Abstract: Systems and methods are provided for multi-space vehicle charging. An example system may include a cord management system configured to extend across a plurality of parking spaces and configured to move a charging connector of a cord to at least one selected parking space of the plurality of parking spaces associated with at least one vehicle. The cord may extend from a charging device. An example method may include receiving a request to charge a vehicle located in a parking space of a plurality of parking spaces and/or moving a charging connector of a cord extending from a charging device to the parking space of the vehicle.

Abstract: According to the invention there is a method of applying a catalyst layer to a surface, the method comprising the steps of: providing a donor substrate having opposing first and second surfaces and providing a catalyst ink disposed as a layer on the second surface, wherein the catalyst ink comprises a catalyst and a solvent; providing an acceptor substrate, wherein the second surface of the donor substrate faces towards the acceptor substrate; and irradiating the catalyst ink with laser radiation at a wavelength which is absorbed by the catalyst ink so as to transfer the catalyst ink from the donor substrate to the acceptor substrate.

Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.

Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.

Abstract: An apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.

Abstract: Disclosed herein are embodiments of method for detecting degradation of a connecting rod big end bearing within an internal combustion engine including a crankshaft and an exhaust manifold included on a vehicle. A method includes providing an electronic control unit connected with the engine, a first set of sensors for detecting crankshaft acceleration connected located adjacent the crankshaft, a second set of sensors for detecting engine exhaust manifold pressure located adjacent the engine exhaust manifold, and a display component and an auditory component connected with the electronic control unit. The display component and/or the auditory component is activated when the first set of sensors detects diminished crankshaft acceleration during a power stroke compared to prior acceleration of the crankshaft during a power stroke and the second set of sensors detects exhaust manifold pressure that does not vary statistically significantly from expected exhaust manifold pressure.

Abstract: Disclosed herein are embodiments of method for detecting degradation of a connecting rod big end bearing within an internal combustion engine including a crankshaft and an exhaust manifold included on a vehicle. A method includes providing an electronic control unit connected with the engine, a first set of sensors for detecting crankshaft acceleration connected located adjacent the crankshaft, a second set of sensors for detecting engine exhaust manifold pressure located adjacent the engine exhaust manifold, and a display component and an auditory component connected with the electronic control unit. The display component and/or the auditory component is activated when the first set of sensors detects diminished crankshaft acceleration during a power stroke compared to prior acceleration of the crankshaft during a power stroke and the second set of sensors detects exhaust manifold pressure that does not vary statistically significantly from expected exhaust manifold pressure.

Abstract: The present invention relates to compounds for stabilising the native tetrameric form of transthyretin and protecting it from proteolytic cleavage; compounds for use in the prevention and treatment of transthyretin amyloidosis; and agents and medicaments comprising such compounds. The compounds are based on a general structure A-L-B, wherein A is a group of formula (II) or of formula (III): or of formula (IV) or of formula (V) B is a group of formula (III), (IV), or (V), or a group of formula (VI) or a group of formula —R10Z, wherein: Z is selected from —CO2R?, —CONR?R?, —SO2R? wherein R? and R? are independently H or C1-C4 alkyl; and R10 is a C1-C4 alkylene or alkenylene group; and L represents a linker group which is a saturated or unsaturated chain of 5 to 13 carbon atoms.

Abstract: Methods of operating a water heater appliance are provided. The water heater appliance includes a tank, a cold water inlet conduit extending into the tank, a heating element within the tank, a hot water conduit extending from the tank to a mixing valve, a mixed water conduit downstream of the mixing valve, and a user interface. The method includes receiving a user input, determining a tank temperature setpoint value based on the received user input, and adjusting a tank temperature setpoint to the determined tank temperature setpoint value.

Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.

Abstract: An audio navigation device comprising an input means for inputting two or more audio pieces into the navigation device; a spatialization means for allocating a position in the form of a unique spatial coordinate to each audio piece and arranging the audio pieces in a multi-dimensional arrangement; a generating means for generating a binaural audio output for each audio piece, wherein the audio output simulates sounds that would be made by one or more physical sources located at the given position of each audio piece; an output means for simultaneously outputting multiple audio pieces as binaural audio output to a user; a navigation means for enabling a user to navigate around the audio outputs in the multi-dimensional arrangement; and a selection means for allowing a user to select a single audio output.

Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.

Abstract: The invention comprises an agent for use in medicine, wherein the agent comprises a compound of Formula (I): B-L-B? wherein: B and B? are independently selected from groups of formula (B-I) wherein: Z is selected from —COOH, —CH2COOH, —PO(OH)(OR1), or —CH2PO(OH) (OR1), wherein R1 is H or a phosphate protecting group; W is an alicyclic amine group having from 5 to 12 carbon atoms and at least one amine nitrogen atom; W? is H, or W? is linked to W to form said alicyclic amine group; and Y is selected from —NH—, —N(CH3)—, —CH2—, —NHCO—, —CH2CONH—, —CONH—, CH2NHCO—, or —NHCH2—; and L is a linker group.

Abstract: An agent for use in medicine, wherein the agent comprises a compound of Formula (I): wherein Ar is an aryl linker group, for example a 1,4-phenyl group, including individual pharmaceutically acceptable salts, solvates, prodrugs or derivatives thereof. The compounds of Formula (I) are inhibitors of human C-reactive protein (CRP) and may be used for the treatment of medical conditions mediated by CRP. Also provided are methods of making the compounds of Formula (I) and chemical intermediates thereof.

Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.

Abstract: A child restraint system includes a shell including an aperture formed therein. The child restraint system further includes a head support member disposed with at least a portion of the shell. The child restraint system further includes a bumper configured to extend through the aperture and contact a part of the head support member when a force is applied to the bumper.

Abstract: A child restraint system includes a shell including an aperture formed therein. The child restraint system further includes a head support member disposed with at least a portion of the shell. The child restraint system further includes a bumper configured to extend through the aperture and contact a part of the head support member when a force is applied to the bumper.

Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.

Abstract: Devices, systems, methods, and articles of manufacture for delivering disinfecting electromagnetic radiation to various areas, items, and components of a cabin of an aircraft are provided herein. For example, the disclosed disinfecting system may be configured to emit electromagnetic radiation to disinfect a stowable item, such as a personal item of a passenger or a component of the aircraft cabin. Generally, the devices, systems, methods, and articles of manufacture disclosed and described herein facilitate disinfection treatments, especially to items and/or components that would not be subjected to conventional aircraft cleaning treatments.

Abstract: The pose or position and orientation of a wearable sensor assembly in a reference coordinate system are to be determined in real-time. One or more artificial magnetic field sources are located with known positions and orientations in the reference coordinates. Each source generates a magnetic field which varies in time according to a predetermined AC pulse code, so that each source is uniquely identifiable and distinguishable from ambient DC fields. The magnitude and direction in wearable coordinates of the AC magnetic field due to each source varies in a modelable way with position and orientation of the wearable, which comprises a nine-channel Inertial Measurement Unit (IMU) and a processor. The IMU senses the inertial motion of the wearable and the time-varying magnetic field to which it's exposed. These data are processed to estimate the position and orientation of the wearable in reference coordinates, along with various constant parameters.