Patents by Inventor Mark A. Wuonola

Mark A. Wuonola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6239291
    Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: May 29, 2001
    Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston University
    Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
  • Patent number: 6228882
    Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: May 8, 2001
    Assignees: Anadys Pharmaceuticals, Inc., Scriptgen Pharmaceuticals, Inc.
    Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
  • Patent number: 6184393
    Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: February 6, 2001
    Assignees: Trustees of Boston University, Scriptgen Pharmaceuticals, Inc.
    Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
  • Patent number: 6140361
    Abstract: 2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: October 31, 2000
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: Gary R. Gustafson, David G. Powers, Mark A. Wuonola
  • Patent number: 6127551
    Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: October 3, 2000
    Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston University
    Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
  • Patent number: 6090953
    Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: July 18, 2000
    Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston University
    Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
  • Patent number: 6022983
    Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
    Type: Grant
    Filed: January 2, 1998
    Date of Patent: February 8, 2000
    Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston University
    Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tao Hu, Jennifer V. Schaus
  • Patent number: 6020488
    Abstract: Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by 2,5-Bis[3-(2-N,N-dimethylaminopropylamidino)phenyl]furan.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: February 1, 2000
    Assignee: Scriptgen Pharmaceuticals Inc.
    Inventors: Mark A. Wuonola, Zhe Li
  • Patent number: 5986111
    Abstract: The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: November 16, 1999
    Assignees: Scriptgen Pharmaceuticals, Inc., Trustees of Boston University
    Inventors: Mark A. Wuonola, Gary R. Gustafson, James S. Panek, Tau Hu, Jennifer V. Schaus
  • Patent number: 5942547
    Abstract: This invention provides a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.3 independently are hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, --A--Ar--(Q).sub.z, etc.; wherein D is a C.sub.1-6 linear, C.sub.3-8 branched or cyclic group having from 4 to about 15 atoms, consisting of C, etc.; wherein D is unsubstituted or substituted with one or more groups independently selected from the group consisting of --OH, NH.sub.2, --NHR.sub.7, etc.; wherein each Q is independently --CNH(NHY), --NHCNH(NHY), --SO.sub.2 W, --SOW, etc.; wherein Y is hydrogen, alkyl, alkenyl, --B--NH.sub.2, --B--NHR.sup.8, etc.; wherein W is alkyl, alkenyl, --B--NH.sub.2, etc.; wherein A nd B independently are a bond, or a C.sub.1-6 linear, C.sub.3-8 branched or cyclic linking group having from 1 to about 15 atoms, consisting of C, optionally interrupted by N, S, P and O; wherein A and B independently are unsubstituted or substituted with --OH, NH.sub.2, etc.; wherein R.sup.7 is an alkyl, a branched alkyl, etc.; wherein R.sup.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: August 24, 1999
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: Gary R. Gustafson, David G. Powers, Mark A. Wuonola
  • Patent number: 5668165
    Abstract: Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by 2,5-Bis[3-(2-N,N-dimethylaminopropylamidino)phenyl]furan.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 16, 1997
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: Mark A. Wuonola, Zhe Li
  • Patent number: 5039690
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-oxa or thio-lH-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: August 13, 1991
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 5036092
    Abstract: Aminomethyl oxooxazolidinyl aza cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-3-aza-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 30, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 5036093
    Abstract: Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-3-aza-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 30, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 5032605
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-oxa or thia-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 16, 1991
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 4985429
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: January 15, 1991
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 4965268
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: October 23, 1990
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 4921869
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: May 1, 1990
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 4801600
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: October 9, 1987
    Date of Patent: January 31, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Patent number: 4022777
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkali metal, alkyl, substituted alkyl, alkylsulfenyl or acyl; R.sub.2 is alkyl or cyclopropyl; R.sub.3 is hydrogen, chlorine, bromine or fluorine; n and p are 0 or 1 and A is a mineral acid are useful as fungicides. A representative compound is 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline.
    Type: Grant
    Filed: September 22, 1975
    Date of Patent: May 10, 1977
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Donnie Joe Sam, Mark A. Wuonola