Abstract: Disclosed herein are tissue regeneration materials and methods of production and use thereof. Particles with a controlled structure that improves the tissue regeneration process by providing more space for tissue ingrowth are disclosed.

Abstract: Bone marrow aspirate harvesting is provided via use of a surgical device that includes a needle including a plurality of lateral holes defined at different positions longitudinally along a wall thereof and a movable aspiration insert within the needle, wherein the needle need not be repositioned within the patient to harvest bone marrow aspirate. The surgical device includes a needle with lateral holes; a movable aspiration insert including an aspiration window that is sized to interface with one lateral hole of the plurality of lateral holes at a time, wherein the aspiration insert is disposed in a lumen of the needle; and a handle including a positioning means in communication with the aspiration insert, wherein the positing means is configured to actuate between a first state and a second state to move the aspiration insert a certain distance in a first direction along a longitudinal axis of the needle.

Abstract: Auger-based bone harvesting and delivery may be provided by a surgical device comprising: a cannula having first and second openings disposed on respective first and second ends; an auger, disposed within the cannula, including a flighting arranged around an auger shaft (aligned concentrically to the cannula); and a holding area in communication with the first opening. Harvesting may be performed by rotating, a cutting tip against a bone to collect tissue; and conveying the tissue to a holding area via the auger (that is co-rotated with the cutting tip). Delivery may be performed by inserting the first opening of the cannula into a delivery site; providing a graft material in a holding area in communication with a second opening of the cannula into contact with the auger; rotating the auger to convey the graft material to the delivery site via the auger and cannula.

Abstract: Methods for treating cutaneous conditions and dermatoses such as disorders of the skin, subcutaneous tissues, mucous membranes, poorly vascularized tissues and/or other tissue disorders, including erosions, fissures, transient and/or chronic sores, burns, wounds, ulcers, lesions and infections. In particular embodiments, treatments include methods for improving skin and related tissue healing and repair using oxygen microbubbles (OMBs) and/or various formulations and/or compounds incorporating OMBs in combination with various other medicaments and/or tissue implants.

Abstract: Disclosed are improved devices, systems and methods of delivering oxygen and/or other therapeutic substances to a living organism, such as a mammal and/or human patient, by delivering and/or circulating microbubble carriers within existing anatomical passages of the organism that are accessible via external body orifices, such as portions of the organism's digestive and/or excretory tracts.

Abstract: Methods for treating cutaneous conditions and dermatoses such as disorders of the skin, subcutaneous tissues, mucous membranes, poorly vascularized tissues and/or other tissue disorders, including erosions, fissures, transient and/or chronic sores, burns, wounds, ulcers, lesions and infections. In particular embodiments, treatments include methods for improving skin and related tissue healing and repair using oxygen microbubbles (OMBs) and/or various formulations and/or compounds incorporating OMBs in combination with various other medicaments and/or tissue implants.

Abstract: Water-in-hydrocarbon emulsions, preferably comprising a fluorinated or perfluorinated hydrocarbon continuous phase, a discontinuous aqueous phase, and a surfactant or mixture of surfactants. The emulsions contain pharmacologically active agents, such as endothelin receptor antagonists, and are particularly suitable for pulmonary drug delivery. The emulsions are useful for treating pulmonary diseases or disorders, including pulmonary hypertension conditions, such as acute pulmonary arterial hypertension.

Abstract: Inflatable multi-chambered devices are provided for repairing or replacing spinal discs and distracting neighboring vertebral elements. Also included are cushioning devices that may be used in a joint replacement device cushioning system. Further included are kits and systems that include such devices, methods for making such devices, and methods of treating patients in need of such devices. Examples further include cosmetic augmentation and restoration devices.

Abstract: Inflatable multi-chambered devices are provided for repairing or replacing spinal discs and distracting neighboring vertebral elements. Also included are cushioning devices that may be used in a joint replacement device cushioning system. Further included are kits and systems that include such devices, methods for making such devices, and methods of treating patients in need of such devices. Examples further include cosmetic augmentation and restoration devices.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

Abstract: Inflatable multi-chambered devices are provided for repairing or replacing spinal discs and distracting neighboring vertebral elements. Also included are cushioning devices that may be used in a joint replacement device cushioning system. Further included are kits and systems that include such devices, methods for making such devices, and methods of treating patients in need of such devices. Examples further include cosmetic augmentation and restoration devices.

Abstract: Inflatable multi-chambered devices are provided for repairing or replacing spinal discs and distracting neighboring vertebral elements. Also included are cushioning devices that may be used in a joint replacement device cushioning system. Further included are kits and systems that include such devices, methods for making such devices, and methods of treating patients in need of such devices. Examples further include cosmetic augmentation and restoration devices.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

Abstract: Composite materials having improved mechanical properties and/or degradation profiles, devices and implants, kits including such implants, and methods of producing and using the same.

Abstract: The present invention provides novel methods of forming mineralized gelatin carriers from bone. The present invention further provides mineralized gelatin carriers themselves; bone products that include such mineralized gelatin carriers including DBM bone products; and kits that include mineralized gelatin carriers formed from bone. The present invention further provides methods for making DBM bone products, wherein both the DBM and a mineralized gelatin carrier for the DBM are derived independently from a bone lot.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.