Abstract: In an example of the method, a functionalized coating layer is applied in depressions of a patterned flow cell substrate. The depressions are separated by interstitial regions. A primer is grafted to the functionalized coating layer to form a grafted functionalized coating layer in the depressions. A hydrogel is applied on at least the grafted functionalized coating layer.

Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device can be a wearable automatic injector configured to be worn on the patient's skin. The delivery device of the present disclosure may allow a user or the patient to view a status of a container. For example, the delivery device of the present disclosure may provide a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device can be a wearable automatic injector configured to be worn on the patient's skin. The delivery device of the present disclosure may allow a user or the patient to view a status of a container. For example, the delivery device of the present disclosure may provide a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: A container (10) for storing new and used pen needles (20,30), the container (10) comprising a housing (12) including a first compartment (50) configured to store one or mom new pen needles (20), and a second compartment (52) configured to store one or more used pen needles (30), wherein the first and second compartments (50,52) are inversely adjustable in size to accommodate various combinations of new and used pen needles (20, 30).

Abstract: A rotary machine seal assembly (200) includes seal segments (102) configured to circumferentially extend around a rotor (108) between a stator (106) and the rotor (108) of a rotary machine. One or more seal segments include a shoe plate (110, 410, 710, 910), a seal base (112, 412, 712, 912), and at least one intermediate member (114, 414, 714). The shoe plate is disposed along the rotor. The seal base is disposed radially outward of the shoe plate. At least one intermediate member is coupled to and disposed between the seal base and the shoe plate. The at least one intermediate member includes an actuator portion (302, 402, 702, 902) having first coefficient of thermal expansion and a constrictor portion (304, 404, 704, 904) having a different, second coefficient of thermal expansion.

Abstract: A safety pen needle assembly (12) is disclosed which comprises a hub (30), a needle cannula (20) engaged to the hub (30), the needle cannula (20) having a distal end for insertion into a patient, and a proximal end extending into the hub (30), a sleeve (14) surrounding the hub (30) and needle cannula (20), a shield (16) including a window (18), the shield (16) surrounding the sleeve (14) and movable relative to the sleeve (14) from a first position, to a second position and to a third position to expose and cover the distal end of the needle cannula (20), and a spring (144) urging the shield (16) to move relative to the sleeve (14) from the second position to the third position, wherein the window (18) indicates when the needle cannula (20) is extended in the second position.

Abstract: A needle hub assembly for a pen needle includes a needle hub, an inner shield and an outer cover. The open end of the outer cover is closed by a removable seal to access the needle hub. The needle hub has a body with a shoulder and a tower extending from the body for supporting a cannula. The inner shield fits over the tower and the cannula and includes a flange that has an outer dimension complementing the outer dimension of the needle hub and contacts the shoulder of the needle hub in the assembled condition. The outer cover encloses the needle hub and the inner shield and includes a stop member on an inner surface that contacts the flange of the inner shield to capture the inner shield between the shoulder of the needle hub and the outer cover.

Abstract: A needle hub assembly for a pen needle includes a needle hub, an inner shield and an outer cover. The open end of the outer cover is closed by a removable seal to access the needle hub. The needle hub has a body with a shoulder and a tower extending from the body for supporting a cannula. The inner shield fits over the tower and the cannula and includes a flange that has an outer dimension complementing the outer dimension of the needle hub and contacts the shoulder of the needle hub in the assembled condition. The outer cover encloses the needle hub and the inner shield and includes a stop member on an inner surface that contacts the flange of the inner shield to capture the inner shield between the shoulder of the needle hub and the outer cover.

Abstract: A needle hub assembly for a pen needle includes a needle hub, an inner shield and an outer cover. The open end of the outer cover is closed by a removable seal to access the needle hub. The needle hub has a body with a shoulder and a tower extending from the body for supporting a cannula. The inner shield fits over the tower and the cannula and includes a flange that has an outer dimension complementing the outer dimension of the needle hub and contacts the shoulder of the needle hub in the assembled condition. The outer cover encloses the needle hub and the inner shield and includes a stop member on an inner surface that contacts the flange of the inner shield to capture the inner shield between the shoulder of the needle hub and the outer cover.

Abstract: A container (10) for storing new and used pen needles (20,30), the container (10) comprising a housing (12) including a first compartment (50) configured to store one or mom new pen needles (20), and a second compartment (52) configured to store one or more used pen needles (30), wherein the first and second compartments (50,52) are inversely adjustable in size to accommodate various combinations of new and used pen needles (20, 30).

Abstract: A syringe assembly includes a syringe barrel (12) having a proximal end and a distal end, a needle hub (20) supporting the needle and coupled to the distal end of the syringe barrel (12). A connecting member (46, 102, 156) is positioned on the syringe barrel for sliding between a first position where the needle is exposed and a second position covering at least a portion of the needle. The connecting member (46, 102, 156) is configured for connecting to a container (50) and supporting the container when said needle is advanced to pierce a septum (90) in said container. In another embodiment, a syringe assembly includes a syringe barrel and an adapter (222, 282, 322) coupled to the distal end of the syringe barrel (12). The adapter (222, 282, 322) is movable between a first position to expose a first portion of the needle (22) having a first length, and a second position to cover the distal end of the syringe barrel to expose a second portion of the needle having a second length.

Abstract: A safety pen needle assembly (12) is disclosed which comprises a hub (30), a needle cannula (20) engaged to the hub (30), the needle cannula (20) having a distal end for insertion into a patient, and a proximal end extending into the hub (30), a sleeve (14) surrounding the hub (30) and needle cannula (20), a shield (16) including a window (18), the shield (16) surrounding the sleeve (14) and movable relative to the sleeve (14) from a first position, to a second position and to a third position to expose and cover the distal end of the needle cannula (20), and a spring (144) urging the shield (16) to move relative to the sleeve (14) from the second position to the third position, wherein the window (18) indicates when the needle cannula (20) is extended in the second position.

Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device is a wearable automatic injector configured to be worn on the patient's skin. A delivery device of the present disclosure allows a user or patient to view the status of a container. For example, a delivery device of the present disclosure provides a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: Methods and apparatus for maintaining a sanitary disposal and storage bin for consumed medical products using a storage bin with a liner bag and an attached shielding grommet in the shape of a circle flattened on one end which, when soiled, may itself be placed in the liner bag within the container.

Abstract: Methods and apparatus for maintaining a sanitary disposal and storage bin for consumed medical products using a storage bin with a liner bag and an attached shielding grommet in the shape of a circle flattened on one end which, when soiled, may itself be placed in the liner bag within the container.