Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A spout having a one piece molded body including two or more quick disconnect ports, the quick disconnect ports constructed and arranged to attach two or more attachments. The spout can have two, three or more ports. The ports can be for a liquid and a gas, for example coffee and an air line to recover condensate and recirculate the recovered coffee. The spout can be heat welded to a bag containing a liquid. The ports can have different diameters to facilitate the attachments.

Abstract: A manufacturing fixture includes a rigid base defining a control plane. A first cone locator pin has a first longitudinal axis. The first cone locator pin is connected to the rigid base with the first longitudinal axis orthogonal to the control plane to engage a complementary locating aperture defined in a workpiece. The first cone locator pin engages the complementary locating aperture to locate the workpiece and constrain translation of the workpiece with respect to the control plane. A second cone locator pin has a second longitudinal axis. The second cone locator pin is connected to the rigid base with the second longitudinal axis orthogonal to the control plane to engage a complementary locating hole defined in a workpiece. The second cone locator pin engages the complementary locating hole to locate the workpiece and prevent rotation of the workpiece about the first longitudinal axis.

Abstract: In one embodiment, a reconfigurable vehicle interior assembly is provided. The assembly includes a trim member including a plurality of first elastically deformable mating members and a vehicle interior carrier component including a plurality of second elastically deformable mating members. Each of the first elastically deformable mating members matingly engages with at least one of the second elastically deformable mating members in order to couple the trim member to the vehicle interior carrier component. The first and second elastically deformable mating members collectively form a plurality of elastic averaging couplings.

Abstract: A manufacturing fixture includes a rigid base defining a control plane. A first cone locator pin has a first longitudinal axis. The first cone locator pin is connected to the rigid base with the first longitudinal axis orthogonal to the control plane to engage a complementary locating aperture defined in a workpiece. The first cone locator pin engages the complementary locating aperture to locate the workpiece and constrain translation of the workpiece with respect to the control plane. A second cone locator pin has a second longitudinal axis. The second cone locator pin is connected to the rigid base with the second longitudinal axis orthogonal to the control plane to engage a complementary locating hole defined in a workpiece. The second cone locator pin engages the complementary locating hole to locate the workpiece and prevent rotation of the workpiece about the first longitudinal axis.

Abstract: A reconfigurable fixture and method for holding a sheet metal part for processing, assembly, or inspection is provided. The reconfigurable fixture includes a holding container made of a flexible material, and holding granules at least partially filling the holding container. The holding container and the holding granules cooperate to conform to the sheet metal part when the sheet metal part is placed on the holding container.

Abstract: In one embodiment, a reconfigurable vehicle interior assembly is provided. The assembly includes a trim member including a plurality of first elastically deformable mating members and a vehicle interior carrier component including a plurality of second elastically deformable mating members. Each of the first elastically deformable mating members matingly engages with at least one of the second elastically deformable mating members in order to couple the trim member to the vehicle interior carrier component. The first and second elastically deformable mating members collectively form a plurality of elastic averaging couplings.

Abstract: A control system for a failure mode testing system is described. The control system employs at least one control algorithm that enables the testing system to be operated at optimal pressure and frequency levels in order to generate a desired system response, such as a desired energy level and desired slope of the fast Fourier transform of the system response. Also described are a pressure dither system and a frequency ringing system for enhancing the operation of the actuator cylinders of the failure mode testing system. All three of the systems can be incorporated, either singularly or in combination, into a computer software program that can be employed to operate and control the failure mode testing system.

Abstract: A control system for a failure mode testing system is described. The control system employs at least one control algorithm that enables the testing system to be operated at optimal pressure and frequency levels in order to generate a desired system response, such as a desired energy level and desired slope of the fast Fourier transform of the system response. Also described are a pressure dither system and a frequency ringing system for enhancing the operation of the actuator cylinders of the failure mode testing system. All three of the systems can be incorporated, either singularly or in combination, into a computer software program that can be employed to operate and control the failure mode testing system.

Abstract: A control system for a failure mode testing system is described. The control system employs at least one control algorithm that enables the testing system to be operated at optimal pressure and frequency levels in order to generate a desired system response, such as a desired energy level and desired slope of the fast Fourier transform of the system response. Also described are a pressure dither system and a frequency ringing system for enhancing the operation of the actuator cylinders of the failure mode testing system. All three of the systems can be incorporated, either singularly or in combination, into a computer software program that can be employed to operate and control the failure mode testing system.

Abstract: A control system for a failure mode testing system is described. The control system employs at least one control algorithm that enables the testing system to be operated at optimal pressure and frequency levels in order to generate a desired system response, such as a desired energy level and desired slope of the fast Fourier transform of the system response. Also described are a pressure dither system and a frequency ringing system for enhancing the operation of the actuator cylinders of the failure mode testing system. All three of the systems can be incorporated, either singularly or in combination, into a computer software program that can be employed to operate and control the failure mode testing system.