gain lineup to avoid saturation or sensitivity issues in a signal processing chain while ramping up to a required transmit power. Accordingly, to avoid signal saturation or clipping at the RU, the RU may monitor energy estimation measurements and take remedial action when a transmit power violation occurs. For example, the RU may provide one or more system alarms to the DU or prevent transmission over an air interface in cases where the energy estimation measurements fail to satisfy one or more thresholds.

Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.