Patents by Inventor Mark Alderson

Mark Alderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selectively disrupted whole-cell vaccine
    Patent number: 9827299
    Abstract: The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: November 28, 2017
    Assignees: Children's Medical Center Corporation, Path Vaccine Solutions, Fundacao Butantan
    Inventors: Richard Malley, Porter Anderson, Yingjie Lu, George A. Robertson, Mark Alderson, Jean-Francois Lucien Maisonneuve, Andrea Maria Tate, Waldely de Oliveira Dias, Viviane Maimoni Gonçalves
  • VACCINES AGAINST CHLAMYDIAL INFECTION
    Publication number: 20140056967
    Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
    Type: Application
    Filed: August 13, 2013
    Publication date: February 27, 2014
    Applicants: GlaxoSmithKline Biologicals S.A., Corixa Corporation
    Inventors: Brenda Barth, India Ajay, Mark Alderson, Jean-Francois L. Maisonneuve, Yves Lobert, Florence Bernadette Nozay, Martine Marchand, Pascal Mettens, Yasir A. Skeiky, Peter Probst
  • Vaccines against chlamydial infection
    Patent number: 8541007
    Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: September 24, 2013
    Assignees: GlaxoSmithKline Biologicals S.A., Corixa Corporation
    Inventors: Mark Alderson, Ajay Bhatia, Yves Lobet, Brenda Maisonneuve, Jean-Francois L Maisonneuve, Martine Marchand, Pascal Mettens, Florence Bernadette Nozay, Peter Probst, Samira H Skeiky
  • SELECTIVELY DISRUPTED WHOLE-CELL VACCINE
    Publication number: 20120251577
    Abstract: The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
    Type: Application
    Filed: October 12, 2010
    Publication date: October 4, 2012
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, FUNDACAO BUTANTAN, PATH VACCINE SOLUTIONS
    Inventors: Richard Malley, Porter Anderson, Yingjie Lu, George A. Robertson, Mark Alderson, Jean-Francois Lucien Maisonneuve, Andrea Maria Tate, Waldely de Oliveira Dias, Viviane Maimoni Gonçalves
  • Fusion proteins of antigens and their uses
    Patent number: 8143386
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 27, 2012
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Nero
  • VACCINES AGAINST CHLAMYDIAL INFECTION
    Publication number: 20110300206
    Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
    Type: Application
    Filed: December 21, 2010
    Publication date: December 8, 2011
    Applicants: GlaxoSmithKline Biologicals, sa, Corixa Corporation
    Inventors: Mark ALDERSON, Ajay BHATIA, Yves LOBET, Brenda MAISONNEUVE, Jean-Francois L. MAISONNEUVE, Martine MARCHAND, Pascal METTENS, Florence Bernadette NOZAY, Peter PROBST, Yasir A. SKEIKY, Samira H. SKEIKY
  • Fusion proteins of mycobacterium tuberculosis
    Patent number: 8071747
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: December 6, 2011
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of
    Patent number: 7976844
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: July 12, 2011
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of mycobacterium tuberculosis
    Patent number: 7973153
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: July 5, 2011
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Vaccines Against Chlamydial Infection
    Publication number: 20100172927
    Abstract: Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.
    Type: Application
    Filed: October 3, 2007
    Publication date: July 8, 2010
    Inventors: Mark Alderson, Rhea Coler, Yves Lobet, Jean-Francois L. Maisonneuve, Pascal Mettens, Peter Probst, Steven Reed
  • Fusion Proteins of Mycobacterium Tuberculosis
    Publication number: 20100015096
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: June 23, 2009
    Publication date: January 21, 2010
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Publication number: 20090281168
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Application
    Filed: October 29, 2007
    Publication date: November 12, 2009
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Nero
  • VACCINES AGAINST CHLAMYDIAL INFECTION
    Publication number: 20090022755
    Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
    Type: Application
    Filed: March 24, 2006
    Publication date: January 22, 2009
    Applicants: GLAXOSMITHKLINE BIOLOGICALS SA, CORIXA CORPORATION
    Inventors: Brenda Barth, Ajay Bhatia, Mark Alderson, Jean-Francois L. Maisonneuve, Yves Lobet, Florence Bernadette Nozay, Martine Marchand, Pascal Mettens, Yasir A. Skeiky, Peter Probst
  • Fusion proteins of mycobacterium tuberculosis
    Publication number: 20090018095
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 15, 2009
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of mycobacterium tuberculosis
    Publication number: 20090004226
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 1, 2009
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of mycobacterium tuberculosis
    Publication number: 20080317716
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 25, 2008
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of Mycobacterium tuberculosis
    Publication number: 20080161263
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 3, 2008
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of antigens and their uses
    Patent number: 7335369
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: February 26, 2008
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Neto
  • Fusion proteins of mycobacterium tuberculosis
    Patent number: 7261897
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: August 28, 2007
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of
    Patent number: 7186412
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: March 6, 2007
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson