Patents by Inventor Mark Anastasio

Mark Anastasio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220054017
    Abstract: Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system that incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system generates tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system.
    Type: Application
    Filed: November 1, 2021
    Publication date: February 24, 2022
    Applicant: TomoWave Laboratories, Inc.
    Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Mark Anastasio
  • Patent number: 11160456
    Abstract: Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system that incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system generates tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: November 2, 2021
    Assignee: Tomowave Laboratories, Inc.
    Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Mark Anastasio
  • Publication number: 20210321874
    Abstract: Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
    Type: Application
    Filed: April 22, 2021
    Publication date: October 21, 2021
    Applicant: California Institute of Technology
    Inventors: Lihong Wang, Liming Nie, Xin Cai, Konstantin Maslov, Mark A. Anastasio, Chao Huang, Robert W. Schoonover
  • Patent number: 11020006
    Abstract: Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: June 1, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Lihong V. Wang, Liming Nie, Xin Cai, Konstantin Maslov, Mark A. Anastasio, Chao Huang, Robert W. Schoonover
  • Publication number: 20210150779
    Abstract: Systems and methods for reconstructing an image of a subject or object based on a plurality of measured signals representing the subject or object obtained by an imaging device are disclosed. The systems and methods reconstruct the image of the subject or object by performing an iterative reconstruction method to produce a plurality of intermediate images and the image of the subject, and transforming at least one selected intermediate image from the plurality of intermediate images using a quasi-projection operator. The quasi-projection operator includes a deep-learning model configured to map the at least one selected intermediate image to at least one regularized intermediate image. In addition, systems and methods for training the deep-learning model using a training data set that includes a plurality of training images and a plurality of corresponding training object images is disclosed.
    Type: Application
    Filed: June 18, 2018
    Publication date: May 20, 2021
    Applicant: Washington University
    Inventors: Mark ANASTASIO, Thomas MATTHEWS, Brendan KELLY
  • Publication number: 20200260960
    Abstract: A system and method for generating at least one optimized functional images of a lesion region of a subject is provided. The system includes a diffuse optical tomography (DOT) device, and a computing device. The DOT device is configured to acquire lesion functional data of an imaging volume including the lesion region of the breast and reference functional data from a corresponding imaging volume including healthy tissue within a contralateral breast. The computing device is programmed to generate at least one functional image of the breast by reconstructing the functional data at the plurality of regions including the lesion region and the surrounding adjacent background region. The functional images may be reconstructed by an optimization method regularized a preliminary estimate generated by applying a truncated pseudoinverse matrix of a weight matrix to the functional data. The optimized functional images relate to levels of hemoglobin at the voxels.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 20, 2020
    Inventors: Quing Zhu, Mark Anastasio, Shihab Uddin
  • Patent number: 10653321
    Abstract: Systems and methods for improving limited-view photoacoustic tomography using an acoustic reflector are described. In particular, an acoustic reflector and ultrasonic transducer array are integrated to provide a virtual array that enhances the field of view of the ultrasonic transducer array, thereby improving the quality of photoacoustic tomography images obtained using the systems and methods described herein.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: May 19, 2020
    Assignee: Washington University
    Inventors: Lihong Wang, Bin Huang, Jun Xia, Konstantin Maslov, Mark Anastasio
  • Patent number: 10467741
    Abstract: A method for optimizing a CT simulation protocol for different size patients for contouring and segmentation of organs and tumors. The method scanning different size phantoms, cadavers, or patients with a CT scanning x-ray tube to create a set of images and to create data sets for each different size phantoms, cadavers, or patients and then calculating an image quality index (IQI) as a benchmark for contouring accuracy. Finding an optimal IQI that characterizes patients of different sizes and using the optimal IQI to determine the accuracy of the contouring and segmentation of A CT simulation protocol for a patient.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: November 5, 2019
    Assignee: Washington University
    Inventors: Hua Li, Sasa Mutic, Mark Anastasio
  • Publication number: 20170367586
    Abstract: Systems and methods for improving limited-view photoacoustic tomography using an acoustic reflector are described. In particular, an acoustic reflector and ultrasonic transducer array are integrated to provide a virtual array that enhances the field of view of the ultrasonic transducer array, thereby improving the quality of photoacoustic tomography images obtained using the systems and methods described herein.
    Type: Application
    Filed: November 12, 2014
    Publication date: December 28, 2017
    Inventors: Lihong WANG, Bin HUANG, Jun XIA, Konstantin MASLOV, Mark ANASTASIO
  • Publication number: 20160310083
    Abstract: A respiratory-gated photoacoustic computed tomography system is disclosed that includes a respiratory motion sensor operatively coupled to a photoacoustic computed tomography system. The respiratory motion sensor monitors respiratory motion of a subject by measuring changes in the levels of a coupling fluid within which the subject is immersed.
    Type: Application
    Filed: December 22, 2014
    Publication date: October 27, 2016
    Applicant: Washington University
    Inventors: Lihong WANG, Jun XIA, Konstantin MASLOV, Wanyi CHEN, Mark ANASTASIO
  • Publication number: 20160262628
    Abstract: Systems and methods for improving limited-view photoacoustic tomography using an acoustic reflector are described. In particular, an acoustic reflector and ultrasonic transducer array are integrated to provide a virtual array that enhances the field of view of the ultrasonic transducer array, thereby improving the quality of photoacoustic tomography images obtained using the systems and methods described herein.
    Type: Application
    Filed: November 12, 2014
    Publication date: September 15, 2016
    Inventors: Lihong WANG, Bin HUANG, Jun XIA, Konstantin MASLOV, Mark ANASTASIO
  • Publication number: 20160253443
    Abstract: A method for optimizing a CT simulation protocol for different size patients for contouring and segmentation of organs and tumors. The method scanning different size phantoms, cadavers, or patients with a CT scanning x-ray tube to create a set of images and to create data sets for each different size phantoms, cadavers, or patients and then calculating an image quality index (IQI) as a benchmark for contouring accuracy. Finding an optimal IQI that characterizes patients of different sizes and using the optimal IQI to determine the accuracy of the contouring and segmentation of A CT simulation protocol for a patient.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 1, 2016
    Inventors: Hua Li, Sasa Mutic, Mark Anastasio
  • Publication number: 20150245771
    Abstract: Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
    Type: Application
    Filed: October 18, 2013
    Publication date: September 3, 2015
    Inventors: Lihong V. Wang, Liming Nie, Xin Cai, Konstantin Maslov, Mark A. Anastasio, Chao Huang, Robert W. Schoonover
  • Publication number: 20130190595
    Abstract: Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system has means for generate tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system.
    Type: Application
    Filed: January 23, 2013
    Publication date: July 25, 2013
    Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Mark Anastasio
  • Publication number: 20090129648
    Abstract: A method for reducing PROPELLER MRI data acquisition times, by combining k-space under-sampling and iterative reconstruction using NUFFT, while maintaining similar image quality as in PROPELLER MRI with sufficient k-space sampling. Iterative image reconstruction using NUFFT minimizes image artifacts produced with conventional PROPELLER image reconstruction in under-sampled acquisitions. The data acquisition and image reconstruction parameters are selected in order to achieve image quality similar to that of sufficiently-sampled PROPELLER acquisitions for significantly shorter imaging time. An advantage of using under-sampled PROPELLER imaging is a reduction in acquisition time by as much as 50% without introducing significant artifacts, and while maintaining other benefits of PROPELLER imaging.
    Type: Application
    Filed: November 15, 2007
    Publication date: May 21, 2009
    Inventors: Konstantinos Arfanakis, Mark A. Anastasio, Ashish A. Tamhane