Patents by Inventor Mark Boldin
Mark Boldin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10435689Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csf1r, HIF1?, Sla, Cepb?, and Bach1, and the like.Type: GrantFiled: December 5, 2017Date of Patent: October 8, 2019Assignee: California Institute of TechnologyInventors: David Baltimore, Ryan M. O'Connell, Konstantin Taganov, Mark Boldin
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Publication number: 20180187193Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csf1r, HIF1?, Sla, Cepb?, and Bach1, and the like.Type: ApplicationFiled: December 5, 2017Publication date: July 5, 2018Inventors: David Baltimore, Ryan M. O'Connell, Konstantin Taganov, Mark Boldin
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Patent number: 9862948Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1?, Sla, Cebp?, and Bach1, and the like.Type: GrantFiled: February 4, 2016Date of Patent: January 9, 2018Assignee: California Institute of TechnologyInventors: David Baltimore, Ryan M. O'Connell, Konstantin Taganov, Mark Boldin
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Publication number: 20160244754Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1?, Sla, Cepb?, and Bach1, and the like.Type: ApplicationFiled: February 4, 2016Publication date: August 25, 2016Inventors: David Baltimore, Ryan M. O'Connell, Konstantin Taganov, Mark Boldin
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Patent number: 9290761Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csflr, HIF1?, Sla, Cepb?, and Bach1, and the like.Type: GrantFiled: December 23, 2013Date of Patent: March 22, 2016Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: David Baltimore, Ryan M. O'Connell, Konstantin Taganov, Mark Boldin
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Patent number: 9090894Abstract: The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.Type: GrantFiled: December 17, 2008Date of Patent: July 28, 2015Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: David Baltimore, Mark Boldin, Konstantin Taganov
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Publication number: 20140220049Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csflr, HIFl?, Sla, Cepb?, and Bach1, and the like.Type: ApplicationFiled: December 23, 2013Publication date: August 7, 2014Applicant: California Institute of TechnologyInventors: David Baltimore, Ryan M. O'Connell, Konstantin Taganov, Mark Boldin
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Patent number: 8697672Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing and treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1?, Sla, Cepb?, and Bach1, and the like.Type: GrantFiled: May 16, 2008Date of Patent: April 15, 2014Assignee: California Institute of TechnologyInventors: David Baltimore, Ryan O'Connell, Konstantin Taganov, Mark Boldin
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Patent number: 8669235Abstract: The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.Type: GrantFiled: March 22, 2007Date of Patent: March 11, 2014Assignee: California Institute of TechnologyInventors: David Baltimore, Mark Boldin, Konstantin Taganov
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Patent number: 8236507Abstract: A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.Type: GrantFiled: February 3, 2009Date of Patent: August 7, 2012Assignee: Yeda Research and Development Co., Ltd.Inventors: David Wallach, Nikolai Malinin, Mark Boldin, Andrei Kovalenko, Igor Mett
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Publication number: 20110258716Abstract: The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.Type: ApplicationFiled: June 1, 2011Publication date: October 20, 2011Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: David Baltimore, Mark Boldin, Konstantin Taganov
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Patent number: 7799901Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors that interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided, as well as a method of designing them.Type: GrantFiled: September 18, 2006Date of Patent: September 21, 2010Assignee: Yeda Research and Development Co. Ltd.Inventors: David Wallach, Mark Boldin, Tanya Goncharov, Yury V. Golstev
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Publication number: 20090291888Abstract: A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.Type: ApplicationFiled: February 3, 2009Publication date: November 26, 2009Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: David Wallach, Nikolai Malinin, Mark Boldin, Andrei Kovalenko, Igor Mett
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Publication number: 20090203136Abstract: The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.Type: ApplicationFiled: December 17, 2008Publication date: August 13, 2009Inventors: David Baltimore, Mark Boldin, Konstantin Taganov
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Patent number: 7485456Abstract: A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.Type: GrantFiled: April 1, 1997Date of Patent: February 3, 2009Assignee: Yeda Research and Development Co. Ltd.Inventors: David Wallach, Nikolai Malinin, Mark Boldin, Andrei Kovalenko, Igor Mett
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Publication number: 20080300211Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing and treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1?, Sla, Cepb?, and Bach1, and the like.Type: ApplicationFiled: May 16, 2008Publication date: December 4, 2008Inventors: David Baltimore, Ryan O'Connell, Konstantin Taganov, Mark Boldin
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Patent number: 7323548Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.Type: GrantFiled: August 23, 2004Date of Patent: January 29, 2008Assignee: Yeda Research and Development Co. Ltd.Inventors: David Wallach, Mark Boldin, Eugene Varfolomeev, Igor Mett
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Publication number: 20070232553Abstract: The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.Type: ApplicationFiled: March 22, 2007Publication date: October 4, 2007Applicant: California Institute of TechnologyInventors: David Baltimore, Mark Boldin, Konstantin Taganov
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Publication number: 20070232520Abstract: The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.Type: ApplicationFiled: December 22, 2006Publication date: October 4, 2007Applicant: Yeda Research and Development Co., Ltd.Inventors: David WALLACH, Mark Boldin, Igor Mett, Eugene Varfolomeev
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Publication number: 20070166787Abstract: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.Type: ApplicationFiled: August 29, 2006Publication date: July 19, 2007Applicant: Yeda Research and Development Co. Ltd.Inventors: David Wallach, Mark Boldin, Eugene Varfolomeev, Zeev Pancer, Igor Mett, Tanya Goncharov