Abstract: The present disclosure provides compounds of Formula I, Ia, Ib, Ib-1, Ib-2, Ic, Ic-1, Id-1, and Id-2. Compounds of Formula I, Ia, Ib, Ib-1, Ib-2, Ic, Ic-1, Id-1, and Id-2 may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: Technology is disclosed herein for content assistance processes via foundation model integrations in software applications. In an implementation, a computing device receives natural language input from a user relating to content of a document in a user interface of an application. The computing device generates a first prompt for a foundation model to generate at least a completion to the natural language input. The computing device receives a reply to the first prompt from the foundation model which includes a completion to the natural language input. The computing device causes display of the completion in association with the natural language input in the user interface and receives user input comprising an indication to combine the input and the completion, resulting in a revised natural language input. The computing device submits a second prompt including the revised natural language input to the foundation model.

Abstract: Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.

Abstract: A heat extraction system for extracting heat from a reservoir, the system including a co-axial tool configured to be placed underground, the co-axial tool having an outer pipe and an inner pipe located within the outer pipe, each of the outer pipe and the inner pipe being connected to a shoe so that a fluid flows through an annulus defined by the inner and outer pipes, reaches the shoe, and flows through a bore of the inner pipe; and a power generator fluidly connected to a chemical processing unit to receive a fluid, and also fluidly connected with a first port to the inner pipe and with a second port to the outer pipe of the co-axial tool. A temperature difference of the fluid at the power generator and at the co-axial tool drives the power generator to generate energy.

Abstract: An aircraft lavatory is disclosed herein. The aircraft lavatory includes a standard access door providing access to the aircraft lavatory from at least one of an aisle, a cross aisle, or a passageway of an aircraft, a first moveable wall adjacent the standard access door, the first moveable wall having a first end and a second end and configured to move between a closed position and an open position, the first end of the first moveable wall configured to rotate about a first pivot point, and a second moveable wall adjacent the first moveable wall, the second movable wall having a first end and a second end and configured to move between a closed position and an open position, the first end of the second moveable wall configured to rotate about a second pivot point.

Abstract: A display rack for bicycles provides opposed wheel cups for engaging the periphery of a bicycle wheel where one wheel cup is mounted to a pivoting lever that is pressed downward on one end by the weight of the bicycle tire to move the wheel cups together providing a gravity actuated clamping that is released when the bicycle is lifted. One or more wheel cups may extend in a channel measured in a tangent to the bicycle wheel to prevent locking to knob bicycle tires.

Abstract: Systems, methods, devices, and models for range estimation and analysis in battery powered vehicles are described. Energy consumption over vehicle trips is collected, to evaluate weighting factors for a weighted sum. The weighted sum is evaluated based on determined weighting factors and expected trip data, to determine an energy consumption of a trip or trips of a vehicle. Determined energy consumption for trips is used for evaluating suitability of the vehicle for performing the trips.

Abstract: A work machine, such as an excavator or a backhoe, has a linkage of articulating arms for maneuvering a changeable work tool. Position and motion sensors and force sensors within the linkage provide data for a controller to determine a location of the work tool and down force applied from the linkage onto the work tool during a job. Based on characteristics of the work tool, an acceptable range of down force applied by the linkage may be assigned. If down force reaches an outer bound of the acceptable range during the job, the controller may generate an alert for the operator or adjust action by the work tool to maintain the down force within the acceptable range. Depending on the work tool and job, the down-force control can help improve work quality and guard against tool damage from dry-fire or overload conditions.

Abstract: A work machine, such as an excavator or a backhoe, has a linkage of articulating arms for maneuvering a changeable work tool. Position and motion sensors and force sensors within the linkage provide data for a controller to determine a location of the work tool and down force applied from the linkage onto the work tool during a job. Before performing a grading operation, an operator may request level control for the work tool at a benchmark orientation and down-force control at a target down force. After a controller applies the target down force with the work tool at the benchmark orientation, an operator may traverse the work tool along a path radial to the work machine. While maintaining the benchmark orientation for the work tool, the controller may adjust one or more forces on the linkage to also maintain the target down force during the traversal of the work tool, leading to simpler functionality for the operator and higher quality work product.

Abstract: System and computer-implemented method for updating applications running in a distributed computing system uses an update agent associated with an existing application to make a request for update information regarding the existing application to a service to receive a response that includes a target version of the existing application and an update window of time, which is based on information contained in the request for update information. A deployment of the target version of the existing application within the update window of time is coordinated by the update agent when the target version is newer than a current version of the existing application.

Abstract: A fault detection system for detecting an electrical fault in a component includes an optical conductor with a first end and a second end, and configured to optically face the component. A first sensor and a second sensor can be operably coupled to the first end and the second end, respectively. The first sensor and the second sensor are each configured to detect electromagnetic radiation propagating through the optical conductor.

Abstract: An integrated technology platform includes multiple hardware and software components that enable any application of autonomous agricultural equipment operation in an agricultural or other off-road setting, within a common software structural architecture. The integrated technology platform represents a technology stack that is a modular architecture that can be leveraged across multiple use cases and vehicle types. The integrated technology platform includes a vehicle interface component responsible for the physical interface to agricultural equipment, a telematics component that enables stable in-field communications between all aspects of the integrated technology platform, and a perception component that operates as a safety mechanism and includes object detection and classification. Additionally, a cloud-side application performs account management and field setup and as well as syncing of field equipment and operating systems in a common operating system.

Abstract: An RF pulse correlator comprising a track database, an antenna, a receiver, and a processor. The track database is configured to store established tracks of RF emissions. The antenna and receiver are configured to receive RF pulses. The tracker is configured to generate improved geolocation data for every received RF pulse based on kinematics of the received RF pulses. The processor is communicatively coupled to the database, the receiver, and the tracker. The processor is configured to associate each received RF pulse with an existing track in the track database or to create a new track.

Abstract: A geothermal plant, for extracting energy from a geothermal reservoir located below the ocean bottom, includes a floating platform; a riser that extends from a well drilled into the geothermal reservoir, to the floating platform; an electrical pump having a mechanical actuation part located in a bore of the riser, and an electronic part located outside the riser, wherein the electrical pump is configured to pump a geothermal liquid from the geothermal reservoir to the floating platform; and a power plant located on the floating platform and configured to use a steam produced by the geothermal liquid to generate electrical power. The electrical pump is placed at a depth of the riser where the geothermal liquid is in a single-phase.

Abstract: Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.

Abstract: The present disclosure relates to bonding a first substrate together a second substrate with adhesives that are substantially tackifier free. A layer of substantially tackifier free adhesive may be applied to a first surface of the second substrate to define an adherence zone, and the first substrate is positioned on the adherence zone of the second substrate to form a laminate. The first and second substrates are pressed against each other in the adherence zone to force the substantially tackifier free adhesive to penetrate into the first and second substrates. A first portion of the layer of the adhesive penetrates into the first substrate and a second portion of the layer of the adhesive penetrates into the second substrate. A central portion of the layer of the adhesive between the first and second portions separates the second surface of the first substrate from the first surface of the second substrate.

Abstract: The present disclosure generally relates to the expression of T2R taste receptors in eukaryotic cells, such as U2OS cells. The disclosure also relates to methods of expressing T2R taste receptors in such cells, and to methods of screening for substances that modulate T2R receptors, and which, therefore, may be useful as modulators of bitter taste.

Abstract: Commercially available waterbased adhesives can be used to adequately secure unmodified TPO roofing membrane to a roof substrate only by using a two-sided (contact bond) application. Alternatively, commercially available waterbased adhesives may be used a single-sided application using TPO membrane that is modified at manufacture with an additional backing (“fleece back”). Disclosed herein is a water-based adhesive formulation that will bond unmodified TPO membrane to the roof with a one-sided application, saving money and increasing productivity. The disclosed adhesive is applicable by high pressure canister application, facilitating the efficiency of its use.

Abstract: A system for use in servicing a machine. The system includes a tubular body including a longitudinal axis, a tip end, a dispensing nozzle defined at the tip end, and an interior channel in flow communication with the dispensing nozzle. The tubular body is configured to be flexible. An actuator is configured to selectively modify an orientation of the tubular body, and a reservoir is in flow communication with the interior channel. The reservoir is configured to supply a maintenance fluid to the tubular body for discharge from the dispensing nozzle.

Abstract: A detergent product containing a detergent composition is provided.