Patents by Inventor Mark Blumenkranz

Mark Blumenkranz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11278448
    Abstract: Aspects of the invention include a device for fluid delivery to the ocular surface having a self-alignment system. The fluid delivery device includes a fluid package having a reservoir and one or more apertures, an actuator component configured to eject fluid from the reservoir through the one or more apertures and an image-based self-alignment system configured to align fluid ejected through the one or more apertures with a target location on the eye of a user. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: March 22, 2022
    Assignee: Kedalion Therapeutics, Inc.
    Inventors: Daniel Palanker, Mark Blumenkranz, Ehud Ivri, Reynaldo Quintana
  • Publication number: 20210153736
    Abstract: A visual function evaluation is performed using a sequence of interactions with a mobile device. A patient user may perform a variety of visual tests using the mobile device. The mobile device transmits the test results to a remote server implementing analysis of the visual function results using network service. The network service receives the test results, processes the results, and provides the processed results to a healthcare provider. The processed results may include trends of the user's visual function test performance. The healthcare provider, such as a physician, may optimize and administer treatment based on the data. Early detection of changes in visual function can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense.
    Type: Application
    Filed: July 2, 2020
    Publication date: May 27, 2021
    Inventors: Daniel PALANKER, Mark BLUMENKRANZ
  • Patent number: 10888454
    Abstract: Fluid delivery devices and methods are described, where the device may comprise a piezoelectric actuator operatively coupled to an ampoule with fluid, under a preloading force. The ampoule may comprise a thin-walled thermoplastic package which includes one or more apertures positioned on the wall of the ampoule. The piezoelectric actuator may be configured to clamp at least partially around the circumference of the ampoule and apply oscillations to its wall. The oscillations, typically in ultrasonic frequency, produce cycles of acoustic pressure in the fluid, leading to ejection of the fluid droplets or streams from the apertures.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: January 12, 2021
    Assignee: Kedalion Therapeutics, Inc.
    Inventors: Yehuda Ivri, Mark Blumenkranz, Daniel V. Palanker
  • Patent number: 10743761
    Abstract: A modular lens adapter system or kit is provided for mobile anterior and posterior segment ophthalmoscopy. Equipped with various lens adapter modules, respective lenses and a mobile imaging device, a user is provided with tools for various mobile ophthalmoscopy imaging applications. Eye care practitioners can use their existing lenses to customize the modular lens adapter system in a cost-effective way, which allows for mobile and remote capture, viewing, and utilization of clinical images. The various modules are also adaptable to nearly any type of phone or tablet regardless of its dimensions or presence of a protective case. The invention also addresses the need for fewer, smaller, less expensive, and easier to use ophthalmic imaging equipment, which is further important in enabling a broad base of users.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: August 18, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior Univeristy
    Inventors: David Myung, Robert Tienhan Chang, Lingmin He, Alex Nugent, Huynh P. Van, Ira G. Wong, Alexandre Jais, Mark Blumenkranz
  • Patent number: 10702140
    Abstract: A visual function evaluation is performed using a sequence of interactions with a mobile device. A patient user may perform a variety of visual tests using the mobile device. The mobile device transmits the test results to a remote server implementing analysis of the visual function results using network service. The network service receives the test results, processes the results, and provides the processed results to a healthcare provider. The processed results may include trends of the user's visual function test performance. The healthcare provider, such as a physician, may optimize and administer treatment based on the data. Early detection of changes in visual function can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: July 7, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Palanker, Mark Blumenkranz
  • Publication number: 20200138564
    Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.
    Type: Application
    Filed: December 20, 2019
    Publication date: May 7, 2020
    Inventors: William Culbertson, Mark Blumenkranz, David Angeley, George Marcellino, Michael Wiltberger, Dan Andersen
  • Publication number: 20200129287
    Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.
    Type: Application
    Filed: December 23, 2019
    Publication date: April 30, 2020
    Inventors: William Culbertson, Mark Blumenkranz, David Angeley, George Marcellino, Michael Wiltberger, Dan Andersen
  • Patent number: 10548715
    Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: February 4, 2020
    Assignee: OPTIMEDICA CORPORATION
    Inventors: William Culbertson, Mark Blumenkranz, David Angeley, George Marcellino, Michael Wiltberger, Dan Andersen
  • Patent number: 10548716
    Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: February 4, 2020
    Assignee: OPTIMEDICA CORPORATION
    Inventors: William Culbertson, Mark Blumenkranz, David Angeley, George Marcellino, Michael Wiltberger, Dan Andersen
  • Publication number: 20190314198
    Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 17, 2019
    Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
  • Publication number: 20190314196
    Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 17, 2019
    Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
  • Publication number: 20190314195
    Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 17, 2019
    Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
  • Publication number: 20190314197
    Abstract: Methods of administering a liquid formulation of an ophthalmic agent to a topical ocular location of an eye are provided. Aspects of the methods include delivering to the topical ocular location a dose of the liquid formulation that can be wholly accommodated by the tear film of the eye. Devices and kits for practicing the methods are also provided. The methods, compositions and kits find use in a variety of applications, including therapeutic, diagnostic and cosmetic applications.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 17, 2019
    Inventors: Ehud Ivri, Mark Blumenkranz, Peter Noymer
  • Publication number: 20190269325
    Abstract: A modular lens adapter system or kit is provided for mobile anterior and posterior segment ophthalmoscopy. Equipped with various lens adapter modules, respective lenses and a mobile imaging device, a user is provided with tools for various mobile ophthalmoscopy imaging applications. Eye care practitioners can use their existing lenses to customize the modular lens adapter system in a cost-effective way, which allows for mobile and remote capture, viewing, and utilization of clinical images. The various modules are also adaptable to nearly any type of phone or tablet regardless of its dimensions or presence of a protective case. The invention also addresses the need for fewer, smaller, less expensive, and easier to use ophthalmic imaging equipment, which is further important in enabling a broad base of users.
    Type: Application
    Filed: September 28, 2018
    Publication date: September 5, 2019
    Inventors: David MYUNG, Robert Tienhan CHANG, Lingmin HE, Alex NUGENT, Huynh P. VAN, Ira G. WONG, Alexandre JAIS, Mark BLUMENKRANZ
  • Publication number: 20190151409
    Abstract: The present disclosure provides pharmaceutical compositions and methods thereof for the treatment of age-related macular degeneration (AMD) in a subject by administering intravitreally a pharmaceutical composition adapted for gene therapy, comprising a vector having a nucleic acid sequence that encodes aflibercept.
    Type: Application
    Filed: December 12, 2018
    Publication date: May 23, 2019
    Inventors: Mark BLUMENKRANZ, Mehdi GASMI
  • Publication number: 20190100582
    Abstract: The present disclosure provides pharmaceutical compositions and methods thereof for the prevention or treatment of ocular neovascularization, such as AMD, in a subject, by administering to the subject a pharmaceutical composition comprising a rAAV vector having a nucleic acid sequence that encodes an anti-VEGF agent.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 4, 2019
    Inventors: Mark BLUMENKRANZ, Mehdi GASMI
  • Patent number: 10195017
    Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: February 5, 2019
    Assignee: Optimedica Corporation
    Inventors: William Culbertson, Mark Blumenkranz, David Angeley, George Marcellino, Michael Wiltberger, Dan Andersen
  • Publication number: 20180360659
    Abstract: A method of performing laser surgery in a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form an enclosed treatment pattern that is configured to form an enclosed capsulorhexis incision that includes a registration feature, and delivering the enclosed treatment pattern to target tissue in the patient's eye to form in an anterior lens capsule of the patient's eye the enclosed capsulorhexis incision that includes the registration feature. The registration feature is configured so that an edge of the target tissue formed by the enclosed capsulorhexis incision mates with an intraocular lens registration feature on an intraocular lens so as to rotationally register the intraocular lens relative to the registration feature.
    Type: Application
    Filed: July 27, 2018
    Publication date: December 20, 2018
    Inventors: William Culbertson, Mark Blumenkranz, David Angeley, George Marcellino, Michael Wiltberger, Dan Andersen
  • Patent number: 10092182
    Abstract: A modular lens adapter system or kit is provided for mobile anterior and posterior segment ophthalmoscopy. Equipped with various lens adapter modules, respective lenses and a mobile imaging device, a user is provided with tools for various mobile ophthalmoscopy imaging applications. Eye care practitioners can use their existing lenses to customize the modular lens adapter system in a cost-effective way, which allows for mobile and remote capture, viewing, and utilization of clinical images. The various modules are also adaptable to nearly any type of phone or tablet regardless of its dimensions or presence of a protective case. The invention also addresses the need for fewer, smaller, less expensive, and easier to use ophthalmic imaging equipment, which is further important in enabling a broad base of users.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: October 9, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David Myung, Robert Tienhan Chang, Lingmin He, Alex Nugent, Huynh P. Van, Ira G. Wong, Alexandre Jais, Mark Blumenkranz
  • Patent number: 10034795
    Abstract: A method of performing laser surgery in a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form an enclosed treatment pattern that is configured to form an enclosed capsulorhexis incision that includes a registration feature, and delivering the enclosed treatment pattern to target tissue in the patient's eye to form in an anterior lens capsule of the patient's eye the enclosed capsulorhexis incision that includes the registration feature. The registration feature is configured so that an edge of the target tissue formed by the enclosed capsulorhexis incision mates with an intraocular lens registration feature on an intraocular lens so as to rotationally register the intraocular lens relative to the registration feature.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: July 31, 2018
    Assignee: OPTIMEDICA CORPORATION
    Inventors: William Culbertson, Mark Blumenkranz, David Angeley, George Marcellino, Michael Wiltberger, Dan Andersen