Abstract: The invention relates to compounds of the following formula: and their pharmaceutically acceptable salts, pharmaceutical compositions containing this compounds, and methods of using this compound for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

Abstract: The invention relates to compounds of the following formula: and their pharmaceutically acceptable salts, pharmaceutical compositions containing this compounds, and methods of using this compound for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

Abstract: A decompression panel for use in a door of an aircraft disclosed herein includes bi-directional latching mechanisms. A differential pressure sensor disengages upon a decompression event in a compartment of an aircraft, allowing latch hooks to disengage from a panel latch of the decompression panel. Once disengaged, the decompression panel can rotate to vent air in a compartment of higher pressure to the compartment experiencing the decompression event.

Abstract: The compounds of the present invention are represented by the following formula (I): wherein the substituents R1, R2, R3, R4, (R5)m, R6, A, X, and Y are as defined herein. The compounds are useful in methods of treating a disorder which is created by or is dependent upon inhibiting GlyT-1.

Abstract: The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).

Abstract: A system for securing a truck bed cover includes a pair of vertical side rails clamped to the bed railing of a pickup truck. A first one of a pair of horizontal side rails is attached along the front side of the truck bed and the second one of the pair of horizontal side rails is attachable via a latching mechanism along the rear. The cover is attached along respective front and rear edges to each of the horizontal side rails, and is attachable along respective side edges to the vertical side rails, preferably, using a hook-and-loop fastener. Tensioning devices are employed to keep the cover taut and even on both sides.

Abstract: A system for securing a truck bed cover includes a pair of vertical side rails clamped to the bed railing of a pickup truck. A first one of a pair of horizontal side rails is attached along the front side of the truck bed and the second one of the pair of horizontal side rails is attachable via a latching mechanism along the rear. The cover is attached along respective front and rear edges to each of the horizontal side rails, and is attachable along respective side edges to the vertical side rails, preferably, using a hook-and-loop fastener. Tensioning devices are employed to keep the cover taut and even on both sides.

Abstract: The compounds of the present invention are represented by the following formula (I): wherein the substituents R1, R2, R3, R4, (R5)m, R6, A, X, and Y are as defined herein. The compounds are useful in methods of treating a disorder which is created by or is dependent upon inhibiting GlyT-1.

Abstract: The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.

Abstract: The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).

Abstract: A compound represented by the formula wherein R1, R2, R3 and R6 are the same or different and each is a hydrogen atom or a substituent; one of R4 and R5 is a hydrogen atom and the other is a group represented by the formula: —C(?X)—R7 wherein X is N—O—R8 or N—NH—R9 wherein R8 and R9 are the same or different and each is a hydrogen atom or a group bonded via a carbon atom; and R7 is a hydrogen atom or a substituent, and the like and a salt thereof have a superior I?B kinase inhibitory activity, and useful as pharmaceutical agents such as agents for preventing or treating diabetes and the like.

Abstract: The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed.

Abstract: The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.

Abstract: A compound represented by the formula wherein R1, R2, R3 and R6 are the same or different and each is a hydrogen atom or a substituent; one of R4 and R5 is a hydrogen atom and the other is a group represented by the formula: —C(?X)—R7 wherein X is N—O—R8 or N—NH—R9 wherein R8 and R9 are the same or different and each is a hydrogen atom or a group bonded via a carbon atom; and R7 is a hydrogen atom or a substituent, and the like and a salt thereof have a superior I?B kinase inhibitory activity, and useful as pharmaceutical agents such as agents for preventing or treating diabetes and the like.