Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Control methods are disclosed for continuous, unmodulated, multiple catalytic conversion step processes using at least two catalysts, a first catalyst and a second catalyst, that accommodate changes in the performance of each catalyst and the relative performances of the catalysts. In the methods, certain process parameters are used in a manner that is indicative of changes in catalyst performance, and the control methods provide for adjustment of at least one of: the absolute amount of catalytically active species and relative amounts of each of the first catalyst and second catalyst and at least one of the rate of feed or concentration of the raw material to the reaction zone.

Abstract: In some embodiments, an electric field generator includes a differential oscillator that oscillates at a nominal frequency. The electric field generator is connected to a differential antenna that radiates an electric field. A differential detector measures a frequency of the generated electric field as the electric field interacts with a body (such as a human body) in a reactive near-field region of the electric field. For each of one or more internal components of the body, a computation unit determines a respective periodic behavior in the measured frequency indicative of movement of the internal component. The computation unit also computes, for each of the one or more internal components of the body, a respective rate of movement (such as a heart rate or a respiration rate) of the internal component according to the respective periodic behavior in the measured frequency.

Abstract: In some embodiments, an electric field generator generates an electric field at a nominal frequency and a nominal amplitude. The electric field generator is connected to an antenna that radiates the electric field. A detector measures a frequency and an amplitude of the generated electric field as the electric field interacts with a body (such as a human body) in a reactive near-field region of the electric field. For each of one or more internal components of the body, a computation unit determines a respective periodic behavior in the measured frequency corresponding to movement of the internal component. The computation unit also computes, for each of the one or more internal components, a respective rate of the movement of the internal component based on the determined respective periodic behavior in the measured frequency. A gain control circuit adjusts the nominal amplitude according to the measured amplitude.

Abstract: In some embodiments, an electric field generator generates an electric field at a nominal frequency. A detector measures, at multiple time points during a measuring period, one or more properties of the generated electric field. In various embodiments, the one or more properties of the electric field change over time due to interactions with a human body in a reactive near-field region of the electric field. From the measured one or more properties, a computation unit determines one or more periodic behaviors (such as a respiration or heartbeat) and one or more non-periodic behaviors (such as movement of a limb). The computation unit also computes, from at least one of the periodic and non-periodic behaviors, one or more physiological parameters of the human body. From the one or more physiological parameters, the computation unit detects one or more symptoms of a condition of the human body.

Abstract: The present technology is directed to a remotely controlled aircraft that can be transported without the risk of damaging certain components, such as the arms and/or propellers. In one non-limiting example, the remotely controlled aircraft technology described herein provides a housing that allows the arms of the remotely controlled aircraft to extend and/or retract through openings in the housing. When retracted, the arms and propellers are protected within an area of the structure of the housing, and when extended, the arms and propellers are operable to make the remotely controlled aircraft fly.

Abstract: The present technology is directed to a remotely controlled aircraft that can be transported without the risk of damaging certain components, such as the arms and/or propellers. In one non-limiting example, the remotely controlled aircraft technology described herein provides a housing that allows the arms of the remotely controlled aircraft to extend and/or retract through openings in the housing. When retracted, the arms and propellers are protected within an area of the structure of the housing, and when extended, the arms and propellers are operable to make the remotely controlled aircraft fly.

Abstract: The present technology is directed to a remotely controlled aircraft that can be transported without the risk of damaging certain components, such as the arms and/or propellers. In one non-limiting example, the remotely controlled aircraft technology described herein provides a housing that allows the arms of the remotely controlled aircraft to extend and/or retract through openings in the housing. When retracted, the arms and propellers are protected within an area of the structure of the housing, and when extended, the arms and propellers are operable to make the remotely controlled aircraft fly.

Abstract: The present technology is directed to a remotely controlled aircraft that can be transported without the risk of damaging certain components, such as the arms and/or propellers. In one non-limiting example, the remotely controlled aircraft technology described herein provides a housing that allows the arms of the remotely controlled aircraft to extend and/or retract through openings in the housing. When retracted, the arms and propellers are protected within an area of the structure of the housing, and when extended, the arms and propellers are operable to make the remotely controlled aircraft fly.

Abstract: The present technology is directed to a remotely controlled aircraft that can be transported without the risk of damaging certain components, such as the arms and/or propellers. In one non-limiting example, the remotely controlled aircraft technology described herein provides a housing that allows the arms of the remotely controlled aircraft to extend and/or retract through openings in the housing. When retracted, the arms and propellers are protected within an area of the structure of the housing, and when extended, the arms and propellers are operable to make the remotely controlled aircraft fly.

Abstract: This disclosure provides systems, methods and apparatus for reducing capacitance between interconnects in a display apparatus. In one aspect, a display apparatus can include a plurality of light modulators each having a shutter suspended over a substrate. A first suspended interconnect can electrically couple a first light modulator and a second light modulator. A majority of the length of the first suspended interconnect can be suspended a first height above the substrate. A second suspended interconnect can electrically couple the first light modulator and a third light modulator. A majority of the length of the second suspended interconnect can be above the substrate at a different height than the first suspended interconnect.

Abstract: A novel plate heat exchanger opening and closing fixture having at least two hydraulic linear actuators located between a set of plates each having an opening to receive a plate heat exchanger threaded rod, whereby, the hydraulic opening and closing tool is secured to the threaded rod by a novel slip-on lock nut having at least one handle so an operator can rotate the slip-on lock nut without the need of a wrench. When the plates are hydraulically compressed clearance between the frame plate and the adjacent threaded rods having a slip-on lock nut with at least one handle are created. This clearance allows the slip-on lock nut having at least one handle to be more easily removed from an adjacent threaded rod.

Abstract: A communication system includes a voice-directed portable terminal with a voice user interface that is configured for being able to communicate with a computer system. The communication system includes a peripheral device having a cord coupled with the portable terminal and a connector adapted to disconnect from the portable terminal when a sufficient force is applied to the cord. This disengages the peripheral device from the portable terminal. The ability of the cord to break-away from the portable terminal prevents damage not only to the connector, but also to the cord, peripheral, and terminal.

Abstract: An apparatus for interfacing a test head to a peripheral system is provided. The apparatus includes a first unit having a first connection member for providing electrical communication with the peripheral system, a second unit having a second connection member for providing electrical communication with the test system, and pivot members coupling the first unit and the second unit. The pivot members enable motion in the following sequence as one of the first and second unit moves towards the other: a) pivotal motion between the first connection member and the second connection member; and b) linear motion which decreases linear distance between the first connection member and the second connection member while maintaining respective contact surfaces of the first and second connection members in parallel.

Abstract: An apparatus for interfacing a test head to a peripheral system is provided. The apparatus includes a first unit having a first connection member for providing electrical communication with the peripheral system, a second unit having a second connection member for providing electrical communication with the test system, and pivot members coupling the first unit and the second unit. The pivot members enable motion in the following sequence as one of the first and second unit moves towards the other: a) pivotal motion between the first connection member and the second connection member; and b) linear motion which decreases linear distance between the first connection member and the second connection member while maintaining respective contact surfaces of the first and second connection members in parallel.

Abstract: An apparatus for interfacing a test head to a peripheral system is provided. The apparatus includes a first unit having a first connection member for providing electrical communication with the peripheral system, a second unit having a second connection member for providing electrical communication with the test system, and pivot members coupling the first unit and the second unit. The pivot members enable motion in the following sequence as one of the first and second unit moves towards the other: a) pivotal motion between the first connection member and the second connection member; and b) linear motion which decreases linear distance between the first connection member and the second connection member while maintaining respective contact surfaces of the first and second connection members in parallel.

Abstract: A method of providing a credit to a customer of a resort or casino for use with goods or services sold by the resort or casino while allowing the customer to retain his privacy concerning the consumption of the particular resort or casino goods or services with which the credit is utilized.