Patents by Inventor Mark Anthony Tornetta

Mark Anthony Tornetta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIABLE HEAVY CHAIN ONLY LIBRARIES, METHODS OF PREPARATION THEREOF, AND USES THEREOF
    Publication number: 20250215616
    Abstract: The present disclosure relates to designs and applications of Variable Heavy Only (VHO) domain regions. The present disclosure provides a VHO library of polynucleotides encoding VHO domains, wherein the VHO domains are designed based on the Vh domain of a human Vh family, and a method of generating the VHO library. The present disclosure also provides a phage library displaying the VHO domains encoded by the VHO library through the use of M13 bacteriophage minor coat proteins such as pIX and pVII and a method of generating the phage library. The present disclosure also provides a method of screening the phage library to identify VHO candidates that are capable of binding a target of interest.
    Type: Application
    Filed: September 20, 2024
    Publication date: July 3, 2025
    Applicant: TAVOTEK BIOTHERAPEUTICS (HONG KONG) LIMITED
    Inventors: Brian WHITAKER, Mark Anthony TORNETTA, Mark L. CHIU, Man-Cheong FUNG
  • Variable heavy chain only libraries, methods of preparation thereof, and uses thereof
    Patent number: 12024796
    Abstract: The present disclosure relates to designs and applications of Variable Heavy Only (VHO) domain regions. The present disclosure provides a VHO library of polynucleotides encoding VHO domains, wherein the VHO domains are designed based on the Vh domain of a human Vh family, and a method of generating the VHO library. The present disclosure also provides a phage library displaying the VHO domains encoded by the VHO library through the use of M13 bacteriophage minor coat proteins such as pIX and pVII and a method of generating the phage library. The present disclosure also provides a method of screening the phage library to identify VHO candidates that are capable of binding a target of interest.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: July 2, 2024
    Assignee: Tavotek Biotherapeutics (Hong Kong) Limited
    Inventors: Brian Whitaker, Mark Anthony Tornetta, Mark L. Chiu, Man-Cheong Fung
  • VARIABLE HEAVY CHAIN ONLY LIBRARIES, METHODS OF PREPARATION THEREOF, AND USES THEREOF
    Publication number: 20220177870
    Abstract: The present disclosure relates to designs and applications of Variable Heavy Only (VHO) domain regions. The present disclosure provides a VHO library of polynucleotides encoding VHO domains, wherein the VHO domains are designed based on the Vh domain of a human Vh family, and a method of generating the VHO library. The present disclosure also provides a phage library displaying the VHO domains encoded by the VHO library through the use of M13 bacteriophage minor coat proteins such as pIX and pVII and a method of generating the phage library. The present disclosure also provides a method of screening the phage library to identify VHO candidates that are capable of binding a target of interest.
    Type: Application
    Filed: December 2, 2021
    Publication date: June 9, 2022
    Inventors: Brian Whitaker, Mark Anthony Tornetta, Mark L. Chiu, Man-Cheong Fung