Patents by Inventor Mark Behnke

Mark Behnke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of cytosolic phospholipase A2
    Publication number: 20030144282
    Abstract: This invention provides substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Synthesis of clasto-lactacystin &bgr;-lactone and analogs thereof
    Patent number: 6566553
    Abstract: The present invention is directed to an improved synthesis of clasto-lactacystin-&bgr;-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-&bgr;-lactones, and analogs thereof and their use as proteosome inhibitors.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: May 20, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: François Soucy, Louis Plamondon, Mark Behnke, William Roush
  • Synthesis of clasto-lactacystin beta-lactone and analogs thereof
    Publication number: 20020016355
    Abstract: The present invention is directed to an improved synthesis of clasto-lactacystin-&bgr;-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-&bgr;-lactones, and analogs thereof and their use as proteosome inhibitors.
    Type: Application
    Filed: August 10, 2001
    Publication date: February 7, 2002
    Inventors: Francois Soucy, Louis Plamondon, Mark Behnke, William Roush
  • Synthesis of clasto-lactacystin &bgr;-lactone and analogs thereof
    Patent number: 6294560
    Abstract: The present invention is directed to an improved synthesis of clasto-lactacystin-&bgr;-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-&bgr;-lactones, and analogs thereof and their use as proteosome inhibitors.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: September 25, 2001
    Assignee: Millennium Pharmaceuticals, Inc..
    Inventors: François Soucy, Louis Plamondon, Mark Behnke, William Roush
  • Synthesis of clasto-lactacystin beta-lactone and analogs thereof
    Patent number: 6133308
    Abstract: The present invention is directed to an improved synthesis of clasto-lactacystin-.beta.-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-.beta.-lactones, and analogs thereof and their use as proteosome inhibitors.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: October 17, 2000
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Fran.cedilla.ois Soucy, Louis Plamondon, Mark Behnke, William Roush
  • Pyrrolidine derivatives inhibitors of leukotriene biosynthesis
    Patent number: 5594008
    Abstract: 2-(1-pyrrolidino)-benzoxazoles of general formula ##STR1## are disclosed which are inhibitors of leukotriene biosynthesis.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 14, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Kollol Pal, Mark Behnke, Julian Adams