Patents by Inventor Mark Boer De

Mark Boer De has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-CD40L immunotoxins for the treatment of diseases
    Patent number: 6645494
    Abstract: An immunotoxin molecule is described which comprises an antibody specific for human CD40L antigen located on the surface of a human cell, coupled to a toxin molecule or active fragment thereof, wherein the binding of the immunotoxin to the CD40L molecule results in the killing of the CD40L expressing cell. The toxin molecule is especially a type-1 ribosome inactivating protein, or an active fragment thereof. The immunotoxin can be used for the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus, or T-cell malignancies.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: November 11, 2003
    Assignee: Tanox Pharma B.V.
    Inventors: Mark Boer De, Marcel Theodorus Hartog Den