Patents by Inventor Mark C. Connelly

Mark C. Connelly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190107542
    Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
    Type: Application
    Filed: November 30, 2018
    Publication date: April 11, 2019
    Inventors: Galla Chandra Rao, Mark C. Connelly, Mariano A. Garcia-Blanco, Andrew J. Armstrong, Rhonda L. Bitting
  • Patent number: 10161939
    Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: December 25, 2018
    Assignees: Duke University, Janssen Diagnostics, LLC
    Inventors: Galla Chandra Rao, Mark C. Connelly, Mariano A. Garcia-Blanco, Andrew J. Armstrong, Rhonda L. Bitting
  • Publication number: 20180231560
    Abstract: This disclosure provides compositions and methods for the isolation of cells that express c-MET, and in particular circulating tumor cells that express c-MET. The methods can include contacting a biological sample including a c-MET circulating tumor cell with an unbound complex including a capture binding species linked to a solid phase for a time sufficient to allow the unbound complex to bind an extracellular binding domain of the c-MET protein to form a bound complex, and subsequently isolating the bound complex. Compositions, systems, and kits adapted for use with these methods are also provided.
    Type: Application
    Filed: September 15, 2015
    Publication date: August 16, 2018
    Inventors: Galla Chandra Rao, Mark C. Connelly, Rengasamy BOOMINATHAN, Tian Zhang, Mariano A. Garcia-Blanco, Andrew J. Armstrong
  • Publication number: 20160077097
    Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
    Type: Application
    Filed: May 31, 2013
    Publication date: March 17, 2016
    Inventors: Galla Chandra Rao, Mark C. Connelly, Mariano A. Garcia-Blanco, Andrew J. Armstrong, Rhonda L. Bitting
  • Publication number: 20110300551
    Abstract: The present invention provides an automated method for capturing and detecting circulating melanoma cells (CMC's) in the blood of patients with melanoma. The absolute number of circulating melanoma cells detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy.
    Type: Application
    Filed: June 8, 2011
    Publication date: December 8, 2011
    Inventors: Galla Chandra Rao, Mark C. Connelly
  • Patent number: 5597688
    Abstract: The present invention provides a novel cellular fixative composition and method of cellular fixing and cellular analysis wherein cells may be fixed for further analysis without destroying the cell's surface markers, cellular morphology, and the cell's light scattering properties. Treatment of cells with the fixative as described herein also allows antibodies or .other desired components to enter the cell through the cellular membrane, without allowing important contents of the cell to escape. As an added benefit, the fixative composition of the invention may also kill or at least inactivate or reduce the activity of deadly virus contained in the cell. In its broadest aspect, the presently claimed fixative composition comprises at least three components, and in more preferred embodiments, four components.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 28, 1997
    Assignee: Ortho Diagnostic Systems Inc.
    Inventors: Mark C. Connelly, Utpal R. Chakraborty, Houston G. Brooks, Jr.
  • Patent number: 5422277
    Abstract: A cell fixative composition for fixing the internal components of a cell without disrupting the cell surface components is disclosed. The composition contains a compound for preserving intracellular morphology, a compound for fixing internal components of the cell, a compound which facilitates transportation of components across the cellular membrane, and a compound for increasing permeability of cell membranes. Methods for analyzing cells which have been fixed using the composition are also disclosed.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: June 6, 1995
    Assignee: Ortho Diagnostic Systems Inc.
    Inventors: Mark C. Connelly, Utpal R. Chakraborty, Houston G. Brooks, Jr.
  • Patent number: 4906567
    Abstract: Sandwich assays for detecting and identifying lipopolysaccharides of gram negative bacteria utilizing immobilized lipopolysaccharide binding proteins and labelled detection reagents are provided. The active supports are also useful in removing LPS from biomedical and cosmetic preparations.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: March 6, 1990
    Assignee: E. I. Dupont De Nemours and Company
    Inventor: Mark C. Connelly