Abstract: The present disclosure generally relates to the expression of T2R taste receptors in eukaryotic cells, such as U2OS cells. The disclosure also relates to methods of expressing T2R taste receptors in such cells, and to methods of screening for substances that modulate T2R receptors, and which, therefore, may be useful as modulators of bitter taste.

Abstract: Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.

Abstract: Commercially available waterbased adhesives can be used to adequately secure unmodified TPO roofing membrane to a roof substrate only by using a two-sided (contact bond) application. Alternatively, commercially available waterbased adhesives may be used a single-sided application using TPO membrane that is modified at manufacture with an additional backing (“fleece back”). Disclosed herein is a water-based adhesive formulation that will bond unmodified TPO membrane to the roof with a one-sided application, saving money and increasing productivity. The disclosed adhesive is applicable by high pressure canister application, facilitating the efficiency of its use.

Abstract: The present disclosure relates to bonding a first substrate together a second substrate with adhesives that are substantially tackifier free. A layer of substantially tackifier free adhesive may be applied to a first surface of the second substrate to define an adherence zone, and the first substrate is positioned on the adherence zone of the second substrate to form a laminate. The first and second substrates are pressed against each other in the adherence zone to force the substantially tackifier free adhesive to penetrate into the first and second substrates. A first portion of the layer of the adhesive penetrates into the first substrate and a second portion of the layer of the adhesive penetrates into the second substrate. A central portion of the layer of the adhesive between the first and second portions separates the second surface of the first substrate from the first surface of the second substrate.

Abstract: A system for use in servicing a machine. The system includes a tubular body including a longitudinal axis, a tip end, a dispensing nozzle defined at the tip end, and an interior channel in flow communication with the dispensing nozzle. The tubular body is configured to be flexible. An actuator is configured to selectively modify an orientation of the tubular body, and a reservoir is in flow communication with the interior channel. The reservoir is configured to supply a maintenance fluid to the tubular body for discharge from the dispensing nozzle.

Abstract: A detergent product containing a detergent composition is provided.

Abstract: The present disclosure provides piperazine substituted fused azadecalin compounds of Formula J, I, Ia, Ib, Ib-1, Ib-2, Ic and Id for use in pharmaceutical formulations, and for modulating glucocorticoid receptors.

Abstract: Disclosed herein are formulations of imatinib or a phenylaminopyrimidine derivative compound for aerosolization and use of such formulations for inhaled aerosol administration of imatinib or a phenylaminopyrimidine derivative compound for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. In some embodiments, formulations and delivery options described herein allow for efficacious local delivery of imatinib or a phenylaminopyrimidine derivative compound or salt thereof. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that may benefit by reformulation and inhalation administration.

Abstract: The runtime retargeting approaches discussed herein can enable real time adaptation of character and object motion. In particular, fixed-source motion can be dynamically adjusted to variable situations encountered during runtime. In this way, the runtime retargeting approaches discussed herein can preserve the intent, visual quality, and essence of such fixed-source motion, while modifying it to meet new physical constraints or goals.

Abstract: An overcurrent protection system for a mobile irrigation system. The overcurrent protection system includes a number of control panels each including a controller configured to generate a motor control signal for activating one of the motors of the mobile irrigation system, transmit the motor control signal to the motor, determine a current magnitude of electrical current passing through a motor power branch line electrically connected to the motor, and restrict current to the motor if the current magnitude is above a current magnitude threshold. The controller is further configured to set the current magnitude threshold according to one of a plurality of motor operation stages. The current magnitude threshold can also be set remotely.

Abstract: An adaptive support garment integrating directional fabrics to assist in providing adaptive support to select portions of the garment is discussed herein. The adaptive support garment can include a first directional fabric, a second directional fabric, and a tension device. The first directional fabric includes first directional fibers, and the first directional fabric can be coupled to a fixed portion of the adaptive support garment. The second directional fabric includes second directional fibers, and the second directional fabric can be coupled to a movable control structure portion of the adaptive support garment. The tension device can be coupled to the movable control structure and configured to apply a tension in a first direction on the movable control structure. In operation, the first directional fibers can engage with the second directional fibers to resist movement in a second direction opposite the first direction.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: A system and method of an in-place content management system that allows an organization to bring the power of an enterprise content management (ECM) system (supporting such features as check-out, check-in, security, audit, add, rename, move, delete, classification, legal holds and disposition) to the data where it resides on an NTFS file system, eliminating the need to move it somewhere else and without having to change the way end-users work. A utility or tool for content management that leverages the existing security that is already in place on files and folders and adds basic content management features such as check-out/check-in (preventing multiple users from editing the same document at the same time), audit history, and the ability to add classifications, trigger dispositions, and apply legal holds on documents where they currently reside.

Abstract: A microspeaker includes a frame defining a space; and an actuator positioned within the space, the actuator including a diaphragm configured to vibrate in a first direction during operation. A center axis of the diaphragm extends in the first direction. A plate assembly mechanically couples to the frame and defines a path for venting fluid from the space. The plate assembly includes: a first plate extending in a plane and defining first apertures that are offset from the center axis in the plane; and a second plate defining a second aperture intersected by the center axis. The second plate includes: an inner recessed region abutting the second aperture; and an outer non-recessed region. The first plate is mechanically coupled to the second plate, the first plate and the inner region of the second plate defining a channel that fluidly couples the first apertures to the second aperture.

Abstract: A topographical inspection device that employs one or both of a photometric stereo system for determining surface normal for individual pixel locations in an image space and/or dot pattern projection. A device body supports light elements at spaced apart locations to illuminate an inspection region and a dot pattern projector for projecting a dot pattern onto the inspection region. A camera captures images of the surface when illuminated by the light elements and/or dot pattern projector. Controlling the light elements and camera, a first topographical measurement of the inspection region is made based on light intensity in images taken by the camera. A second topographical measurement may be made based on dot pattern projection.

Abstract: The disclosures herein relate to novel compounds of formula (1) and salts thereof, wherein V; W; X; Y; Z; R1; R2; R3; R4 and R5 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

Abstract: An example virtualized computing system includes: a host cluster having hosts and a virtualization layer executing on hardware platforms of the hosts, the virtualization layer supporting execution of virtual machines (VMs); an orchestration control plane integrated with the virtualization layer, the orchestration control plane including a master server executing in a first VM of the VMs; guest cluster infrastructure software (GCIS) executing in the master server, the GCIS configured to create a set of objects defining a container orchestration cluster, and manage lifecycles of second VMs of the VMs based on state of the set of objects; and guest software executing in the second VMs to implement the container orchestration cluster as a guest cluster of the host cluster, the guest software having components that interface with the GCIS.

Abstract: A system and a method for locating and visualizing camera images in relation to a large-scale manufacturing product with repetitive structures are disclosed. The system includes a trackable camera device, a tracking subsystem, and an image overlay module. The trackable camera device can capture images of surface features of the large-scale product. The tracking subsystem is configured to generate a tracking record that contains the position and location of the trackable camera device over time. The image overlay module is configured to precisely overlay the captured images on a three-dimensional model of the large-scale product based on where the trackable camera device was tracked when each image was captured. A method is disclosed for using the components of the system to overlay the captured images, and a method of auditing the large-scale product by comparing a region of interest to previously captured images overlaid on a respective three-dimensional model.

Abstract: A portable cooler container with active temperature control includes a double-walled insulated container body with a chamber to receive and hold temperature sensitive products. A control system is at least partially disposed between an outer wall and an inner wall of the container body. An electronic display screen on one of the lid and the container body configured to display shipping address information for the portable cooler container.

Abstract: A central processor for controlling a shut down of operations of an irrigation system after a problem is detected comprises a processing element configured to: monitor an operation of the irrigation system; determine a problem has occurred requiring a shut down of the operation of the irrigation system; and apply an algorithm to determine a timing of when to shut down the operation of the irrigation system.