Patents by Inventor Mark Browne

Mark Browne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11718817
    Abstract: Devices and methods for the efficient disaggregation of tissue samples, separating the tissue into individual intact cells or small aggregates of cells for analysis. A device may include a chamber to receive fluid and a tissue specimen containing more than one cell to be disaggregated. The chamber may include an opening and an agitator in fluid contact with the fluid and the tissue specimen. The agitator may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The device may include an electrical energy source electrically coupled to the micromotor to rotate the impeller sufficient to disaggregate the one or more individual cells from the tissue specimen and in a manner which does not lyse the one or more individual cells.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: August 8, 2023
    Assignee: CLAREMONT BIOSOLUTIONS LLC
    Inventors: Mark Brown, Robert Doebler, Gary Fife Blackburn
  • Patent number: 11707396
    Abstract: An apparatus for mounting and securing medical/surgical devices may be attached to a litter (40), The medical/surgical devices may include. for example, IV holders (186), aspirators (144). cardiac monitors (148) , defibrillators (150) , infusion pumps 152 (152), ventilators (146) and other devices. The apparatus frame assembly (10) includes rails (12), (14), (16), (18), (20), (46), (48), (50), (52) having cross-sections of standard surgical rails, for attachment of slidable rail clamps (84), (104). Medical device mounts (108), (110), (112) are attached to the slidable rail clamps. The medical device mounts have height and/or rotational adjustment to improve patient access and view. The apparatus may be mounted longitudinally anywhere along the litter to maximize access to the patient.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: July 25, 2023
    Assignee: The Government of the United States, as Represented by the Secretary of the Army
    Inventors: Mark Brown, Scott Walters, Mark Easterday, Jay Bartlett, Jaime Lee
  • Patent number: 11699583
    Abstract: An ion source is provided comprising a nebuliser or electrospray probe (1) for nebulising a sample and an impact surface or target electrode (5). The impact surface or target electrode (5) comprises a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Also provided is an ion source comprising a nebuliser or electrospray probe with a central wire comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Adducts with relatively heavy metals result in simplified multiply-charged mass spectra that are easier to interpret.
    Type: Grant
    Filed: July 4, 2019
    Date of Patent: July 11, 2023
    Assignee: Micromass UK Limited
    Inventors: Stevan Bajic, Jeffery Mark Brown
  • Patent number: 11697688
    Abstract: The present disclosure provides antibody sequences found in antibodies that bind to human CD25, in particular an anti CD25-a-674 antibody which do not block the binding of CD25 to IL-2 or IL-2 signalling. The claimed antibody binds to the epitopes: QCVQGYRA and RWTQPQLICTG on CD25 Antibodies and antigen-binding portions thereof including such sequences can be used in pharmaceutical compositions and methods of treatment, in particular for treating cancer.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: July 11, 2023
    Assignees: Tusk Therapeutics Ltd., Cancer Research Technology Limited
    Inventors: Anne Goubier, Beatriz Goyenechea Corzo, Josephine Salimu, Kevin Moulder, Pascal Merchiers, Mark Brown, James Geoghegan, Bianka Prinz, Sergio Quezada
  • Patent number: 11688598
    Abstract: A method of producing ions from a sample is disclosed. The method comprises directing a spray of droplets onto a sample, and causing droplets comprising analyte from the sample to impact upon a surface so as to generate analyte ions.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: June 27, 2023
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Steven Derek Pringle, Jeffery Mark Brown
  • Publication number: 20230113996
    Abstract: Flange for a vacuum apparatus comprises a housing to be connected to the vacuum apparatus defining an opening wherein the opening has rectangular narrow shape. The flange further comprises a metal seal arranged around the opening to create a vacuum tight seal.
    Type: Application
    Filed: February 18, 2021
    Publication date: April 13, 2023
    Inventors: Douglas Mark Brown, Marcus Hans Robert Thierley
  • Publication number: 20230075989
    Abstract: A seal for a dock levelling system including a movable hinged ramp arranged within a recess. The seal is for sealing a horizontal gap between the hinged end of the movable ramp and a wall of the recess, and includes a rod and a tube of flexible material surrounding the rod.
    Type: Application
    Filed: January 20, 2021
    Publication date: March 9, 2023
    Applicant: RENTOKIL INITIAL 1927 PLC
    Inventor: Mark Brown
  • Publication number: 20230069784
    Abstract: An apparatus for mounting and securing medical/surgical devices may be attached to a litter 40. The medical/surgical devices may include, for example, IV holders 186, aspirators 144, cardiac monitors 148, defibrillators 150, infusion pumps 152, ventilators 146 and other devices. The apparatus frame assembly 10 includes rails 12, 14, 16, 18, 20, 46, 48, 50, 52 having cross-sections of standard surgical rails, for attachment of slidable rail clamps 84, 104. Medical device mounts 108, 110, 112 are attached to the slidable rail clamps. The medical device mounts have height and/or rotational adjustment to improve patient access and view. The apparatus may be mounted longitudinally anywhere along the litter to maximize access to the patient.
    Type: Application
    Filed: March 3, 2021
    Publication date: March 2, 2023
    Applicant: THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Mark Brown, Scott Walters, Mark Easterday, Jay Bartlett, Jaime Lee
  • Publication number: 20230059666
    Abstract: A seal for a dock levelling system including a movable ramp arranged within a recess. The seal is for sealing a gap between a side of the movable ramp and a wall of the recess, and including a flexible strip formed of a flexible material, and on each longitudinal edge of the flexible strip, an attachment strip for attaching the flexible strip to the side of the movable ramp. The seal is arranged so that when the attachment strips are attached adjacently to each other to the side of the movable ramp, the material of the flexible strip between the attachment strips forms a closed loop extending out from the side of the movable ramp to the wall of the recess, to seal the gap between the side of the movable ramp and the wall of the recess.
    Type: Application
    Filed: January 20, 2021
    Publication date: February 23, 2023
    Applicant: RENTOKIL INITIAL 1927 PLC
    Inventors: Gary Wingett, Mark Brown, Robert Shand
  • Publication number: 20230042117
    Abstract: Devices and methods for the efficient disaggregation of tissue samples, separating the tissue into individual intact cells or small aggregates of cells for analysis. A device may include a chamber to receive fluid and a tissue specimen containing more than one cell to be disaggregated. The chamber may include an opening and an agitator in fluid contact with the fluid and the tissue specimen. The agitator may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The device may include an electrical energy source electrically coupled to the micromotor to rotate the impeller sufficient to disaggregate the one or more individual cells from the tissue specimen and in a manner which does not lyse the one or more individual cells.
    Type: Application
    Filed: March 28, 2022
    Publication date: February 9, 2023
    Inventors: Mark Brown, Robert Doebler, Gary Fife Blackburn
  • Patent number: 11567087
    Abstract: A method of ionising a sample is disclosed comprising nebulising a sample which includes monoclonal antibody (“mAb”) molecules. A stream of monoclonal antibody droplets or charged droplets is directed so as to impact upon a target or electrode so as to form intact parent monoclonal antibody ions, intact minus light chain parent monoclonal antibody ions or light chain (“LC”) fragment monoclonal antibody ions.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: January 31, 2023
    Assignee: Micromass UK Limited
    Inventors: Steven Bajic, Jeffrey Mark Brown
  • Publication number: 20220359177
    Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.
    Type: Application
    Filed: May 16, 2022
    Publication date: November 10, 2022
    Applicant: Micromass UK Limited
    Inventors: Keith Richardson, Jeffery Mark Brown, David J. Langridge
  • Patent number: 11485648
    Abstract: The present invention provides a method of managing operation of a point-of-use fluid treatment arrangement for providing treated fluid to at least one end user. The point-of-use fluid treatment arrangement comprises a fluid supply source provided by an operator, at least one fluid outlet for providing fluid to an end user, in which the at least one fluid outlet is in fluid communication with and spaced downstream from a point of supply of the fluid supply source, at least one point-of-use or point-of-entry fluid treatment device located at or adjacent a corresponding fluid outlet, and at least one communication unit.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: November 1, 2022
    Assignee: Datumpin, Inc.
    Inventors: Philip Colin Chandler, Darren Mark Brown, Michael Sean Finney
  • Patent number: 11479747
    Abstract: Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: October 25, 2022
    Assignee: CLAREMONT BIOSOLUTIONS LLC
    Inventors: Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling
  • Publication number: 20220337639
    Abstract: Examples can include a system for video chat cycles within a social media application. An organizer platform can be used to design a schedule for the video chat cycles. This can include scheduled organizer content before, after, and between video chats. The organizer content can include graphics, video, and even live streams by the organizer.
    Type: Application
    Filed: April 19, 2022
    Publication date: October 20, 2022
    Inventors: Jeff Emile, Mark Brown
  • Publication number: 20220261927
    Abstract: Examples can include a system for video chat cycles within a social media application. The application can pair users for video chats in a dating cycle where multiple users perform multiple chats in succession. The pairing can be based on common interests that can be predetermined based on likes and posts within a feed. Artificial intelligence bots can also participate in the dating cycles when another matching user is unavailable. Additionally, a last looks screen can allow the user to adjust their appearance and can provide options based on interests of other users likely to be paired with the user in the dating cycle.
    Type: Application
    Filed: February 14, 2022
    Publication date: August 18, 2022
    Inventors: Jeff Emile, Mark Brown
  • Patent number: 11402385
    Abstract: A method of mass spectrometry determines if a mutated variant of a target protein is present in a sample. The method includes subjecting the sample to fragmentation so as to cause the target protein to fragment to form second generation fragment ions, and then mass analysing these fragment ions to obtain spectral data. The method determines if a mutated variant is present in the sample by determining that an ion in the spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if the target protein was a normal unmutated version of the target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of the target protein.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 2, 2022
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Michael Raymond Morris, Jonathan Williams, Brian Green
  • Patent number: 11367602
    Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 21, 2022
    Assignee: Micromass UK Limited
    Inventors: Keith Richardson, Jeffery Mark Brown, David J. Langridge
  • Patent number: 11342175
    Abstract: A mass spectrometer comprising: a multi-reflecting time of flight (MRTOF) mass analyser or mass separator having two gridless ion mirrors 2 that are elongated in a first dimension (Z-dimension) and configured to reflect ions multiple times in a second orthogonal dimension (X-dimension) as the ions travel in the first dimension; the spectrometer configured to operate in: (i) a first mode for ions having a first rate of interaction with background gas molecules in the mass analyser or separator, such that the ions are reflected a first number of times between the ion mirrors 2; and (ii) a second mode for ions having a second, higher rate of interaction with background gas molecules in the mass analyser or separator, such that ions are reflected a second, lower number of times between the ion mirrors 2.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: May 24, 2022
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Boris Kozlov
  • Patent number: 11328917
    Abstract: A MALDI ion source is disclosed comprising: a target plate (2) having a front surface (4), a rear surface (6), and at least one sample receiving well (9) for receiving a liquid sample or at least one sample receiving channel (8) extending from an opening (12) in the rear surface (6) to an opening (14) in the front surface (4) for receiving a liquid sample (10), wherein each well (9) or channel (8) has a volume of ?1 ?L. The ion source also comprise a laser (16) for ionising a liquid sample (10) on or in the target plate (2), wherein the laser (16) is a pulsed laser set up and configured to have a pulsed repetition rate of ?20 Hz, or is a continuous laser.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: May 10, 2022
    Assignee: Micromass UK Limited
    Inventor: Jeffery Mark Brown