Abstract: The present disclosure provides metalloporphyrin and metallochlorin compounds (e.g., compounds of Formula (II) and (III)), which are useful in the preparation of optical devices (e.g., contact lenses, intraocular lenses, implantable contact lenses) that protect retinal pigment epithelium by the selective blocking of blue light. Also provided are precursor porphyrin and chlorin compounds (e.g., compounds of Formula (I)), and compositions and optical devices incorporating the compounds of the disclosure. Also provided are methods of selecting appropriate metalloporphyrin and metallochlorin compounds for incorporation into optical devices wherein the devices mitigate damage to retinal epithelial cells while balancing changes to luminous transmission, discomfort glare, color distortion, and disruption of circadian rhythms.

Abstract: Novel Stannic protoporfin compositions exhibiting high purity and other characteristics, including a novel solubility profile and visual indicators suggesting increase pharmacological activity, including enhanced antiviral activity. Also disclosed are novel processes for making Stannic protoporfin according to a process that requires fewer steps than known processes. Methods of treating patients before a scheduled insult such as surgy by administering a combination of stannic protoporfin and iron sucrose are provided. The present methods provide protection to photosensitive patients and those susceptible to post-operative complications.

Abstract: The present disclosure provides metalloporphyrin and metallochlorin compounds (e.g., compounds of Formula (II) and (III)), which are useful in the preparation of optical devices (e.g., contact lenses, intraocular lenses, implantable contact lenses) that protect retinal pigment epithelium by the selective blocking of blue light. Also provided are precursor porphyrin and chlorin compounds (e.g., compounds of Formula (I)), and compositions and optical devices incorporating the compounds of the disclosure. Also provided are methods of selecting appropriate metalloporphyrin and metallochlorin compounds for incorporation into optical devices wherein the devices mitigate damage to retinal epithelial cells while balancing changes to luminous transmission, discomfort glare, color distortion, and disruption of circadian rhythms.