Patents by Inventor Mark Applegate

Mark Applegate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220370941
    Abstract: A hydro-enhanced air cleaner is provided as a stand-alone unit or as a component of a heating, ventilation, air conditioning system for a building which cleans and purifies ambient air and is also capable of producing potable water in humid environments. The device includes a dehumidifier which extracts polluted humid air and produces condensate including water and pollutants which adhere to the water. A degasser is connected with the dehumidifier to purify and degas the condensate to produce deionized water and pollutants. A humidifier is connected with the degasser to vaporize at least a portion of the deionized water for delivery to a living space. Excess deionized water may be collected as a potable water supply. In accordance with a method, the apparatus is used to continuously recycle air within a building further continuously clean the air.
    Type: Application
    Filed: May 18, 2022
    Publication date: November 24, 2022
    Inventor: Mark Applegate
  • Publication number: 20170055561
    Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
    Type: Application
    Filed: October 3, 2016
    Publication date: March 2, 2017
    Inventors: Gail K. Naughton, David L. Horwitz, Mark Applegate, Joan Zeltinger, Jonathan Mansbridge, Andreas Kern, Lee K. Landeen, Anthony Ratcliffe, R. Emmett Pinney
  • Patent number: 9458486
    Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 4, 2016
    Assignee: Allergen, Inc.
    Inventors: Gail K. Naughton, David L. Horwitz, Mark Applegate, Joan Zeltinger, Jonathan Mansbridge, Andreas Kern, Lee K. Landeen, Anthony Ratcliffe, R. Emmett Pinney
  • Publication number: 20070077232
    Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 5, 2007
    Applicant: SkinMedica, Inc.
    Inventors: Gail Naughton, David Horwitz, Mark Applegate, Joan Zeltinger, Jonathan Mansbridge, Andreas Kern, Lee Landeen, Anthony Ratcliffe, R. Pinney
  • Patent number: 5843766
    Abstract: A tissue culture chamber is disclosed. The chamber is a casing that provides for growth of three-dimensional tissue, and more specifically for the growth of skin tissue, that can be grown, preserved in frozen form, and shipped to the end user in the same aseptic container. The tissue culture chamber includes a casing comprising a substrate within the casing designed to facilitate three-dimensional tissue growth on the surface of the substrate. The casing includes an inlet and an outlet port which assist the inflow and outflow of media. The casing also includes at least one flow distributor. In one embodiment, the flow distributor is a baffle, which is used to distribute the flow of the media within the chamber to create a continuous, uniform piece of three-dimensional tissue. In a second embodiment, the flow distributor is a combination of deflector plates, distribution channels, and a flow channel.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: December 1, 1998
    Assignee: Advanced Tissue Sciences, Inc.
    Inventors: Dawn Orton Applegate, Mark Applegate, Mark Baumgartner, John W. Bennett, John Danssaert, Robert Hardin, Lee Laiterman, Fred Schramm, William R. Tolbert