Abstract: A variable tether system adapted for use in an inflatable cushion of an airbag module having a first pair of tether elements each having a first end and a second end, the first ends each being secured to inner portions of the inflatable cushion and the second ends each being secured to inner portions of the inflatable cushion, the first ends each being secured to the inflatable cushion at positions remote from the second ends and the second ends being secured to the inflatable cushion at a location closer to an inflation opening of the inflatable cushion than the first ends, wherein each of the first pair of tether elements has a portion between each of the first and second ends which is not secured to the inflatable cushion; and a second pair of tether elements each having a first side and a second side, the first side of one of said second pair of tether elements being secured to a portion of one of the first pair of tether elements and the first side of the other one of the second pair of tether elements b

Abstract: This invention relates to a polyolefin copolymer composition produced with a catalyst having a metallocene complex in a single reactor in a process for the polymerization of an &agr;olefin monomer with one or more olefin comonomers, and a molecular weight maximum which occurs in that 50 percent by weight of the composition which has the highest weight percent comonomer content. Preferably, the composition has a comonomer partitioning factor C pf which is equal to or greater than 1.10 or molecular weight partitioning factor M pf which is equal to or greater than 1.15. Preferred composition also have at least 0.01 long chain branches per 1000 carbon atoms along the polymer backbone. These compositions with reverse molecular engineering have superior properties and are easily processable due to the simultaneous presence of the association of high molecular weight with high comonomer content and of long chain branching.

Abstract: The invention relates to a polyolefin copolymer composition produced with a catalyst having a metallocene, complex in a single reactor for the polymer of an &agr;-olefin monomer with one or more olefin comonomers, and a molecule weight maximum which occurs in that 50 percent by weight of the composition which has the highest weight percent comonomer content. Preferably, the composition has a comonomer partitioning fact Cpf which is equal to or greater than 1.10 or molecule weight partitioning fact Mpf which is equal to or greater than 1.15. Preferred composition also have at least 0.01 long chain branches per 1000 carbon atoms along the polymer backbone. These compositions with reverse molecular engineering have. superior properties and are easily processable due to the simultaneous presence of the association of high molecular weight with high comonomer content and of long chain branching.

Abstract: The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.

Abstract: The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.

Abstract: 5-Deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acid derivatives are provided as agents useful for treating susceptible neoplasms in mammals. Pharmaceutical formulations and intermediates are also provided.

Abstract: 5-Deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acid derivatives are provided as agents useful for treating susceptible neoplasms in mammals. Pharmaceutical formulations and intermediates are also provided.

Abstract: Granulocyte-colony stimulating factor (G-CSF) can be delivered systemically in therapeutically or prophylactically effective amounts by pulmonary administration using a variety of pulmonary delivery devices, including nebulizers, metered dose inhalers and powder inhalers. Aerosol administration in accordance with this invention results in significant elevation of the neutrophil levels that compares favorably with delivery by subcutaneous injection. G-CSF can be administered in this manner to medically treat neutropenia, as well as to combat or prevent infections.

Abstract: 4-Deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acid derivatives are provided as agents useful for treatment susceptible neoplasms in mammals. Pharmaceutical formulations and intermediates are also provided.

Abstract: A method for detecting organisms such as fungi and yeast in a sample attached to a solid phase, by detecting the presence of chitin in using lectin or anti-chitin antibodies.

Abstract: This invention provides certain isoxazole and isothiazole derivatives, their pharmaceutical formulations, and their use in inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.