Patents by Inventor Mark AMARATUNGA
Mark AMARATUNGA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10839945Abstract: The present invention provides improved methods for maintaining the physical separation and identity integrity of a biological cellular sample from a patient during processing. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods of the invention find particular utility in processing patient samples for use in cell therapy.Type: GrantFiled: July 6, 2015Date of Patent: November 17, 2020Assignee: Global Life Sciences Solutions USA LLCInventors: Mohan Mark Amaratunga, Nicholas Thomas, Philip Vanek
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Publication number: 20190298953Abstract: A component—such as a respitratory mask—for use in a user circuit for delivering a flow of a treatment gas to the airway of a patient includes a housing. The housing includes an exterior portion having a number of exterior surfaces positioned to be exposed to a surrounding environment. The housing further includes an interior portion having a number of interior surfaces (30) defining a passageway through the housing. The exterior portion has a first heat capacity and the interior portion has a second heat capacity which is less than the first heat capacity.Type: ApplicationFiled: June 27, 2017Publication date: October 3, 2019Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Robert William BAIKO, Mark AMARATUNGA
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Publication number: 20170161466Abstract: The present invention provides improved methods for maintaining the physical separation and identity integrity of a biological cellular sample from a patient during processing. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods of the invention find particular utility in processing patient samples for use in cell therapy.Type: ApplicationFiled: July 6, 2015Publication date: June 8, 2017Inventors: Mohan Mark Amaratunga, Nicholas Thomas, Philip Vanek
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Publication number: 20110070596Abstract: Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.Type: ApplicationFiled: February 15, 2010Publication date: March 24, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Nichole Lea Wood, Mohan Mark Amaratunga, Hans Grade, Faisal Ahmed Syud, Anup Sood, Reginald Donovan Smith, Ayse Betul Dinc, Amy Casey Williams, Anthony John Murray, Gregory Daryll Goddard
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Publication number: 20090158822Abstract: A system for measuring one or more ultrasound parameters of a suspension comprising particulate biomaterial dispersed in a liquid carrier comprising, a bioprocessor for processing the particulate biomaterial; an immersible device comprising an ultrasound probes and a reflector; a housing, that fixes the probe and the reflector at positions with a space in between the probe surface and the reflective surface, comprising an opening into the housing that is of a size sufficient to allow the suspension to flow into the space between the probe surface and the reflective surface; an ultrasound wave generator/receiver device; and a signal processing device.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Zongqi Sun, Mohan Mark Amaratunga, Nicole Lea Wood, Christopher James Sevinsky
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SYSTEMS AND METHODS FOR HIGH-RESOLUTION IN VIVO IMAGING OF BIOCHEMICAL ACTIVITY IN A LIVING ORGANISM
Publication number: 20080118439Abstract: This invention relates to multifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these multifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the multifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises a plurality of activatable contrast agents or dyes, at least two of which are different from one another, wherein at least one of the activatable contrast agents can be activated or turned “on” only in the presence of a particular event.Type: ApplicationFiled: October 19, 2007Publication date: May 22, 2008Applicant: GENERAL ELECTRIC COMPANYInventors: Ileana Hancu, Mohan Mark Amaratunga, Denyce Kramer Wicht, Paritosh Dhawale, Nadeem Ishaque, Faisal Ahmed Syud, Bruce Fletcher Johnson, Amy Casey Williams -
Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
Patent number: 7303741Abstract: This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event.Type: GrantFiled: September 23, 2002Date of Patent: December 4, 2007Assignee: General Electric CompanyInventors: Ileana Hancu, Mohan Mark Amaratunga, Denyce Kramer Wicht, Paritosh Dhawale, Nadeem Ishaque, Faisal Ahmed Syud, Bruce Fletcher Johnson, Amy Casey Williams -
Publication number: 20070259330Abstract: The present invention relates to the isolation of human stem cells for use e.g. in cell therapy. More specifically, the invention is a method of separating mononuclear cells from human blood, which method comprises providing a human blood sample together with density gradient media (DGM) in a container; spinning the container comprising blood and DGM; and collecting the DGM fraction that comprises mononuclear cells; wherein the DGM has a density which is >1.080 and <1.090 g/cm3 as measured at 25° C. The invention also relates to bags and tubes which contain density gradient media wherein the density and osmolality has been optimized for use in the present method, preferably as kits.Type: ApplicationFiled: April 25, 2007Publication date: November 8, 2007Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Gregory Daryll Goddard, Mohan Mark Amaratunga, Cyndy D. Sanberg, James van Alstine, Oleg Kuzmenok
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Patent number: 7205385Abstract: A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.Type: GrantFiled: November 12, 2004Date of Patent: April 17, 2007Assignee: General Electric CompanyInventors: Brian James Grimmond, Bahram Moasser, Mohan Mark Amaratunga
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Publication number: 20040265235Abstract: Magnetic resonance (“MR”) contrast-enhancing agents comprise poly(amino acid) backbone chain conjugated to chelating moieties that comprise a plurality of carboxylic acid groups that form coordination complexes with paramagnetic ions. A method for detecting atherosclerotic plaque areas comprises administering at least one of these contrast agents into a subject; and obtaining and comparing MR images of and MR signals from the plaque areas before and after administering the contrast agent. The method can be used to assess an effectiveness of a prescribed course of treatment for atherosclerosis.Type: ApplicationFiled: June 26, 2003Publication date: December 30, 2004Inventors: Egidijus Edward Uzgiris, Mohan Mark Amaratunga, William Thomas Dixon, Paritosh Jayant Dhawale, Ahmad Nadeem Ishague
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Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
Publication number: 20040057903Abstract: This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event.Type: ApplicationFiled: September 23, 2002Publication date: March 25, 2004Inventors: Ileana Hancu, Mohan Mark Amaratunga, Denyce Kramer Wicht, Paritosh Dhawale, Nadeem Ishaque, Faisal Ahmed Syud, Bruce Fletcher Johnson, Amy Casey Williams -
Publication number: 20040014934Abstract: A method for the production of a polyestercarbonate comprises (i) providing at least one dihydroxyaromatic compound (ii) providing a carbonate precursor and (iii) providing at least one solid, biosynthetically derived, aliphatic alpha-omega dicarboxylic acid having about 10 to about 22 carbon atoms and having a nitrogen content of not more than about 55 ppm, and reacting interfacially in the presence of a base said dihydroxyaromatic compound, said carbonate precursor and said dicarboxylic acid.Type: ApplicationFiled: July 19, 2002Publication date: January 22, 2004Applicant: General Electric CompanyInventors: Herman Otto Krabbenhoft, Mohan Mark Amaratunga, David Paul Mobley
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Systems and methods for making prediction on energy consumption of energy-consuming systems or sites
Publication number: 20030061091Abstract: An energy-consumption predicting system remotely measures amounts of energy consumed by energy-consuming systems or an energy-consuming site; monitors and compares the real energy usage of the systems or site against expected or predicted values for energy consumption; analyzes and determines likely causes for variances between the real and the predicted values; and recommends to the energy user actions for achieving optimum operation of the systems or site. The energy-consumption predicting system can also forecast the energy usage of the energy-consuming site. The predicted energy usage amounts are outputs of a transfer function that relates the amounts of energy consumed to the operating parameters and other energy-related variables of the energy-consuming systems or site. The energy-consumption predicting system also permits remote access and interaction by the user and allows for integrating energy-related information into an overall strategy for managing the energy-consuming site.Type: ApplicationFiled: September 25, 2001Publication date: March 27, 2003Inventors: Mohan Mark Amaratunga, Srinivas Krishnaswamy Bagepalli, Lynn-Ann DeRose, Judith Ann Guzzo, Joseph James Salvo -
Patent number: 6498271Abstract: Aliphatic tricarboxylic acids, as exemplified by 9-carboxy-1,18-octadecanedioic acid, may be prepared by the biotransformation of an olefinic monocarboxylic acid such as oleic acid to the corresponding olefinic dicarboxylic acid, preferably 1,18-octadec-9-enedioic acid, in the presence of a strain of yeast, such as a strain of Candida tropicalis, followed by the carboxylation of the olefinic dicarboxylic acid by reaction with carbon monoxide and water in the presence of a catalyst. The product tricarboxylic acids are useful as branching agents for polycarbonates.Type: GrantFiled: January 10, 2002Date of Patent: December 24, 2002Assignee: General Electric CompanyInventors: David Paul Mobley, Mohan Mark Amaratunga, John Henry Lobos
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Publication number: 20020169339Abstract: Aliphatic tricarboxylic acids, as exemplified by 9-carboxy-1,18-octadecanedioic acid, may be prepared by the biotransformation of an olefinic monocarboxylic acid such as oleic acid to the corresponding olefinic dicarboxylic acid, preferably 1,18-octadec-9-enedioic acid, in the presence of a strain of yeast, such as a strain of Candida tropicalis, followed by the carboxylation of the olefinic dicarboxylic acid by reaction with carbon monoxide and water in the presence of a catalyst. The product tricarboxylic acids are useful as branching agents for polycarbonates.Type: ApplicationFiled: January 10, 2002Publication date: November 14, 2002Inventors: David Paul Mobley, Mohan Mark Amaratunga, John Henry Lobos
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Patent number: 6458899Abstract: Aliphatic tricarboxylic acids, as exemplified by 9-carboxy-1,18-octadecanedioic acid, may be prepared by the biotransformation of an olefinic monocarboxylic acid such as oleic acid to the corresponding olefinic dicarboxylic acid, preferably 1,18-octadec-9-enedioic acid, in the presence of a strain of yeast, such as a strain of Candida tropicalis, followed by the carboxylation of the olefinic dicarboxylic acid by reaction with carbon monoxide and water in the presence of a catalyst. The product tricarboxylic acids are useful as branching agents for polycarbonates.Type: GrantFiled: March 20, 2001Date of Patent: October 1, 2002Assignee: General Electric CompanyInventors: David Paul Mobley, Mohan Mark Amaratunga, John Henry Lobos, Sukhendu Bikash Hait, Andrew James Caruso
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Patent number: 6365702Abstract: A method for preparing a polyestercarbonate copolymer using solid state polymerization and polyestercarbonates prepared thereby is described. The method comprises preparing a mixture comprising partially crystalline bisphenol A polycarbonate oligomer and hydroxy acids, aliphatic diacids, cycloaliphatic diacids, aromatic diacids or aromatic triacids and subjecting that mixture to solid state polymerization to afford a polyestercarbonate copolymer.Type: GrantFiled: May 31, 2001Date of Patent: April 2, 2002Assignee: General Electric CompanyInventors: Sukhendu Bikash Hait, Mohan Mark Amaratunga, David Paul Mobley