Patents by Inventor Mark Allen Osborne

Mark Allen Osborne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100130368
    Abstract: Provided herein is a method of determining a sequence of a target polynucleotide. The method can include the steps of a) providing a device including an array of relatively short polynucleotides and relatively long polynucleotides immobilised on a surface of a solid support, wherein the relatively long polynucleotides are fragments of the target polynucleotide and wherein the relatively long polynucleotides are separated by a distance of at least 10 nm, whereby parts of the relatively long polynucleotides that extend beyond the relatively short polynucleotides can be individually optically resolved; and b) determining the sequence of the target polynucleotide by detecting incorporation of nucleotides into strands complementary to the relatively long polynucleotide fragments using fluorescent labels associated with the incorporated nucleotides. Also provided is system for determining a sequence of a target polynucleotide. The system can include means for carrying out steps a) and b) of the above method.
    Type: Application
    Filed: August 24, 2009
    Publication date: May 27, 2010
    Inventors: Shankar Balasubramanian, Colin Barnes, David Klenerman, Mark Allen Osborne
  • Patent number: 7232656
    Abstract: The invention is directed to a method for analysing genome wide variation in an individual. The method comprises randomly fragmenting the individual's genome and generating sequence reads of multiple bases on all fragments of the individual's genome, aligning the sequence reads generated with a known genomic reference sequence, and analysing variations between the sequence reads derived from the individual's genome and the known genomic reference sequence.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: June 19, 2007
    Assignee: Solexa Ltd.
    Inventors: Shankar Balasubramanian, David Klenerman, Colin Barnes, Mark Allen Osborne
  • Publication number: 20040106110
    Abstract: A device comprising an array of molecules immobilised on a solid surface is disclosed, wherein the array has a high density of relatively short molecules and relatively long polynucleotides immobilised on the surface of a solid support, wherein the polynucleotides are at a density that permits individual resolution of those parts thereof that extend beyond the relatively short molecules.
    Type: Application
    Filed: May 22, 2002
    Publication date: June 3, 2004
    Applicant: Solexa, Ltd.
    Inventors: Shankar Balasubramanian, David Klenerman, Colin Barnes, Mark Allen Osborne