Abstract: An ultrasonic bond is formed using a bond tool foot having a waffle shape of thin protrusions and gaps between the protrusions. The tool is brought in contact with the ribbon to a depth to create depressions in a ribbon approximately 150 ?m or less from the underlying bonding surface. The tool is then brought down further into the ribbon to contact the portions of the ribbon between the depressions, such as an additional 25 to 50 ?m. The result is lightly bonded regions underneath the groove portions and highly bonded regions underneath the protrusions and around the perimeter of the bond. In another embodiment, an ultrasonic bond is formed along a partial width of a ribbon.

Abstract: A processing system with reconfigurable instruction extensions includes a processor, programmable logic, a register file, and a load/store module. The processor executes a computer program comprising a set of computational instructions and at least one instruction extension. The programmable logic receives configuration information to configure the programmable logic for the instruction extension and executes the instruction extension. The register file is coupled to the programmable logic and stores data. The load/store module transfers the data directly between the register file and a system memory.

Abstract: The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which downregulation of MC5R is beneficial. Such diseases and/or conditions include, but are not limited to, acne, seborrhea, seborrheic dermatitis, cancer, and inflammatory diseases.

Abstract: The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which downregulation of MC5R is beneficial. Such diseases and/or conditions include, but are not limited to, acne, seborrhea, seborrheic dermatitis, cancer, and inflammatory diseases.

Abstract: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

Abstract: An alignment device for hole saw includes a first alignment member having a first end having an outer width slightly less than an inner diameter of the hole saw and serves as an alignment bearing surface therefor and a second end configured with a nose to be received adjacent a hole of a work piece and a draw bar and tightening member therewith for drawing the first alignment member against the work piece in a manner wherein the nose is self centering within the hole and thereby maintaining the first alignment member in a predetermined aligned position with respect to the work piece.

Abstract: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

Abstract: An ultrasonic bond is formed using a bond tool foot having a waffle shape of thin protrusions and gaps between the protrusions. The tool is brought in contact with the ribbon to a depth to create depressions in a ribbon approximately 150 ?m or less from the underlying bonding surface. The tool is then brought down further into the ribbon to contact the portions of the ribbon between the depressions, such as an additional 25 to 50 ?m. The result is lightly bonded regions underneath the groove portions and highly bonded regions underneath the protrusions and around the perimeter of the bond. In another embodiment, an ultrasonic bond is formed along a partial width of a ribbon.

Abstract: An ultrasonic bond is formed using a bond tool foot having a waffle shape of thin protrusions and gaps between the protrusions. The tool is brought in contact with the ribbon to a depth to create depressions in a ribbon approximately 150 ?m or less from the underlying bonding surface. The tool is then brought down further into the ribbon to contact the portions of the ribbon between the depressions, such as an additional 25 to 50 ?m. The result is lightly bonded regions underneath the groove portions and highly bonded regions underneath the protrusions and around the perimeter of the bond. In another embodiment, an ultrasonic bond is formed along a partial width of a ribbon.

Abstract: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

Abstract: A video processing system with reconfigurable instructions includes a processor, a first register file in the processor, an extension adapter, programmable logic, a second register file coupled to the programmable logic, and a load/store module. The processor executes a video application that contains an instruction extension not native to the instruction set of the processor. The extension adapter detects the instruction extension in the video application. The programmable logic device is configured to execute the instruction extension. The programmable logic device then executes the instruction extension. The load/store module transfers data between the first register file and the second register file, and transfers data directly between the second register file and a system memory for use by the processor in processing the video application.

Abstract: A method for padding, filtering, denoising, image enhancing and increased time-frequency acquisition is described for digitized data of a data set is described where unknown data is estimated using real data by adding unknown data points in a manner that the padding routine can estimate the interior data set including known and unknown data to a given accuracy on the known data points. The method also provides filtering using non-interpolating, well-tempered distributed approximating functional (NIDAF)-low-band-pass filters. The method also provides for symmetric and/or anti-symmetric extension of the data set so that the data set may be better refined and can be filtered by Fourier and other type of low frequency or harmonic filters.

Abstract: Disclosed is an implantable microspectrometer for the reagentless optical detection of an analyte in a sample fluid. The microspectrometer comprises an optical sampling cell having a cell housing defining a fluid inlet port and a fluid outlet port, the fluid inlet port configured to receive an optical sampling fluid from a test subject; an electromagnetic radiation source in communication with a first portion of the optical sampling cell housing and configured to irradiate at least a portion of the optical sampling fluid with electromagnetic radiation; and an electromagnetic radiation detector in communication with a second portion of the optical sampling cell housing and configured to detect electromagnetic radiation emanating from the optical sampling cell. In use, the implantable microspectrometer can optically detect at least one parameter of an analyte contained within the optical sampling fluid in the absence of an added reagent.

Abstract: A method for generating a net analyte signal calibration model for use in detecting and/or quantifying the amount of an analyte in a test subject. The net analyte signal can be generated by providing a set of in vivo infrared spectra for a test subject during a period in which an analyte concentration is essentially constant; calculating an optimal subspace of spectra that at least substantially describes all non-analyte dependent spectral variance in the in vivo spectra; providing a pure component infrared spectrum for the analyte; and calculating a net analyte signal spectrum from a data set comprising the optimal subspace spectra and the pure analyte spectrum. The net analyte signal calibration model can be used, for example, in measuring the concentration of analyte in a test subject, and/or for evaluating the analytical significance of an in vivo multivariate calibration model.

Abstract: A system and method for adding reconfigurable computational instructions to a reduced instruction set computer. A computer program contains instruction extensions not native to the instruction set of the processor core and is loaded into an instruction memory accessible by the processor core of the computer. The computer program is then detected for containing the instruction extension. The programmable logic device is then configured to execute the instruction extension. The programmable logic device then executes the instruction extension for use by the processor core in processing the computer program.

Abstract: A unitary foam packing element including a planar piece of foam which is precut with a plurality of score lines. The score lines define a first planar portion and a second planar portion, and enable the first planar portion to be folded over onto the second planar portion to thereby form a flat cavity between the first planar portion and the second planar portion. The score lines further define an end panel adjacent the second planar portion, which is adapted to be folded along a respective one of the score lines so as to form a first end wall of the flat cavity, and an intermediate portion between the first planar portion and the second planar portion, which is adapted to form a second end wall of the flat cavity that is opposite the first end wall.

Abstract: A fishing apparatus having particular utility in wade fishing includes a buoyant, board-like support member, a fish container secured to the support member for holding fish caught by the user, and a first bait container also secured to the support member for storing bait such as live bait. Other features of the fishing apparatus include a second bait container for storing bait such as fishing lures and tubular containers for supporting fishing rods and a landing net.

Abstract: A method for padding, filtering, denoising, image enhancing and increased time-frequency acquisition is described for digitized data of a data set is described where unknown data is estimated using real data by adding unknown data points in a manner that the padding routine can estimate the interior data set including known and unknown data to a given accuracy on the known data points. The method also provides filtering using non-interpolating, well-tempered distributed approximating functional (NIDAF)-low-band-pass filters. The method also provides for symmetric and/or anti-symmetric extension of the data set so that the data set may be better refined and can be filtered by Fourier and other type of low frequency or harmonic filters.

Abstract: A method and apparatus for reducing food and grease in a wastewater stream from a food service facility. Vacuum is supplied to a suction hose, which is used to remove food and grease from plates and utensils prior to these being introduced into the water flow. The food and grease is collected in a waste container for separate disposal. The suction hose may be fitted with a scrubber head for breaking up and removing the materials. The vacuum may be supplied by an air pressure operated vacuum transducer, or by an exhaust blower. The invention thus solves the problem of high BOD, FOG and TSS levels in wastewater streams from food service facilities, which generate excessive loads on both on-site septic systems and municipal waste water treatment plants.

Abstract: A backhoe loader is provided with a reversible operator's seat having a first working position facing the loader and a second working position facing the backhoe. A first hydraulic pump directs pressurized hydraulic fluid through a first supply line to loader control valves, stabilizer control valves and backhoe control valves that are mounted in series. A second hydraulic pumps directs pressurized hydraulic fluid through a second supply line to the first supply line upstream from the loader control valves. The second supply line is provided with a two-position solenoid valve. In its first position, the valve directs pressurized hydraulic fluid from the second hydraulic pump to sump. In its second position, the valve directs pressurized hydraulic fluid from the second hydraulic pump to the first supply line. The solenoid of the two-position solenoid valve is in electrical communication with a seat switch signaling the working position of the operator's seat.