Abstract: Provided herein, inter alia, are methods and compounds for treating an HIV infection.

Abstract: Provided herein, inter alia, are methods and compounds for treating an HIV infection.

Abstract: 15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.

Abstract: Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.

Abstract: 15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.

Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

Abstract: Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.

Abstract: The invention comprises a staple gun with highly compact accessory apparatus for attaching a planar tab or label to a fixing surface. The accessory has a housing and a positioning and indexing assembly associated with the housing which is operable to feed and hold a tab or label between the staple gun head and fixing surface, thereby allowing single-handed fixing of a label or tab to a fixing surface. The apparatus can include a roller assembly, staple gun and accessory apparatus or have all components integrated into the construction of a staple gun apparatus. Preferably, the apparatus is mated with a tab or label holding magazine. Some exemplary embodiments of the invention are suitable for securing protective covering to lumber product and may be configured for rectangular polyolefin tabs measuring approximately 0.035 inch thick and 1.0 inches by 2.0 inches.

Abstract: Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

Abstract: The invention comprises a staple gun with highly compact accessory apparatus for attaching a planar tab or label to a fixing surface. The accessory has a housing and a positioning and indexing assembly associated with the housing which is operable to feed and hold a tab or label between the staple gun head and fixing surface, thereby allowing single-handed fixing of a label or tab to a fixing surface. The apparatus can include a roller assembly, staple gun and accessory apparatus or have all components integrated into the construction of a staple gun apparatus. Preferably, the apparatus is mated with a tab or label holding magazine. Some exemplary embodiments of the invention are suitable for securing protective covering to lumber product and may be configured for rectangular polyolefin tabs measuring approximately 0.035 inch thick and 1.0 inches by 2.0 inches.

Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

Abstract: The invention comprises a staple gun with highly compact accessory apparatus for attaching a planar tab or label to a fixing surface. The accessory has a housing and a positioning and indexing assembly associated with the housing which is operable to feed and hold a tab or label between the staple gun head and fixing surface, thereby allowing single-handed fixing of a label or tab to a fixing surface. The apparatus can include a roller assembly, staple gun and accessory apparatus or have all components integrated into the construction of a staple gun apparatus. Preferably, the apparatus is mated with a tab or label holding magazine. Some exemplary embodiments of the invention are suitable for securing protective covering to lumber product and may be configured for rectangular polyolefin tabs measuring approximately 0.035 inch thick and 1.0 inches by 2.0 inches.

Abstract: The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR9, where R9 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R10 and R11 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl alkynylaryl or R2 and R3 together form a cycloalkyl or a cycloaryl moiety; R4 is hydrogen or methyl; R5 is hydrogen, hydroxyl, oxo, or together with R6 and the carbons to which they are attached form a cyclic carbonate; R6 is hydrogen, hydroxyl, OR12 where R12 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate; R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkyn

Abstract: The invention comprises a staple gun with highly compact accessory apparatus for attaching a planar tab or label to a fixing surface. The accessory has a housing and a positioning and indexing assembly associated with the housing which is operable to feed and hold a tab or label between the staple gun head and fixing surface, thereby allowing single-handed fixing of a label or tab to a fixing surface. The apparatus can include a roller assembly, staple gun and accessory apparatus or have all components integrated into the construction of a staple gun apparatus. Preferably, the apparatus is mated with a tab or label holding magazine. Some exemplary embodiments of the invention are suitable for securing protective covering to lumber product and may be configured for rectangular polyolefin tabs measuring approximately 0.035 inch thick and 1.0 inches by 2.0 inches.

Abstract: The present invention provides novel macrolide compounds of the formulas 1

Abstract: Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

Abstract: Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

Abstract: The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR9,  where R9 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R10 and R11 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl, alkynylaryl or R2 and R3 together form a cycloalkyl or a cycloaryl moiety; R4 is hydrogen or methyl; R5 is hydrogen, hydroxyl, oxo, or together with R6 and the carbons to which they are attached form a cyclic carbonate; R6 is hydrogen, hydroxyl, OR12 where R12 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate; R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C1

Abstract: Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

Abstract: The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and methods and formulations for their use. In one aspect of the present invention, sixteen-membered macrolide possessing a side chain Z are provided where Z is aliphatic, aryl, alkylaryl, halide, ═NOR3, ═NNHR3, or —W—R3 where W is O, S, NC(═O)R4, NC(═O)OR4, NC(═O)NHR4 or NR4 where R3 and R4 are each independently hydrogen, aliphatic, aryl or alkylaryl. In another aspect of the present invention, bicyclic compounds are provided where one of the cyclic-components is a sixteen-membered macrolide and the other is a cyclic moiety whose cyclic structure is formed by between 3 and 10 atoms. In another aspect of the present invention, sixteen-membered macrolide compounds that bind to the domain II region of the 23S RNA are provided.