Abstract: A Circadian Rhythm Monitoring and Regulation (CMR) system and method that includes: a novel non-obtrusive wearable system for increasing the health and productivity of warfighters or other individuals that are disrupted by excessive, abnormal shifts in work or flights across multiple time zones. The CMR system is based on advanced sensor and software technology and models of human circadian system phototransduction and a circadian stimulator oscillator developed by applicants. It measures circadian misalignment and provides lighting suggestions for circadian rhythm maintenance and realignment.

Abstract: Systems and methods are presented for efficient cross-fading of compressed domain information streams on a user/client device. Exemplary systems may provide cross-fade between AAC/Enhanced AAC Plus information streams, between MP3 information streams, or between information streams of unmatched formats. These systems are distinguished in that cross-fade is directly applied to compressed bitstreams so a single decode operation is performed on the resulting bitstream. Thus, a set of frames from each input stream associated with the time interval in which a cross fade is decoded, and combined and recoded with a cross fade or other effect now in the compressed bitstream. Once sent through the client device's decoder, the user hears the transitional effect. The only input data that is decoded and processed is that associated with the portion of each stream used the crossfade, blend or other interstitial, and thus the vast majority of input streams are left compressed.

Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(triflu-oromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl] [2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of car-diopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic tromboembolic pulmonary hyperten-sion (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pu

Abstract: A method including: monitoring a set of streaming metrics for a video stream during a set of time intervals of a first duration during a first time window; in response to a first streaming metric, executing an image classification model based on a set of image frames in the video stream to characterize the image frames according to a set of tags; retrieving a content manifest associated with a content type of the video stream, the content manifest defining a set of target concepts related to the content type; deriving a difference between the set of tags to the set of target concepts in the content manifest to compute a match score for the video stream; in response to the match score exceeding a threshold score, flagging the video stream for manual authentication; and in response to receiving an abuse confirmation from the operator removing the video stream from the streaming platform.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: A system and method for controlling flow of air into an air compressor of an air compressor system includes a proportional solenoid valve configured to control flow of supply air into the air compressor in proportional response to sensed air pressure generated by the air compressor system.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the myosin regulatory light chain interacting protein (MYLIP) gene, as well as methods of inhibiting expression of MYLIP, and methods of treating subjects that would benefit from reduction in expression of MYLIP, such as subjects having a MYLIP-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: A chemical synthesis plant comprising: one or more reactors configured for producing, from one or more reactants, a process stream comprising at least one chemical product; a feed preparation system configured to prepare one or more feed streams comprising one or more of the one or more reactants for introduction into the one or more reactors; and/or a product purification system configured to separate the at least one chemical product from reaction byproducts, unreacted reactants, or a combination thereof within the process stream, wherein the chemical synthesis plant is configured such that a majority of the net energy needed for heating, cooling, compressing, or a combination thereof utilized via the one or more reactors, the feed preparation system, the product purification system, or a combination thereof is provided from a non-carbon based energy source, from a renewable energy source, and/or from electricity.

Abstract: A system is provided. The system includes at least one computing device. The at least one computing device receives a recognized person message indicating a recognized person associated with a premises is proximate an access location of the premises, where the recognized person message corresponds to a first authentication indication for authenticating the recognized person. The at least one computing device further, in response to receiving the recognized person message, transmits a command to capture an audible passcode from the recognized person. The at least one computing device further receives a passcode message based on the audible passcode, authenticates the recognized person based on the recognized person message and the passcode message, and in response to authenticating the recognized person causes the premises monitoring system to disarm and causes an electronic door lock associated with the premises to unlock.

Abstract: A system comprising at least one computing device is provided. The at least one computing device is configured to monitor a chat environment associated with a plurality of users corresponding to a premises having a premises monitoring system, determine that a chat message in the chat environment invokes a chatbot associated with the premises monitoring system, and in response to determining that the chat message invokes the chatbot, determine that the chat message comprises an access command for the premises monitoring system. The at least one computing device is further configured to store access data based on the access command to facilitate the premises monitoring system implementing the access command.

Abstract: A system is provided. The system includes at least one computing device configured to receive first authentication data based on video of a person captured by a premises device located at a premises, receive second authentication data based on audio of the person speaking a verbal passcode captured by the premises device, and authenticate the person based on the first authentication data and the second authentication data. The at least one computing device is configured to determine that the person is permitted access to the premises according to an access policy, and in response to authenticating the person and determining that the person is permitted access to the premises, cause a lock securing an access point of the premises to unlock.

Abstract: This disclosure describes methods and systems to externally manage network-to-network interconnect configuration data in conjunction with a centralized database subsystem. An example of the methods includes receiving and storing, in the centralized database subsystem, data indicative of user intent to interconnect at least a first network and a second network. The example method further includes, based at least in part on the data indicative of user intent, determining and storing, in the centralized database subsystem, a network intent that corresponds to the user intent. The example method further includes providing data indicative of the network intent from the centralized database subsystem to a first data plane adaptor, associated with the first network, and a second data plane adaptor, associated with the second network.

Abstract: An olefin synthesis plant comprising: a feed pretreatment section configured to pretreat a feed stream; a pyrolysis section comprising one or more pyrolysis reactors configured to crack hydrocarbons in the feed stream in the presence of a diluent to produce a cracked gas stream; a primary fractionation and compression section configured to provide heat recovery from and quenching of the cracked gas stream; remove a component from the cracked gas stream; and compress the cracked gas stream, thus providing a compressed cracked gas stream; and/or a product separation section configured to separate a product olefin stream from the compressed cracked gas stream, wherein the olefin synthesis plant is configured such that, relative to a conventional olefin synthesis plant, more of the energy and/or the net energy required by the olefin synthesis plant and/or one or more sections thereof, is provided by a non-carbon based and/or renewable energy source and/or electricity.

Abstract: A chemical synthesis plant comprising: one or more reactors configured for producing, from one or more reactants, a process stream comprising at least one chemical product; a feed preparation system configured to prepare one or more feed streams comprising one or more of the one or more reactants for introduction into the one or more reactors; and/or a product purification system configured to separate the at least one chemical product from reaction byproducts, unreacted reactants, or a combination thereof within the process stream, wherein the chemical synthesis plant is configured such that a majority of the net energy needed for heating, cooling, compressing, or a combination thereof utilized via the one or more reactors, the feed preparation system, the product purification system, or a combination thereof is provided from a noncarbon based energy source, from a renewable energy source, and/or from electricity.

Abstract: A methanol synthesis plant comprising: a feed pretreating section operable to pretreat a feed stream; a synthesis gas (syngas) generation section comprising one or more reactors operable to produce a syngas synthesis product stream comprising synthesis gas from the feed stream; a methanol synthesis section comprising one or more methanol synthesis reactors operable to produce a synthesis product comprising methanol; and/or a methanol purification section operable to remove at least one component from the synthesis product to provide a purified methanol product; wherein the methanol synthesis plant is configured such that, relative to a conventional methanol synthesis plant, more of the net energy required by the methanol synthesis plant, the feed pretreating section, the syngas generation section, the methanol synthesis section, the methanol purification section, or a combination thereof, is provided by a non-carbon based energy source, a renewable energy source, and/or electricity.

Abstract: An olefin synthesis plant comprising: a feed pretreatment section configured to pretreat a feed stream; a pyrolysis section comprising one or more pyrolysis reactors configured to crack hydrocarbons in the feed stream in the presence of a diluent to produce a cracked gas stream; a primary fractionation and compression section configured to provide heat recovery from and quenching of the cracked gas stream; remove a component from the cracked gas stream; and compress the cracked gas stream, thus providing a compressed cracked gas stream; and/or a product separation section configured to separate a product olefin stream from the compressed cracked gas stream, wherein the olefin synthesis plant is configured such that, relative to a conventional olefin synthesis plant, more of the energy and/or the net energy required by the olefin synthesis plant and/or one or more sections thereof, is provided by a non-carbon based and/or renewable energy source and/or electricity.

Abstract: An electrically powered furnace and related methods may include an electrically powered furnace having an output of at least one megawatt with a control system; a furnace housing comprising one or more housing walls at least partially defining an interior volume; a plurality of heating zones within the interior volume; and a plurality of heated tubes extending in the interior volume. A method may include providing the feed to the electrically powered furnace; and algorithmically adjusting the output of the one or more heating elements for each of the plurality of heating zones to heat the feed to a desired temperature while maintaining temperatures of the one or more heating elements within predetermined parameters.

Abstract: A methanol synthesis plant comprising: a feed pretreating section operable to pretreat a feed stream; a synthesis gas (syngas) generation section comprising one or more reactors operable to produce a syngas synthesis product stream comprising synthesis gas from the feed stream; a methanol synthesis section comprising one or more methanol synthesis reactors operable to produce a synthesis product comprising methanol; and/or a methanol purification section operable to remove at least one component from the synthesis product to provide a purified methanol product; wherein the methanol synthesis plant is configured such that, relative to a conventional methanol synthesis plant, more of the net energy required by the methanol synthesis plant, the feed pretreating section, the syngas generation section, the methanol synthesis section, the methanol purification section, or a combination thereof, is provided by a non-carbon based energy source, a renewable energy source, and/or electricity.

Abstract: Delivery devices and methods for delivering a prosthetic heart valve. The delivery device includes an inner shaft assembly with a valve retainer, an outer shaft assembly, a handle assembly and an axial force adjustment assembly. The outer shaft assembly includes a capsule containing the prosthetic valve in a loaded state. The handle assembly is coupled to a proximal region of the outer shaft assembly. The axial force adjustment assembly connects a proximal section of the inner shaft assembly to the handle assembly, and is configured to selectively move the proximal section relative to the handle assembly. The axial force adjustment assembly can include an actuator member and a driver member. The driver member directly interfaces with the inner shaft assembly, and a force applied to the actuator member is transferred onto the proximal section via the driver member. A sensor for sensing tension and/or compression in the inner shaft assembly can be provided.

Abstract: A process for preparation of a biologically active polymer comprising an acrolein derived segment and a polyalkylene glycol oligomer, the process comprising reacting polyalkylene glycol with acrolein in aqueous solution to form a copolymer of molecular weight no more than 1000 Daltons at a temperature of no more than 15° C.