Patents by Inventor Mark Anthony Ashwell

Mark Anthony Ashwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HPK1 antagonists and uses thereof
    Patent number: 11926625
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: March 12, 2024
    Assignee: Nimbus Saturn, Inc.
    Inventors: Neelu Kaila, Ian Linney, Stuart Ward, Grant Wishart, Benjamin Whittaker, William Sinko, Shawn Watts, Mark Anthony Ashwell, Byron Scott Delabarre
  • HPK1 ANTAGONISTS AND USES THEREOF
    Publication number: 20230117631
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
    Type: Application
    Filed: March 4, 2022
    Publication date: April 20, 2023
    Inventors: Neelu KAILA, Ian Linney, Stuart Ward, Grant Wishart, Benjamin Whittaker, William Sinko, Shawn Watts, Mark Anthony Ashwell, Byron Scott Delabarre
  • HPK1 ANTAGONISTS AND USES THEREOF
    Publication number: 20230096641
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
    Type: Application
    Filed: February 11, 2022
    Publication date: March 30, 2023
    Inventors: Neelu KAILA, Ian LINNEY, Stuart WARD, Grant WISHART, Benjamin WHITTAKER, William SINKO, Shawn WATTS, Mark Anthony ASHWELL, Byron Scott DELABARRE
  • Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines
    Patent number: 7378427
    Abstract: Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the specification.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: May 27, 2008
    Assignee: Wyeth
    Inventors: Brian Hugh Ridgway, William Jay Moore, Mark Anthony Ashwell, William Ronald Solvibile, Amy Tsai-Ting Lee, Molly Elizabeth Hoke, Madelene Antane, Amedeo A. Failli
  • Heterocyclic beta-3 adrenergic receptor agonists
    Patent number: 6605618
    Abstract: This invention provides compounds of Formula I having the structure wherein,  U, V, W, X, and Y are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: August 12, 2003
    Assignee: Wyeth
    Inventors: Mark Anthony Ashwell, William Ronald Solvibile, Dominick Anthony Quagliato, Albert John Molinari
  • Heterocyclic &bgr;3 adrenergic receptor agonists
    Patent number: 6537994
    Abstract: This invention provides compounds of Formula I having the structure wherein, U, V, and W are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: March 25, 2003
    Assignee: Wyeth
    Inventors: Mark Anthony Ashwell, William Ronald Solvibile
  • Heterocyclic beta-3 adrenergic receptor agonists
    Publication number: 20030018045
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 2, 2002
    Publication date: January 23, 2003
    Applicant: Wyeth
    Inventors: Mark Anthony Ashwell, William Ronald Solvibile, Dominick Anthony Quagliato, Albert John Molinari
  • Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine &bgr;-3 adrenergic receptor agonists
    Patent number: 6506901
    Abstract: This invention provides compounds of Formula I having the structure wherein A, B, Z, R and R1 are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 14, 2003
    Assignee: Wyeth
    Inventors: Robert John Steffan, Mark Anthony Ashwell, Jeffrey Claude Pelletier, William Ronald Solvibile, Edward Martin Matelan
  • Heterocyclic &bgr;-3 adrenergic receptor agonists
    Patent number: 6451814
    Abstract: This invention provides compounds of Formula I having the structure U, V, W, X, and Y are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: September 17, 2002
    Assignee: Wyeth
    Inventors: Mark Anthony Ashwell, William Ronald Solvibile, Dominick Anthony Quagliato, Albert John Molinari