Abstract: There is herein described a dental kit comprising a dental aligner or mouth tray and dissolvable films. More particularly, there is described a dental kit comprising a dental aligner or mouth tray and dissolvable films wherein the dental aligner acts to straighten teeth and the dissolvable film may 5 contain active ingredients that may promote whitening and/or reduction of dental hypersensitivity (DH) in teeth.

Abstract: There is herein described a teeth whitening strip or film. In particular, the present invention relates to a dissolvable or substantially dissolvable hydrogen peroxide (H2O2) teeth whitening strip or film comprising a concentration of hydrogen peroxide (H2O2) at or above 10 wt. % of the strip or film. There is also described a process for the manufacture of a dissolvable or substantially dissolvable tooth whitening strip or film along with the method of using a strip or film comprising a concentration of hydrogen peroxide (H2O2) at or above 10 wt. % of the strip or film to whiten and/or bleach teeth.

Abstract: The present invention provides oral care compositions. The compositions may be provided in a solid form, such as a film. The compositions can comprise one or more film forming polymers, one or more bioadhesive agents, one or more plasticizers, benzocaine (and optionally one or more further active ingredients), one or more polymeric solvents, and an aqueous solvent. The oral care composition can be a solid or semi-solid composition up to a temperature of at least 40° C. Methods of providing such an oral care compositions are also provided herein.

Abstract: A tooth whitening and/or tooth sensitivity strip or film comprising: about 1-20 wt. % hydroxyapatite (HAP). A process for the manufacture of a tooth whitening strip or film, the process comprising at least the steps of: —mixing at least one or a combination of polyvinylpyrrolidone (PVP) polymers wherein the amount of the polyvinylpyrrolidone (PVP) polymers is greater than 75 wt. % of the film or strip; and —an amount at least about 1-20 wt. % hydroxyapatite (HAP); and —at least one or a combination of polycarbophils; —with water to provide an aqueous tooth whitening liquid; —applying the aqueous tooth whitening liquid to a substrate to provide a substrate carrying the aqueous tooth whitening liquid; —drying the aqueous tooth whitening liquid to provide a tooth whitening film on the substrate, said film having a thickness from about 50 pm to about 500 pm.

Abstract: The present invention provides a tooth whitening film. The tooth whitening film comprises a dental bleaching agent comprising one or both of a non-hydrogen peroxide bleaching agent and hydrogen peroxide in a hydrogen peroxide-polymer complex, one or more polyphosphates, said one or more polyphosphates comprising one or more cyclic polyphosphates, one or more water soluble film-forming polymers, one or more plasticizers and one or more emulsifiers, wherein the film has a thickness from about 50 ?m to about 500 ?m. A kit comprising one or more such films having a thickness from about 50 ?m to about 150 ?m and a dental aligner is also provided. A process for the manufacture of the film is also provided, together with a method of using such a film to bleach teeth.

Abstract: The present invention provides oral care compositions. The compositions may be provided in a solid form, such as a film. The compositions can comprise one or more film forming polymers, one or more bioadhesive agents, one or more plasticizers, benzocaine (and optionally one or more further active ingredients), one or more polymeric solvents, and an aqueous solvent. The oral care composition can be a solid or semi-solid composition up to a temperature of at least 40° C. Methods of providing such an oral care compositions are also provided herein.

Abstract: The present invention provides oral compositions. The compositions may be provided in a solid form, such as a film. The compositions can comprise one or more film forming polymers, one or more bioadhesive agents, one or more active agents, one or more polymeric solvents, and an aqueous solvent, with the proviso that the composition does not comprise benzocaine. The active agent(s) preferably are effective for a range of effects. The oral composition can be a solid or semi-solid composition up to a temperature of at least 40° C. Methods of providing such an oral compositions and methods of applying them to an oral or buccal cavity are also provided herein.

Abstract: The present invention provides oral care compositions. The compositions may be provided in a solid form, such as a film. The compositions can comprise one or more film forming polymers, one or more bioadhesive agents, one or more plasticizers, benzocaine (and optionally one or more further active ingredients), one or more polymeric solvents, and an aqueous solvent. The oral care composition can be a solid or semi-solid composition up to a temperature of at least 40° C. Methods of providing such an oral care compositions are also provided herein.

Abstract: This disclosure relates to a controlled-release composition containing a water-swellable linear polymer together with an active agent. The water-swellable linear polymer is obtained by reacting together: (a) a polyethylene oxide of number average molecular weight less than or equal to 4000 g/mol; (b) an aliphatic diol; and (c) a difunctional isocyanate. The ratio of components (a) to (b) to (c) is in the range of 0.01-0.1 to 1 to 1.01-1.1 in terms of equivalent weights. The amount of the polyethylene oxide is less than 50 wt % of the polymer. The polymer has a water swelling percentage of 20-100%.

Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.

Abstract: This disclosure relates to a controlled-release composition containing a water-swellable linear polymer together with an active agent. The water-swellable linear polymer is obtained by reacting together: (a) a polyethylene oxide of number average molecular weight less than or equal to 4000 g/mol; (b) an aliphatic diol; and (c) a difunctional isocyanate. The ratio of components (a) to (b) to (c) is in the range of 0.01-0.1 to 1 to 1.01-1.1 in terms of equivalent weights. The amount of the polyethylene oxide is less than 50 wt % of the polymer. The polymer has a water swelling percentage of 20-100%.

Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.

Abstract: One embodiment provides an insert, which includes a non-degradable hydrogel matrix and clindamycin hydrochloride in contact with the matrix, wherein the insert is suitable for mammalian intravaginal, buccal, or intrarectal use. Methods of using and making the insert are also provided.