Abstract: A new method and apparatus for detecting outliers, more specifically false-negatives and/or false-positives, in pharmaceutical mass screening experiments is provided which utilizes chemical descriptor methodology in conjunction with supervised learning techniques. This method employs the latent structure-activity relationship between the chemical compounds and the biological activity for the detection of such outliers. The method is applicable to individual compounds as well as to pools or mixture of compounds.

Abstract: This invention related to a multi-layered damped anchor shim adapted for use in a drum brake assembly. The anchor shim includes an inner surface and an outer surface which is adapted to contact the second ends of the brake shoes. The anchor shim includes a damping material applied to the inner surface thereof so as to be disposed between adjacent contacting areas of the outer surface of the inner retainer plate and the inner surface of the anchor shim to thereby reduce the transmission of noise from the brake shoes through the abutment assembly to the backing plate.