Patents by Inventor Mark Brantly

Mark Brantly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Increased expression of .alpha.-1-antitrypsin in expression vectors through the inclusion of intron II
    Patent number: 5439824
    Abstract: The present invention relates to novel expression vectors and a method to increase the expression of .alpha..sub.1 -antitrypsin (AAT) from expression vectors encoding for the same through the inclusion of the Intron II sequence. Preferably, the Intron II sequence is included in its naturally occurring position, immediately after Exon II. Also, the invention is methods of therapy using the method and the expression vectors.
    Type: Grant
    Filed: May 6, 1993
    Date of Patent: August 8, 1995
    Assignee: The United States of America
    Inventors: Mark Brantly, Victor Laubach