Abstract: Provided herein are methods and pharmaceutical compositions related to the bacteria and microbial extracellular vesicles (mEVs) of Veillonella parvula Strain A that are useful as therapeutic agents, such as for treating neuroinflammation.

Abstract: Provided herein are methods and compositions related to Prevotella bacteria useful as therapeutic agents, e.g., for the treatment of psoriasis or atopic dermatitis.

Abstract: Provided herein are methods and pharmaceutical compositions related to processed microbial extracellular vesicles (pmEVs) that can be useful as therapeutic agents.

Abstract: Provided herein are methods and pharmaceutical compositions related to secreted microbial extracellular vesicles (smEVs) that can be useful as therapeutic agents.

Abstract: Provided herein are methods and compositions related to immune modulating Lactococcus strains useful as therapeutic agents. In certain embodiments, provided herein are methods of treating an immune disorder in a subject comprising administering to the subject a bacterial composition comprising Lactococcus lactis cremoris Strain A (ATCC Deposit Number PTA-125368).

Abstract: Provided herein are methods and compositions related to immune modulating Lactococcus strains useful as therapeutic agents. In certain embodiments, provided herein are methods of treating an immune disorder in a subject comprising administering to the subject a bacterial composition comprising Lactococcus lactis cremoris Strain A (ATCC Deposit Number PTA-125368).

Abstract: Provided herein are methods and compositions related to bacterium of genus Parabacteroides useful as therapeutic agents.

Abstract: Provided herein are methods and compositions related to immune modulating Lactococcus strains useful as therapeutic agents.

Abstract: A method is provided for reducing an immune response to an allergen or antigenic determinant thereof in a mammal by administering a modulator of the Notch signalling pathway.

Abstract: Conjugates comprising a plurality of modulators of the Notch signalling pathway chemically bound to a support structure are described. The conjugates are useful for modulation of the Notch signalling pathway and treatment of associated conditions.

Abstract: A method is disclosed for therapeutic modulation of Notch signalling by administering a construct comprising a multiplicity of bond, linked or immobilised modulators of Notch signalling.

Abstract: An inhibitor of the Notch signalling pathway is provided for use as an immunostimulant, for example as a vaccine adjuvant.

Abstract: A method for detecting modulators of Notch signalling is described. The method includes the step of monitoring Notch signalling in a cell of the immune system in the presence of a candidate modulator.

Abstract: An inhibitor of the Notch signalling pathway is provided for the manufacture of a medicament for use in the treatment of cancer.

Abstract: New uses of modulators of Notch signalling in therapy and corresponding methods of treatment are provided.

Abstract: The invention provides a collection of paired samples from a plurality of mutagenized animals, wherein each paired sample comprises: a first sample comprising genetic screening material of an animal; and a second sample comprising reproductive material of that same animal. A sample of reproductive material according to the invention can be used to generate a progeny animal carrying that same mutation. The invention also provides a collection of pairs of mutant genomes, comprising a plurality of animals carrying induced mutations and a corresponding plurality of sample genomic material, wherein a pair of mutated genomes of the collection comprises an animal having a genome containing an induced mutation and the animal's sample genomic material. The mutant animal, which might need to be bred to homozygosity, is useful for investigating the function of the gene. It might also be a useful animal model for studying human disease.