Abstract: The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.

Abstract: Data related to the adherence of a patient to a therapy regime can be collected from multiple medical devices, each of which may have an incomplete data set with data entries associated with times. Each incomplete data set represents a portion of a complete data set. The data sets can be integrated to create a complete data set with data entries from each incomplete data set being arranged in a temporal sequence with respect to one another. A report may be generated, the report having the data entries of the complete data set or a function of the data entries of the complete data set.

Abstract: The present disclosure provides methods, systems, and non-transitory computer-readable media for collecting, storing, assessing, and managing human readable diagnostic test results (e.g., results from Point-of-Care testing and self-testing). The present disclosure provides methods, systems, and non-transitory computer-readable media for collecting, storing, assessing, and managing images and image results. The systems and methods facilitate unbiased verification and notification of test and image results.

Abstract: A data processing system for machine-learning driven data analysis implements obtaining digital healthcare service provider information associated with one or more digital healthcare service providers and query parameters information from a user searching for digital healthcare service providers that may provide digital healthcare services to employees of the user. The system analyzes query parameter information using a first machine learning model to obtain category information. The system analyzes the category information and the digital health service provider information to predict digital healthcare service providers that provide services that the user may be interested in provided to the employees. These predictions are provided to the user as digital healthcare service recommendations.

Abstract: A distal aortic stent graft assembly including a main body having a proximal end and a distal end. The main body defines a peripheral opening. The proximal end defines a proximal opening. The distal end defines a distal opening. The proximal opening and the distal opening are configured to perfuse blood through the main body when the main body is in a deployed state. The distal aortic stent graft assembly further includes a coupling extending radially from the main body and corresponding to the opening in the main body. The coupling is configured to align with a blood vessel and perfuse blood through the coupling when the coupling is in the deployed state.

Abstract: The present disclosure relates to processes, methods, systems, and apparatus for steam cracking hydrocarbon in a pyrolysis furnace having a convection zone and a radiant zone. The convection zone includes three heat exchangers in series with a serpentine arrangement. A fluid source is disposed each heat exchanger to provide steam into the heat exchangers. The present disclosure further relates to a process of adjusting the stream flow rate for each fluid source to control operating conditions such as flue gas temperature, stack temperatures, and temperatures of other components of the furnace.

Abstract: Systems and methods are provided for configuring automatic playback settings on a media playback device. A graphical user interface displays automatic playback settings and receives selections of customized settings for automatic playback. The settings can include context granularity for automatic playback, limiting autoplay to when the media playback device is connected to a wireless network, and activating an audible notification when automatic playback of media content is beginning. An initial queue of media content is selected for playback on the media playback device. The system ascertains whether autoplay is enabled for a particular situation. If autoplay is enabled, the system automatically generates a queue of media that is related to the initial queue and initiates playback on the media playback device after the initial queue concludes.

Abstract: Embodiments of the instant disclosure relate to novel compositions, combination compositions, methods, and systems for generating and using hydrogels. In certain embodiments, the present disclosure provides for compositions including a polymer backbone having at least one hyaluronic acid backbone functionalized with an aliphatic aldehyde and at least one hyaluronic acid backbone functionalized with a hydrazide and a second polymer backbone including at least one 8-arm poly(ethylene glycol) (PEG). In certain embodiments, the present disclosure provides methods of treating a condition in a subject including administering hydrogels to the subject in the absence or presence of one or more therapeutic agent or cell.

Abstract: The embodiments described herein involve electrochemical cells that have a heating element integrated into the electrochemical cell. In some aspects, an electrochemical cell comprises an anode current collector, an anode material disposed on the anode current collector, a cathode current collector, a cathode material disposed on a first side of the cathode current collector, a separator disposed between the anode material and the cathode material, and a heating element disposed on a second side of the cathode current collector, the second side opposite the first side. The heating element may include an electrically conductive material and a conductive material and disposed in an insulative material.

Abstract: Embodiments described herein relate to electrochemical cells and multicells. A multicell can include a cell packaging that includes two or more electrochemical cells connected in series internal to the cell packaging. In some aspects, an apparatus includes a plurality of electrochemical cell stacks each including a plurality of electrochemical cells connected in series, a first electrically conductive plate including a first section and a second section, and a second electrically conductive plate. The first section of the first electrically conductive plate is in contact with a first terminal end of a first electrochemical cell stack from the plurality of electrochemical cell stacks. The second section of the first electrically conductive plate is in contact with a first terminal end of a second electrochemical cell stack from the plurality of electrochemical cell stacks.

Abstract: In some aspects, a method of monitoring health of an electrochemical cell can include measuring a first anode voltage at a first anode tab from the plurality of anode tabs and a second anode voltage at a second anode tab from the plurality of anode tabs; measuring a first cathode voltage at a first cathode tab from the plurality of cathode tabs and a second cathode voltage at a second cathode tab from the plurality of cathode tabs; and calculating a first sense voltage, the first sense voltage being a difference between the first cathode voltage and the first anode voltage. In some embodiments, a second sense voltage can be calculated, the second sense voltage being a difference between the second cathode voltage and the second anode voltage. In some embodiments, a difference between the first sense voltage and the second sense voltage can be calculated.

Abstract: A method of deploying a modular multibranch stent assembly. The method includes deploying a first modular stent device in an ascending aorta. The first modular stent device includes a main body, a bypass gate extending from the main body, and a bifurcated contra limb extending from the main body. The bifurcated contra limb includes a first distal limb and a second distal limb. The method further includes deploying a first bridging stent graft in the first distal limb and/or a second bridging stent graft in the second distal limb.

Abstract: Autonomous vehicles with global positioning systems are used for field inspection. A vehicle may be programmed to traverse a field, while using sensors to detect objects in the field, and then capture low-resolution images of the objects. Machine vision techniques are used with the low-resolution images to recognize the objects as crops, non-crop plant material or undefined objects. Location data is used to correlate recognized objects with digitally stored field maps to resolve whether a particular object is in a location at which crop planting is expected or not expected. Depending on whether an object in a low-resolution digital image is recognized as a crop, and whether the object is in an expected geo-location for crops, the vehicle may switch to a second image capture mode, for example, capturing a high-resolution image of the object, and/or execute a disease analysis and/or weed analysis on the images of the objects.

Abstract: A stent graft assembly including a main body and a branch coupling extending radially from the main body. A proximal end of the single branch stent device is configured to seal in an ascending portion of an aorta. The assembly further includes a modular stent device including a proximal end and a distal end. The proximal end of the modular stent graft is configured to couple to a distal end of the single branch stent device. The modular stent device includes a main body configured to couple inside the main body of the single branch stent device. The modular stent device includes a bypass gate and an artery leg. The modular stent device is configured to bifurcate at a bifurcation point from the main body to the bypass gate and the artery leg outside of and distal the distal end of the single branch stent device.

Abstract: The techniques of this disclosure generally relate to a modular stent device that is deployed into the ascending aorta via femoral access. The modular stent device is a base or anchor component to which additional modular stent devices can be attached to exclude diseased areas of the aorta while at the same time allowing perfusion of the brachiocephalic artery, the left common carotid artery, and/or the left subclavian artery.

Abstract: The techniques of this disclosure generally relate to a modular stent device including a main body configured to be deployed in the ascending aorta, a bypass gate configured to be deployed in the aorta, and a bifurcated contra limb. The bifurcated contra limb includes a single proximal limb that is bifurcated (split) into a first distal limb and a second distal limb. By forming the bifurcated contra limb to include a single proximal limb that is bifurcated into the distal limbs, guiding a guide wire into the relatively larger opening of bifurcated contra limb at a proximal end is simpler than guiding a guidewire into two smaller limbs extending distally from main body. Accordingly, cannulation of the bifurcated contra limb is relatively simple thus simplifying the procedure. In addition, the parallel design mimics anatomical blood vessel bifurcations to limit flow disruptions.

Abstract: The techniques of this disclosure generally relate to an assembly including a single branch stent device and a modular stent device configured to be coupled to the single branch stent device. The single branch stent device includes a main body and a branch coupling extending radially from the main body. The modular stent device includes a main body configured to be coupled inside of the main body of the single branch stent device, a bypass gate extending distally from a distal end of the main body of the modular stent device, and an artery leg extending distally from the distal end of the main body of the modular stent device.

Abstract: In an embodiment, autonomous vehicles with global positioning systems (GPS) are used for field inspection to reduce fuel and labor costs and improve reliability with increased consistency in field crop inspection. A vehicle may be programmed to traverse a field while using sensors to detect objects and operating in a first image capture mode, for example, capturing low-resolution images of objects in the field, typically crops. Under program control, machine vision techniques are used with the low-resolution images to recognize crops, non-crop plant material or undefined objects. Under program control, location data is used to correlate recognized objects with digitally stored field maps to resolve whether a particular object is in a location at which crop planting is expected or not expected.

Abstract: A method for deploying a stent device having a main body, a proximal coupling, and a distal coupling. The method includes extending a first guidewire in an aorta, extending a second guidewire in a brachiocephalic artery, and extending a third guidewire in an aortic branch vessel. The method further includes tracking the stent device along the first, second, and third guidewires. During the tracking step, the first guidewire extends through the main body, the second guidewire extends through the proximal coupling, and the third guidewire extends through the distal coupling. The method also includes deploying the main body within the aorta with the proximal coupling aligning with the brachiocephalic artery and the distal coupling aligning with the aortic branch vessel.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for display dynamic splash screens using a media device during a launch sequence of an application without interrupting or delaying processing of the launch sequence. A launch sequence may be considered to include operations for compiling code associated with the application and operations for displaying splash screens. An example embodiment operates by the media device launching the application responsive to receiving a request and while code for the application is being compiled, selecting and displaying a dynamic splash screen. Operations of compiling code and displaying the splash screen may be performed under the control of the media device operating system and control is passed from the operating system to the application after launch sequence is completed.