Abstract: Livestock animals and progeny thereof comprising at least one modified chromosomal sequence that reduces expression or activity of a Transmembrane Serine Protease 2 (TMPRSS2) protein and/or a Transmembrane Serine Protease 4 (TMPRSS4) protein are provided. Livestock animal cells that contain such edited chromosomal sequences are also provided. The livestock animals, progeny, and cells have increased resistance to influenza viruses and coronaviruses. Methods for producing influenza resistant and porcine epidemic diarrhea resistant livestock animals are also provided.

Abstract: Disclosed are gene edited ungulate animals and methods of editing genes that control various ungulate traits. Such methods include CRISPR, zinc fingers, or TALENS. Exemplary traits for editing include polled, sterility or fertility, milk production, growth (which increases meat production), fat production, conception rates, stillborn rates, calving ease, or content of produced milk such as the amount of protein or the amount of fat. Other traits include backfat thickness, intramuscular fat, ultrasound loin muscle area, loin muscle area and intramuscular fat content, chest circumference, withers height, body length, hip height, rump length, and heart girth. Other exemplary native traits include, but are not limited to, high altitude adaptation and response to hypoxia, cold acclimation, body size and stature, resistance to disease and bacterial infection, reproduction, milk yield and components, and feed efficiency.

Abstract: An exemplary prefabricated offset shingle includes a headlap portion extending from a top edge to a nail zone, a tab portion extending from the nail zone to a bottom edge, the headlap portion and the tab portion extending between first and second side edges. Two transverse cuts extend from the bottom edge to the headlap portion, and frangible lines of weakness in line with the transverse cuts extend from the transverse cuts to the top edge. The cuts and lines of weakness separate the shingle into first, second, and third offset portions having first, second, and third widths.

Abstract: An exemplary prefabricated offset shingle includes a headlap portion extending from a top edge to a nail zone, a tab portion extending from the nail zone to a bottom edge, the headlap portion and the tab portion extending between first and second side edges. Two transverse cuts extend from the bottom edge to the headlap portion, and frangible lines of weakness in line with the transverse cuts extend from the transverse cuts to the top edge. The cuts and lines of weakness separate the shingle into first, second, and third offset portions having first, second, and third widths.

Abstract: An exemplary prefabricated offset shingle includes a headlap portion extending from a top edge to a nail zone, a tab portion extending from the nail zone to a bottom edge, the headlap portion and the tab portion extending between first and second side edges. Two transverse cuts extend from the bottom edge to the headlap portion, and frangible lines of weakness in line with the transverse cuts extend from the transverse cuts to the top edge. The cuts and lines of weakness separate the shingle into first, second, and third offset portions having first, second, and third widths.