Patents by Inventor Mark Bushfield

Mark Bushfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200123537
    Abstract: A method of screening is provided. In certain embodiments, the method involves a) obtaining the nucleotide sequences of: i. a heavy chain-encoding nucleic acid that encodes the variable domain of a heavy chain of a first antibody of an animal; and ii. a light chain-encoding nucleic acid that encodes the variable domain of a light chain of the first antibody; b) obtaining nucleotide sequences of cDNAs encoding at least a portion of the antibody repertoire of the animal; c) computationally screening the sequences obtained in b) to identify heavy and light chain sequences that are related by lineage to the heavy and light chain sequences of a); and d) testing at least one pair of the heavy and light chain sequences identified in c) to identify a second antibody that binds to the same antigen as the first antibody.
    Type: Application
    Filed: September 25, 2019
    Publication date: April 23, 2020
    Inventors: Mark Bushfield, Michael HADJISAVAS, Luc ADAM
  • Patent number: 10465186
    Abstract: A method of screening is provided. In certain embodiments, the method involves a) obtaining the nucleotide sequences of: i. a heavy chain-encoding nucleic acid that encodes the variable domain of a heavy chain of a first antibody of an animal; and ii. a light chain-encoding nucleic acid that encodes the variable domain of a light chain of the first antibody; b) obtaining nucleotide sequences of cDNAs encoding at least a portion of the antibody repertoire of the animal; c) computationally screening the sequences obtained in b) to identify heavy and light chain sequences that are related by lineage to the heavy and light chain sequences of a); and d) testing at least one pair of the heavy and light chain sequences identified in c) to identify a second antibody that binds to the same antigen as the first antibody.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: November 5, 2019
    Assignee: EPITOMICS, INC.
    Inventors: Mark Bushfield, Michael Hadjisavas, Luc Adam
  • Publication number: 20160319275
    Abstract: A method of screening is provided. In certain embodiments, the method involves a) obtaining the nucleotide sequences of: i. a heavy chain-encoding nucleic acid that encodes the variable domain of a heavy chain of a first antibody of an animal; and ii. a light chain-encoding nucleic acid that encodes the variable domain of a light chain of the first antibody; b) obtaining nucleotide sequences of cDNAs encoding at least a portion of the antibody repertoire of the animal; c) computationally screening the sequences obtained in b) to identify heavy and light chain sequences that are related by lineage to the heavy and light chain sequences of a); and d) testing at least one pair of the heavy and light chain sequences identified in c) to identify a second antibody that binds to the same antigen as the first antibody.
    Type: Application
    Filed: August 13, 2014
    Publication date: November 3, 2016
    Applicant: Epitomics, Inc.
    Inventors: Mark BUSHFIELD, Michael HADJISAVAS, Luc ADAM
  • Patent number: 8022076
    Abstract: This invention relates to novel compound of formula (I) or pharmaceutically acceptable salts thereof. The invention is also directed to the uses of compounds having formula (I) in the treatment or prevention of diseases or disorders which requires potassium channel inhibition to an animal, mammal or human in need thereof. The invention is also directed to the use of compounds having formula (I) in the treatment or prevention of arrhythmia to an animal, mammal or human in need thereof.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: September 20, 2011
    Assignee: Xention Limited
    Inventors: John Ford, Nicholas John Palmer, John Frederick Atherall, David John Madge, Brad Sherborne, Mark Bushfield, Edward Benedict Stevens
  • Publication number: 20050026935
    Abstract: This invention relates to novel compound of formula (I) or pharmaceutically acceptable salts thereof. The invention is also directed to the uses of compounds having formula (I) in the treatment or prevention of diseases or disorders which requires potassium channel inhibition to an animal, mammal or human in need thereof. The invention is also directed to the use of compounds having formula (I) in the treatment or prevention of arrhythmia to an animal, mammal or human in need thereof.
    Type: Application
    Filed: June 10, 2004
    Publication date: February 3, 2005
    Inventors: John Ford, Nicholas Palmer, John Atherall, David Madge, Brad Sherborne, Mark Bushfield, Edward Stevens